the type IV secretion system
Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase
... VirB type IV secretion system (T4SS), a protein translocation apparatus essential for intracellular replication, modulation of host immune functions, and establishment of chronic brucellosis ...
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Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes
... Cag type IV secretion system (TFSS) translocates the virulence factor cytotoxin-associated gene A protein into host cells and plays an important role in initiating gastric ...
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Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress Mediated Cell Death and Fetal Loss via Type IV Secretion System Dependent Activation of CHOP
... phagocyte system, where it elicits low-level granulomatous inflammation ...VirB type IV secretion system (T4SS), can replicate in the placenta without causing abortion (9, ...
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Membrane and Core Periplasmic Agrobacterium tumefaciens Virulence Type IV Secretion System Components Localize to Multiple Sites around the Bacterial Perimeter during Lateral Attachment to Plant Cells
... IMPORTANCE Transfer of DNA and/or proteins to host cells through multiprotein type IV secretion system (T4SS) complexes that span the bacterial cell envelope is critical to bacterial ...
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Translocation through the Conjugative Type IV Secretion System requires unfolding of its protein substrate
... Relaxase constructs that block substrate translocation in the native plasmid. The experiments described above were conducted using an artificial two-plasmid system reporting on protein transport to the recipient ...
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In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
... sequentially, by elaboration first of the Cag cylinder and then the outer spoked wheel. In step I, the three “core” subunits CagX, CagY, and CagM assemble as the Cag cylinder, a substructure sufficiently stable for ...
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Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex
... Purification of CagF and copurification of additional Cag pro- teins. Previous studies have shown that the H. pylori cagA effector protein interacts with another cag PAI-encoded protein, CagF (31–33). CagF is required ...
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Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens
... inhibit secretion of IL-8 and activa- tion of NF-B signaling in ...of type 1 pili or curli in ...IL-8 secretion and NF-B ac- tivation (C10 and KSK85 [Table 1]) in a dose-dependent manner ...IL-8 ...
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Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
... genome shows genetic diversity among distinct isolates, and H. pylori pathogenicity is different in distinct iso- lates. Bacterial virulence factors exert an important influence in determining the clinical outcomes, and ...
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Zhao, Qing (2017): Integrin-independent Helicobacter pylori CagA translocation via type IV secretion. Dissertation, LMU München: Medizinische Fakultät
... the type IV secretion system (T4SS) is considered as a major risk factor for gastric diseases including gastric ...a type IV secretion system component protein ...
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Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori
... HtrA secretion, cleavage of E-cadherin, bacterial transmigration and delivery of the type IV secretion system (T4SS) effector protein CagA into polarized epithelial cells, but did not ...
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Molecular detection of Bartonella henselae in 11 Ixodes ricinus ticks extracted from a single cat
... Bartonella adhesin A (BadA) mediates adhesion of Bartonella spp. to endothelial cells and the extracellular matrix proteins [24]. The VirB/VirD4 type IV secretion system (VirB) translocates ...
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Identification of a Novel Conjugative Plasmid in Mycobacteria That Requires Both Type IV and Type VII Secretion
... the type IV secretion ...novel type of conjugative plasmid that seems to be unique for ...three type IV secretion system components and a ...new type VII ...
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Type IV secretion in Gram negative and Gram positive bacteria
... of CCVs is reflected by the accumulation of late endosomal markers LAMP-1/-2, vasodilator-stimulated phosphoprotein (VASP), as well as the V-ATPase (Voth and Heinzen, 2007; Colonne et al., 2016). Genome- wide gene ...
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Type IV secretion systems: versatility and diversity in function
... first type, found in many Gram-positive and Gram-negative bacteria and some archaea, is used for transferring DNA from one cell to the other in a cell-to-cell contact-dependent ...well-characterized system ...
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Structure of a bacterial type IV secretion core complex at subnanometre resolution
... Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of ...T4S system mechanisms can be ...
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Structural organisation of the type IV secretion systems
... VirB11 and VirD4) and the VirB3, VirB6 and parts of the VirB8 and VirB10 proteins. The ATPases power system assembly and substrate translocation [17–21]. VirB3, VirB6, and VirB8 are likely to anchor VirB4 (and ...
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Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response
... immune system to differentiate be- tween friend and foe ...include type III and IV secretion systems (T3SS and T4SS, respectively) that translocate bacterial PAMPs such as flagellin, ...
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Recent advances in the structural and molecular biology of type IV secretion systems
... defined symmetry (14-fold for the core/OM complex, six- fold symmetry for each IMC barrel, and two-fold sym- metry between the two IMC barrels), the stalk does not exhibit any evident symmetry. It is an elongated struc- ...
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Secretome Analysis of Vibrio cholerae Type VI Secretion System Reveals a New Effector Immunity Pair
... removed, and supernatant was filtered through 0.22- m-pore-size filters. Protease inhibitors were added to filtrates to inhibit protein degradation. OMVs were removed by ultracentrifugation (130,000 ⫻ g for 4 h at 4°C) ...
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