The Stem Cell Niche
Dormancy in the stem cell niche
... of stem cell proliferation; overall, however, stem cells are quiescent if compared with their direct ...hematopoietic stem cells (HSCs) raises a number of fundamental questions. As stem ...
6
Enabling stem cell therapies through synthetic stem cell–niche engineering
... regulate stem cell–niche parame- ters have reached the proof-of-principle stage, where a particular technique is shown to regulate stem cell behavior without deep mechanistic insight ...
12
The spermatogonial stem cell niche in testicular germ cell tumors
... of Stem Cells, Development and Cancer, Department of Cell Biology and Histology and 2 Analytical and High Resolution Biomedical Microscopy Core Facility, University of the Basque Country, Vizcaya, Spain ...
12
The stem cell niche: tissue physiology at a single cell level
... high cell turnover. Stem cell regulation accommodates the conflicting needs of prompt responsiveness to injury and long-term preservation through quies- ...the stem cell niche in ...
7
Adhesion in the stem cell niche: biological roles and regulation
... in stem cells The molecules involved in stem cell-niche adhesion have been identified and characterized using a variety of ...in stem cell-niche physical interaction has ...
11
The stem cell niche finds its true north
... the niche The warm pre-summer Danish weather and a beautiful setting at Favrholm campus provided a stimulating ‘ niche ’ for meeting ...the niche where stem cells reside has a profound ...
5
The hematopoietic stem cell niche: from embryo to adult
... The stem cell ‘ niche ’ , as proposed by Schofield (1978), provides a specialized microenvironment that preserves their repopulating capacity (Glossary, Box ...this niche, with recent evidence ...
12
The hematopoietic stem cell niche. Share Your Story
... tissue stem or progenitor cells. In general, tissue stem cells make up a very small percentage of the total population and lack the functionality of their fully-differentiated ...tissue stem cells ...
Signaling in the stem cell niche: regulating cell fate, function and plasticity
... the stem cell niche, allowing plasticity and adaptability to changing conditions (Chacón-Martínez et ...the niche, which influence stem cell state and fate (Morrison and ...
11
Lmx1a is required for the development of the ovarian stem cell niche in Drosophila
... adult stem cell ...as cell type-specific and stage-specific knockdown of Lmx1a, we have determined that Lmx1a is required for ovary development specifically in the TF-cap cell niche at ...
14
Novel Regulators in the Germline Stem Cell Niche of Drosophila Testis
... DiNardo Stem cells are powerful and promising tools in regenerative ...how stem cells are maintained in vivo is crucial for their clinical ...various stem cell systems have demonstrated that ...
138
The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche
... including stem cells. They form an important component of the stem cell ...many cell types; however, they are most abundant in the cells and tissues of mesodermal ...
14
The Role of FoxJ1 in the Development and Regulation of the Adult Neural Stem Cell Niche
... adult stem cell niche Stem cells are found throughout the embryonic ...most stem cells differentiate into their final target tissue but some retain various levels of multipotency into ...
130
Dissecting the stem cell niche with organoid models: an engineering based approach
... the stem cell niche by providing powerful means of interrogating organoids at the single cell level, as well as a means to guide the morphogenesis of organoids with significantly greater ...in ...
10
Localisation of corneal epithelial progenitors and characterization of cell-cell interactions in the human limbal stem cell niche
... limbal stem cell niche in which limbal fibroblasts were co-cultured with limbal epithelial cells in a serum free culture ...maintained stem cell characteristics with the ability to ...
237
New insights into male gametogenesis: what about the spermatogonial stem cell niche?
... spermatogonial stem cells (SSCs) are at the foundation of ...the stem cells and extrinsic signals, including soluble factors and adhesion molecules from the surrounding microenvironment, known as the SSC ...
7
Mesenchymal Cell Contributions to the Stem Cell Niche
... these cell populations in skeletal develop- ment and repair and in the regulation of hematopoietic ...the cell types and how they interact with each other, with neighboring cells of endothelial or neural ...
15
The stem cell niche, formed by surrounding stromal
... GSC niche and suggest a possible common origin for these two stem cell ...niches. Cell-autonomous JAK/STAT activity is required in male GSC for self-renewal, but dispensable for female GSC ...
8
The stem cell niche: lessons from the Drosophila testis
... hub cell specification was thought to occur late in ...hub cell fate (Okegbe and DiNardo, ...hub cell formation, is activated in posterior SGPs and restricts hub cell formation to the anterior ...
9
Hemmule: A Novel Structure with the Properties of the Stem Cell Niche
... large size cells, cells inside bone marrow vessels, cells around footprints, and are scattered around. 442.[r] ...
36