The peptide-based approach
In-silico design of an Epitope-based peptide vaccine: A Computational Biology Approach
... epitope-based peptide vaccine against Lymphocytic choriomeningitis virus using a computational biology ...The peptide sequence VVQNLDQLY, a non-allergen, was found to be a potent T-cell epitope that ...
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The P42 peptide and Peptide-based therapies for Huntington’s disease
... Finally, several intracellular antibodies, known as intrabodies, binding to different part of the N-terminal Htt have also been identified to date. The intrabodies identified so far recognize a region in Htt other than ...
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Hierarchically imprinted polymer for peptide tag recognition based on an oriented surface epitope approach
... We performed extensive, 1 µs MD simulation for each system using the FF14SB all– atom Amber force field 5,11 and the TIP3P water 12 or the DMSO models in all calculations. The DMSO solvent box, created by John Dalmaris ...
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Predicting class II MHC-Peptide binding:a kernel based approach using similarity scores
... in peptide evaluation, quantifying the overall sim- ilarity between peptides and interrelations between resi- ...a peptide string. Instead, higher order interactions within the peptide may also make ...
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An Integrated In-Silico Approach to Develop Epitope-Based Peptide Vaccine against SARS-CoV-2
... This approach is highly validated for the designing and development of potent ...identify peptide fragments from spike surface glycoprotein that can be efficiently used for the designing and development of ...
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Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
... novel approach integrating immunogenetics and immunogenomics with bioinformatics for the development of vaccines is known as ...This approach has been used to address the development of new ...conventional ...
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Peptide-based materials for cancer immunotherapy
... collagen-mimetic peptide (GFO-GER) to deliver CAR T cells to the tumor ...core peptide, Pam2Cys and Pam3Cys) were conjugated to an engineered polytope that could self-assemble into nanoparticles and they ...
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Inhibition of Ral GTPases Using a Stapled Peptide Approach
... in the cellular environment (5,6). Logical attempts to interfere with critical post-translational modifications of Ras, such as inhibition of farnesyltransferase, have also proved unsuccessful (reviewed in (1,6,7)). More ...
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Applications of peptide and protein-based materials in bionanotechnology
... novo peptide sequences that could catalyze the synthesis of materials of technological relevance via molecular biology tools such as phage ...this approach, DNA fragments encoding random peptide ...
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Coarse-Grained Peptide Modeling Using a Systematic Multiscale Approach
... emphasis of this study is more to reproduce equilibrium structural properties than to describe time-dependent phe- nomena. Consequently, we focus on average quantities in the discussions that follow. The reference ...
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CAEPIDR: A COMPUTATIONAL APPROACH TO EFFICIENT PEPTIDE INFLUENCED DRUG REPURPOSING
... such approach, molecular docking techniques are used to assess the binding affinity of a subset of a compound ...this approach, Plewczynski was able to find 60% of the active compounds for a protein target ...
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Peptide-based functional annotation of carbohydrate-active enzymes by conserved unique peptide patterns (CUPP)
... an approach, however, is likely to introduce a bias that causes the first group to be inherently larger and thus reduce reproducibility and ...clustering approach, which is presented here and in the recent ...
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A lipidic α-amino acid based adjuvant/carrier system for peptide delivery and enhancing peptide immunogenicity
... for peptide delivery Enhancement of membrane transport and cellular uptake of drugs can be divided into two broad categories, physical methods and chemical ...particular approach may result in a ...
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Peptide-based subunit vaccine against hookworm infection
... B-cell peptide epitope was chosen from the apical enzyme in the hemoglobin digestion cascade, the aspartic protease ...Core Peptide (LCP) self-adjuvanting ...chimeric peptide induced a strong IgG ...
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Developing Peptide Based Capture Agents for Diagnostics and Therapeutics
... engineering approach using an alternative small and robust protein scaffold with favorable folding and stability, and easy bacterial ...is based on Z domain of protein A and DARPins that use ankyrin repeat ...
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Evaluating Peptide Mass Fingerprinting-based Protein Identification
... used approach is to use PMF as an initial step, and then use MS/MS to corroborate proteins that are considered ...probability based and there always remains a chance of obtaining a false positive protein ...
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Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach
... motif based on binding of HLA-E to random peptide library Having validated that the extent of HLA-E refolding could be assessed after in vitro refolding, we went on to test the nonamer random peptide ...
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The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling
... knowledge-based approach, we constructed a 3D model of agonist-bound GLP-1R, basing the conformation of the N-terminal region on that of the receptor-bound NMR structure of the related peptide ...
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Miniaturized biosensors and microdevices based on peptide for food industry and healthcare
... the peptide within polymeric network improves both the affinity and the specificity of protein ...a peptide-based biosensor for autofluorescence aflatoxin M1 detection in a sensitive, specific and ...
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Computational approaches to understanding the self-assembly of peptide-based nanostructures
... AAFF approach is able to provide detailed structural and energetic data for nanostructured ...AAFF approach. The self- assembly of typical peptide-based systems occur over the µs – ms time ...
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