the tumor microenvironment
A Review of Exosomes and their Role in The Tumor Microenvironment and Host-Tumor "Macroenvironment"
... the tumor microenvironment (TME) and the hypothesis that exosomes may also generate a host-tumor “macroenvironment” beyond the TME through their miRNA and protein payloads, so to speak “fertilizing ...
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Optimization of the tumor microenvironment and nanomedicine properties simultaneously to improve tumor therapy
... of tumor cells into the vascular system [42], which was considered as a prerequisite for tumor ...metastasis. Tumor matrix disruption could also reduce the occurrence of tumor metastasis by ...
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Tumor associated stromal cells as key contributors to the tumor microenvironment
... in tumor progression, it is highly probable that any TASC population is a heterogeneous mixture of not only reactive stroma ...the tumor microenvironment during excision? Moreover, it is possible ...
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Osteopontin controls immunosuppression in the tumor microenvironment
... the tumor microenvironment, and suppresses T cell proliferation and IFN-γ secretion by binding to CD44, which is highly expressed on activated T ...a tumor suppressor, as it represses OPN (encoded by ...
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Breast cancer stem cells, cytokine networks, and the tumor microenvironment
... the tumor microenvironment — including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells — through networks of cytokines and growth ...
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A review of the development of tumor vasculature and its effects on the tumor microenvironment
... drives tumor angiogenesis and causes the vasculature to develop much differently in tumors than in normal ...the tumor vasculature for the treatment of solid ...the tumor vascu- lature that are ...
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Effect of Cyclosporin a on the Tumor Microenvironment
... several tumor types in a cell autonomous ...multiform tumor cell survival by stabilizing the oncogenic proteins myc and p53, likely through its chaperone activity (Choi et ...
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Role of the complement system in the tumor microenvironment
... glial tumor, suggesting that low levels of MBL might protect against the initiation and progres- sion of glioblastoma multiforme [112]; furthermore, high serum levels of mannan-binding lectin-associated serine ...
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Low pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response
... or tumor tissues ...profound tumor suppression effect within 4 days caused by MB-presented FUS exposure ...into tumor tissues, thereby providing direct evidence of an increase in tumor ...
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Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
... immune microenvironment is closely related to tumor initiation, prognosis, and response to ...the tumor vary in across different types of ...the tumor, can yield information relevant to the ...
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6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression
... the tumor microenvironment and decreased MSE in ...and tumor volume are ...local tumor tissue and improved the microenvironment surrounding ...
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Expanding role of lenalidomide in hematologic malignancies
... Lenalidomide is an IMiD that has effects on tumor cells and the tumor microenvironment leading to clinical efficacy across a diverse spectrum of hematologic malignancies. Recent insights into the ...
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Interaction of tumor cells with the microenvironment
... in tumor tis- sues often correlates with poor prognosis for cancer patients ...on tumor growth and metasta- sis development reflect different states of activation acquired by TAMs in the tumor ...
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The lymphatic vasculature revisited
... of tumor cell invasion into lymphatic vessels and colonization of the lymph nodes, current knowledge relies primarily on correlative ...the tumor microenvironment (32), the biochem- istry of ...
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Myeloid cell signatures in tumor microenvironment predicts therapeutic response in cancer
... the tumor vasculature develop- ment under hypoxic ...of tumor-promoting VEGF, basic fibroblast growth factor, IL-8 chemokines, and lymphangiogenic ...Surprisingly, tumor cell-derived Sema3A, not ...
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Conflicting Roles of Connexin43 in Tumor-Induced Inflammation and Cancer Pathology
... Reactive Astrocytes, Immune Cells, and Cx43 Expression in the Glioma Microenvironment 23.. The interaction between tumor cells and their microenvironment is implicated in modulating [r] ...
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TAM receptors, Phosphatidylserine, inflammation, and Cancer
... MERTK-dependent tumor- suppressive ...supporting tumor growth ...of tumor - infiltrating lymphocytes and killing of autologous melan- oma cells ...in tumor cells which highly express the TAM ...
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Analysis of PD-1 related immune transcriptional profile in different cancer types
... and have been approved by the U.S. Food and Drug Administration (FDA) for human use [3]. Antibodies targeting PD-1 have demonstrated clinical benefits in multiple cancer types, such as advanced melanoma, non- small-cell ...
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Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer
... transformed tumor associated-endothelium can prove to be an alternate approach that is currently ...murine tumor model. We demonstrate inhibition of tumor growth and metastasis in response to the ...
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The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
... Ras-related tumor suppressor gene aplasia Ras homolog member I (ARHI; also known as DIRAS3) is downregulated in more than 60% of ovarian cancers, and here we show that re-expression of ARHI in multiple human ...
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