Therapeutic strategy
Cellulose degradation: a therapeutic strategy in the improved treatment of Acanthamoeba infections
... potential therapeutic strategy in effective targeting of trophozoite encased within the cyst ...chemo- therapeutic agents, and at the very least inhibition of excystment process would impede ...
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Press-pulse: a novel therapeutic strategy for the metabolic management of cancer
... press-pulse therapeutic strategy for the metabolic management of cancer will depend on optimization of the scheduling, dosing, and timing of the various diets, drugs, and procedures used in order to achieve ...
17
Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery
... of immature unspliced transcripts to high levels of active mature mRNA. BRD4 is part of the transcription pre-initiation complex and remains associated with the RNAP II transcription complex until productive elongation, ...
16
Induction of Cellular Senescence As A Novel Therapeutic Strategy for Melanoma Treatment
... novel therapeutic strategy for patients with advanced melanoma, and suggest that pro-senescence therapy should be combined with other targeted therapies or immunotherapies to maximize cell ...
146
Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?
... Whether spontaneous periodontal disease induced bacteraemia or periodontal inter- vention procedure induced bacteraemia are still unclear. Whether periodontal inter- vention can be used as a potential therapeutic ...
13
Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury
... Acute lung injury (ALI) is characterized by the influx of protein-rich edema- tous fluid into the airspaces due to increased permeability of the alveolar- capillary barrier. Inflammatory mediators are thought to play a ...
5
NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma
... vulnerability to nicotinamide adenine dinucleotide (NAD+) depletion in IDH1/2 mutant cells, demonstrated by an increased sensitivity for nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. This increased ...
28
Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease
... Abstract: Chronic obstructive pulmonary disease (COPD) progresses very slowly and the majority of patients are therefore elderly. COPD is characterized by an abnormal persistent inflammatory response to noxious ...
12
Recanalisation therapy in patients with acute ischaemic stroke caused by large artery occlusion: choice of therapeutic strategy according to underlying aetiological mechanism?
... ative LAO in patients with AIS. Cardioembo- lism (CE), in situ thrombosis (IST) on the surface of a vulnerable atherosclerotic plaque with severe or slight stenosis, chronic ather- osclerotic occlusion, artery-to-artery ...
7
Alternative RNA splicing: contribution to pain and potential therapeutic strategy
... potential therapeutic strategy because these molecules might control limited down- stream splicing events, reducing the possibility of off-target or other adverse effects ...
12
The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease
... WORLD JOURNAL OF SURGICAL ONCOLOGY Numata et al World Journal of Surgical Oncology 2012, 10 109 http //www wjso com/content/10/1/109 RESEARCH Open Access The clinicopathological features of colorectal[.] ...
8
Manipulation of autophagy: a novelly potential therapeutic strategy for retinal neovascularization
... autophagy in RVECs under physical hypoxia was associ- ated with enhanced cell migration and capillary formation. Besides, angiogenesis of RVECs was weakened in the hypoxia+ 3-MA group when compared with the control ...
12
MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer
... promising therapeutic targets toward the generation of a gene therapy approach with clinical significance for this ...combined strategy could be of great importance for therapeutic application in ...
15
Assessment of antioxidant potential of Tinospora cordifolia (Stem extract) as a therapeutic strategy
... The resultant extraction was used to determine the enzymatic antioxidants Superoxide Dismutase, Catalase, Glutathione Peroxidase, Glutathione S transferase transfer and Non-enzymatic enz[r] ...
5
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.
... Background: Ewing sarcoma and desmoplastic small round cell tumors (DSRCT) are rare and clinically aggressive sarcomas usually characterized by oncogenic fusion proteins involving EWS. Emerging studies of Ewing sarcoma ...
9
Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases
... In this study, we have performed comprehensive metabo- lomics profiling of Epi and SC adipose tissues isolated from WT and Fst-Tg mice to identify key metabolites that are differentially present in these tissues and ...
20
Bromodomain protein inhibition: a novel therapeutic strategy in rheumatic diseases
... in decreasing the arthritis scores in CIA mice and rats, as well as in mice with collagen antibody-induced arthritis.37 The beneficial effects of BET inhibitors in arthritis models in vi[r] ...
10
Watch-and-Wait as a Therapeutic Strategy in Rectal Cancer.
... tumours. Habr-Gama et al. did a retrospective study assessing the outcomes of a W&W strategy on patients with cT2N0 rectal adenocarcinoma, less than 7 cm from the anal verge, following two different regimen of ...
19
Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease
... errors across the 5 blocks of testing of day 2 (1 block = 3 trials). 3xTg-AD Veh mice committed a higher number of reference errors throughout the 5 blocks of testing compared to all the other groups. c Mean total errors ...
14
Targeting NAMPT as a therapeutic strategy against stroke
... 1 Therapeutic strategies targeting NAMPT against ...a therapeutic target against stroke from five potential therapeutic strategies: NAMPT overexpression, recombinant NAMPT, NAMPT activators, NAMPT ...
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