The Tasmanian Devil and DFTD
Transcriptome and proteome profiling reveals stress induced expression signatures of imiquimod treated Tasmanian devil facial tumor disease (DFTD) cells
... from devil facial tumor disease (DFTD), a transmissible cancer threatening the survival of the Tasmanian devil (Sarcophilus harrisii), are sensitive to imiquimod-induced ...in DFTD have ...
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Population and disease modelling in the Tasmanian devil
... previous work (Roberts and Jowett 1996), this chapter looks at the particular model in more detail, analysing it in terms of the Tasmanian devil and DFTD. I then extend on this model framework in ...
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Immune recognition of devil facial tumour disease by the Tasmanian devil
... “wild devil recovery” project. The use of DFTD cells expressing MHC-I as the antigenic basis for the immunisation trial described in Chapter 6 resulted in antibody responses against both MHC-I +ve and MHC-I ...
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To what extent do we understand DFTD, and what are the conservation options for Tasmanian Devils?
... Tasmanian devil conservation Having collated extensive information on the transmissible nature and malignant pathology of DFTD tumours, it is clear that Tasmanian devils are in a very ...
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Toll like receptors in the endangered Tasmanian devil and devil facial tumour disease
... In comparison to the NNP immunisation trial, SH devils exhibited more rapid responses to immunisation, as demonstrated by the increase in specific-IgG levels at day 28. A small number of individuals in the NNP cohort ...
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The devil is in the details: Genomics of transmissible cancers in Tasmanian devils
... Tasmanian devil facial tumor disease: Genomics of susceptibility For an allograft to avoid rejection from a new host, it must circumvent recognition by major histocompatibility complex (MHC) genes ...of ...
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Spatial analysis of Tasmanian Devil facial tumour disease
... of DFTD is dependent on devil population density (Jones M, pers ...with devil habitat and perform spatial analysis to map areas of devil habitat suitability which can be used to determine ...
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The ERBB STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
... marsupial Tasmanian devil ( Sarcophilus harrisii ) faces extinction due to transmissible devil facial tumor disease ...save Tasmanian devils from ...
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An investigation into factors affecting breeding success in the Tasmanian devil (Sarcophilus harrisii)
... As DFTD is not vertically transmitted, additional founders are still available for incorporating into the insurance population which is continuing to feed into the founder base of this ...
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Tasman PCR: A genetic diagnostic assay for Tasmanian devil facial tumour diseases
... Overall, this study presents Tasman-PCR, a PCR-based assay for rapid, high-throughput diagnosis of DFT1 and DFT2 in Tasmanian devils. By screening 546 tumours, we have documented the distributions of DFT1 and ...
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Biomarker discovery for pre clinical diagnosis of Tasmanian devil facial tumour disease
... by Tasmanian devils when they feed on carcases and other meat since they consume the whole carcass including the skeleton ...When DFTD becomes advanced, the position of the tumours could make it difficult ...
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Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
... devastating Tasmanian devil facial tumour ...the Tasmanian devil is able to mount specific humoral and cellular responses to facilitate the eradication of established ...tumours. DFTD ...
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Manipulating the immune response of Tasmanian Devils to target Devil Facial Tumour Disease
... in DFTD cells ...against DFTD and alter the antigen expression of the tumour cells, provide two potential directions for immunotherapy: adoptive cell transfer or therapeutic ...a Tasmanian ...
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Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease
... normal Tasmanian devil tissue, primary DFTD tumours and DFTD cell ...in DFTD cells in vitro, by exposing the cells to environmental stressors such as heat shock and ...
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Untangling the model muddle: Empirical tumour growth in Tasmanian devil facial tumour disease
... Tasmanian devil facial tumour disease (DFTD) is a rare transmissible cancer threatening its unique host, the Tasmanian devil (Sarcophilus harrisii) 16, 17 ...ago, DFTD has ...
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The diet of the Tasmanian Devil, Sarcophilus harrisii, as determined from analysis of scat and stomach contents
... of Tasmanian Devils, Sarcophilus harrisii, is limited and based upon largely qualitative ...of Tasmanian Devils at six sites by identifying undigested hair, bone and feathers found in their ...encompass ...
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Immunization strategies producing a humoral IgG immune response against devil facial tumor disease in the majority of Tasmanian devils destined for wild release
... individual devil may influence its response to DFTD ...against DFTD is more likely if the MHC of the devil and the tumor are ...affects devil responses to naturally occurring ...
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The Tasmanian devil microbiome—implications for conservation and management
... adult devil (>2 years) on aver- age measures around 60 cm long with a 25-cm tail and 30 cm high at the shoulder ...female devil has only four teats in her pouch ...
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Social organisation and behaviour of the Tasmanian devil, Sarcophilus harrisii
... Interaction between the members of this population is intense and manifests itself in the lower reproductive potential of those females who are not continuous residents and the latent [r] ...
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Social organisation and behaviour of the Tasmanian devil, Sarcophilus harrisii
... The open squares are the cells in which the animals were located by triangulation and the numbers in the cell frequency with which animals were located in the cell if they were caught [r] ...
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