Therapeutic implications
PI3K mutations in breast cancer: prognostic and therapeutic implications
... Abstract: The PI3K pathway is the most frequently enhanced oncogenic pathway in breast can- cer. Among mechanisms of PI3K enhancement, PIK3CA mutations are most frequently (∼30%) observed, along with protein loss of ...
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Hürthle cell carcinoma: diagnostic and therapeutic implications
... BioMed Central World Journal of Surgical Oncology ss Open AcceReview H?rthle cell carcinoma diagnostic and therapeutic implications Mohamed R Hanief*1, Laszlo Igali2 and Dimitrie Grama3 Address 1Imper[.] ...
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Enzyme Mediated Inflammation: Epidemiology and Therapeutic implications
... Enzyme Mediated Inflammation: Epidemiology and Therapeutic implications Parteek Prasher* Assistant Professor of Chemistry, University of Petroleum and Energy Study, Energy acres, Uttrakh[r] ...
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Echocardiographic evaluation of left ventricular strain in severe aortic stenosis with therapeutic implications and risk stratification
... Key words: aortic stenosis, speckle tracking echocardiography, strain Echocardiographic evaluation of left ventricular strain in severe aortic stenosis with therapeutic implications [r] ...
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Translational enhancers of EAAT2: therapeutic implications for neurodegenerative disease
... The comprehensive study by Kong et al. on the potential for a pyridazine-based compound to increase EAAT2 translation and provide therapeutic efficacy in rodent models of neurodegenerative disease has compelling ...
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Role of Cholinergic Receptors in Colorectal Cancer: Potential Therapeutic Implications of Vagus Nerve Stimulation?
... the therapeutic potential of VNS in CAC, not only by regulating inflammatory response at the immune level but also by preventing or limiting in- testinal barrier breakdown associated to the inflammation ...
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Somatostatin: Diverse Physiological Roles and Therapeutic Implications
... 21 Sim- ilarly, if glucagon is "removed" with somatostatin, there is a transient reduction in hepatic glucose out- put.22 Therefore, during chronic somatostatin [r] ...
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Statins and Sepsis: Possible Connections and Therapeutic Implications
... of therapeutic approach has been employed to modulate immunological response and the delicate balance between pro- inflammatory and anti-inflammatory responses in ...
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Synovitis in osteoarthritis: current understanding with therapeutic implications
... support therapeutic targeting of inflammation in OA is that the two pharmacological therapies with consistently good effect sizes in relieving OA pain are NSAIDs and IA corticosteroid injections [53]; both have ...
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Swallowed foreign bodies in children: diagnostic and therapeutic implications
... Summary of patients with swallowed FBs that required intervention FB Large coins Golden ring Piece of sharp blade Large button battery Piece of lamb bone Large plant seed Plastic sharp b[r] ...
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The biology and role of CD44 in cancer progression: therapeutic implications
... Roche has developed a novel functional mAb (RO5429083) which targets a glycosylated, conformation- dependent epitope of CD44. Based on preclinical investi- gations, RO5429083 and its radioimmunoconjugates were approved ...
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Microbiota and LPS-Induced Obesity Inflammation: Therapeutic Implications
... Recently the presence of LPS in the plasma has been linked to obesity-associated metabolic disorders, increasing the scientific interest for this molecule. LPS originates primarily from the gut microbiota. In the host, ...
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Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications
... flow carries the potential to exacerbate lethal tissue injury, a process termed as “ischemia/reperfusion injury”. The major contributory factors of reperfusion injury include oxidative stress[34], calcium overload [41], ...
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Multiple roles and therapeutic implications of Akt signaling in cancer
... 4EBP-1, 4E-binding protein 1; AGC, protein kinase A/protein kinase G/protein kinase C-like; Bcl-2, B-cell lymphoma 2; CAP, catabolite activator protein; CTMP, carboxyl-terminal [r] ...
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Alexithymia in eating disorders: therapeutic implications
... Despite the clinical relevance of alexithymia for ED, studies focusing on its therapeutical implications are still limited, being characterized by heterogeneous designs and significant methodological limitations. ...
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Therapeutic implications of osteoprotegerin
... innovative therapeutic strategies of OPG in metastatic breast and prostate carcinoma, multiple myeloma, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis and rheumatoid ...
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Peptides as epigenetic modulators: therapeutic implications
... Several approved peptide drugs are already being repo- sitioned to other indications. For example, lisinopril, a synthetic tripeptide derivative approved for treatment of hypertension and heart failure, binds strongly to ...
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PRACTICAL THERAPEUTIC IMPLICATIONS OF IMMATURITY
... with the administration of this drug to pre- mature infants.7’8 In these instances chioramphenicol was administered in even higher doses than usually recommended. for the adult, resultin[r] ...
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Diagnostic and Therapeutic Implications of Cholelithiasis in Children
... Introduction: Cholecystitis, for a long time considered as a disease of adults, has had an increased documented incidence of non-haemolitic cholelithiasis in the Pediatric Surgery practice in the last 20 years. Even ...
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Therapeutic implications of autoantibodies in rheumatoid arthritis
... There is a strong scienti fi c basis to support the contribu- tions of RF to the in fl ammatory disease process. First, RF has been shown, by complexing ACPA, to induce proin fl ammatory cytokines like tumour necrosis ...
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