The PI3K-Akt pathway
The PI3K/Akt Pathway Contributes to Arenavirus Budding
... the PI3K/Akt pathway could reduce the virus load and rate of propagation and thereby provide the host with a window of opportunity to mount an efficient antiviral immune ...or pathway required ...
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The PI3K/AKT pathway in obesity and type 2 diabetes
... the PI3K/AKT signalling pathway is required for normal metabolism due to its characteristics, and its imbalance leads to the development of obesity and type 2 diabetes ...of PI3K/AKT ...
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COL6A3 promotes cellular malignancy of osteosarcoma by activating the PI3K/AKT pathway
... the PI3K/AKT signaling pathway in ...the PI3K/AKT signaling pathway was manipulated by measuring the protein expression of the PI3K/AKT pathway-related ...
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Control of the PI3K/Akt pathway by porcine reproductive and respiratory syndrome virus
... transduction pathway in the regulation of cell sur- vival, cell proliferation and differentiation, and cell apoptosis [ 6 – 8 , 10 ...of PI3K-Akt pathway promotes cell survival by the ...
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Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway
... that AKT was constitutively active in the majority ...the PI3K/AKT pathway with specific inhibitors, wortmannin and LY294002, significantly reduced Bcl-xL expression, induced ...
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Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway
... Indeed, in many types of cancer cells, insulin induces resistance to chemotherapeutic drugs and may contribute to poor prognosis, particularly in patients with obesity and type II diabetes. 32,33 However, the role of ...
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Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression
... the PI3K/Akt pathway in a protein tyrosine phosphatase 1B (PTP1B)-dependent ...enhances PI3K-dependent basal and growth factor-induced Akt ...enhanced Akt activation in response ...
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RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma
... the PI3K pathway in melanocytes and its frequent over-activation in ...the PI3K pathway in melanocytic ...selective PI3K or mTOR inhibitors than to dual PI3K/mTOR ...to ...
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Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
... the PI3K/ AKT /GSK-3 β pathway Several medicinal herbs and foods may regulate the activity of the PI3K/ AKT /GSK-3β ...the PI3K/ AKT /GSK-3β pathway ...the ...
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Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway
... China has a long history of using natural products as ergogenic aids to enhance athletic performance. The dried root of Angelica Sinensis (AS) is widely used in traditional Chinese medicine to “nourish one’s vitality and ...
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Acetylshikonin Inhibits Colorectal Cancer Growth via PI3K/Akt/mTOR Signaling Pathway
... the PI3K/Akt pathway using LY294002 enhanced the anti-cancer effect of ...through PI3K/Akt/mTOR ...inhibiting PI3K/Akt/mTOR ...
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MYO18B promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR signaling pathway
... the PI3K/ AKT/mTOR signaling pathway. PI3K/AKT/mTOR sig- naling pathway is a major activated signaling pathway in human malignancies, and regulates multiple cellular pro- ...
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JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer
... regulates AKT activity. Loss of PTEN and activation of the PI3K/ AKT pathway results in resistance to targeted therapies with small molecule compounds in some cancers including endometrial ...
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CAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway
... signaling pathway retards RCC progression. 32 The PI3K/ AKT pathway is highly activated in RCC ...This pathway is a promising drug ...EGFR, PI3K and p-AKT in vitro and in ...
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ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas
... (PI3K)/AKT pathway, such as mutations in PIK3CA encoding the catalytic subunit, p110�, of ...the PI3K/AKT pathway in endometriosis and endometriosis-associated ovarian ...
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Development of Dual-Pathway Inhibitors of Raf/MEK/ERK and PI3K/Akt Signaling Pathways.
... the PI3K/Akt pathway, mutations are most frequently reported at Akt, PTEN and ...the PI3K/PTEN/Akt pathway, the main therapeutic targets: PI3K, mTOR and Akt ...
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PI3K/AKT pathway in modulating glucose homeostasis
... Overexpression of SHIP2 which is a negative regulator of insulin signal transduction, reduces the production of insu- lin-dependent PIP3, insulin-induced AKT activation, as well as GSK3 inactivation/GS activation ...
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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
... the PI3K pathway plays a central role in various cellular processes that can contribute to the malignant ...of PI3K, Akt, and mTORC1 and 2 are now passing through early phase clinical ...
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Necessity to evaluate PI3K/Akt signalling pathway in proarrhythmia
... Clinical practice, clinical pharmacology, cardiac electro- physiology and genetics have raised awareness of inci- dence of QT prolongation and TdP. Biotechnology and pharmaceutical companies screen compounds for kv11.1 ...
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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
... on PI3K sIGnAlInG PAthwAy Though more and more PI3K/Akt/mTOR targeted drugs emerge, they are still undergoing preclinical or clinical ...on PI3K signal ...
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