Thioredoxin Reductase
Compensatory Neuroprotective Response of Thioredoxin Reductase Against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation
... and thioredoxin reductase (TrxR) activity were analyzed in rat spinal cords homogenates. The severity of EAE clinical coincided with the climax of ONS, based on the increase of superoxide anion and lipid ...
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Prospective Clinical Application of Thioredoxin Reductase as a Novel Diagnostic Tumor Marker
... TR activity was determined spectrophotometrically by monitoring the NADPH-dependent production of 2-nitro- 5-thiobenzoate (extinction coefficient of 13.600 −1 cm −1 ) at 412 nm and at 37 ˚C. This was achieved using a 1 - ...
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Perisic, Tamara (2010): Addressing the Role of Mitochondrial Thioredoxin Reductase and xCT in the Maintenance of Redox Homeostasis. Dissertation, LMU München: Fakultät für Biologie
... mitochondrial thioredoxin reductase (Txnrd2) were created (Conrad et ...mitochondrial thioredoxin reductase is essential for embryonic development, increased apoptosis of haematopoietic cells ...
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B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy
... The thioredoxin (Trx) system, composed of thioredoxin reductase (TrxR), Trx, and NADPH, is a major cellular redox control mechanism that is often deregulated in malignancy ...
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The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways
... [5–7], thioredoxin reductase 1 (Txnrd1, TR1) [8], and glutathione peroxidase 2 (GPx2) ...a reductase for incorrectly formed disulfide bonds in misfolded glycoproteins bound to ...
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EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells
... the thioredoxin reductase 1 (TrxR1), an important selenocysteine (Sec)-containing antioxidant enzyme, to induce reactive oxygen species (ROS)-mediated apoptosis in human gastric cancer ...
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Original Article Expression of thioredoxin reductase-1 and its effect in non-small cell lung cancer
... Lung cancer is the leading cause of cancer death throughout the world, and non-small cell lung cancer (NSCLC) accounts for 85% [1]. NSCLC is less responsive to chemotherapy and radiotherapy and the targeted therapy of ...
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Paraquat increases cyanide insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase
... Attempts to ameliorate paraquat-induced lung toxicity have met with mixed success. Although anti-inflammatory cortico- steroids are commonly administered, there is limited evidence that these compounds provide ...
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Hellfritsch, Juliane (2011): Loss of mitochondrial thioredoxin reductase delays angiogenic switch and impairs tumour growth. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the thioredoxin-dependent ...oxidoreductase thioredoxin (Trx). Thioredoxin and its co-operating molecules are ubiquitous in archea, bacteria and ...mitochondrial thioredoxin reductase ...
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Imbalance in superoxide dismutase/thioredoxin reductase activities in hypercholesterolemic subjects: relationship with low density lipoprotein oxidation
... [7]. Thioredoxin reductase (TrxR-1) is a redox- active selenoprotein that efficiently regenerates oxidized thioredoxin protein (Trx-1) to its reduced form ...
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Thioredoxin reductase: A novel, independent prognostic marker in patients with hepatocellular carcinoma
... Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively ...
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Comparison of different forms of dietary selenium supplementation on gene expression of cytoplasmic thioredoxin reductase, selenoprotein P, and selenoprotein W in broilers
... ABSTRACT: Effects of different forms of dietary selenium (Se) supplementation on gene expression of cyto- plasmic thioredoxin reductase (TrxR1), selenoprotein P (SelP), and selenoprotein W (SelW) in ...
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Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
... cytoplasmic thioredoxin system. Thioredoxin reductase 1 (TXNRD1) reduces thioredoxin 1 (TXN), which in turn reduces oxidized cysteins in cellular proteins and scavenges peroxides by ...
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Mutation of the cys-9 Gene, Which Encodes Thioredoxin Reductase, Affects the Circadian Conidiation Rhythm in Neurospora crassa
... Period lengths and mycelial growth rates of cysteine auxotrophs: Ten cysteine auxotrophs were examined with regard to the period lengths of their circadian conidiati[r] ...
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Sulforaphane-induced transcription of thioredoxin reductase in lens: possible significance against cataract formation
... antioxidant enzymes. This investigation provides early evi- dence of this possibility. This hypothesis has been verified by culturing mouse lenses with and without sulforaphane and then measuring the activity of TrxR, a ...
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Thioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1
... We have shown that transcript levels of gapB and glyceral- dehyde-3-phosphate dehydrogenase (GAPDH) activity are significantly increased 1.7-fold and 3-fold, respec- tively, upon overexpression of trxB1 and hydrogen ...
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A New Member Of The Thioredoxin Reductase Family From Early Oxygenic Photosynthetic Organisms.
... Trx reductase (TR) family (Jacquot et al., 2009). NADP-dependent Thioredoxin Reductases (NTRs), the most common type, belong to the family of dimeric pyridine nucleotide disulfide oxidoreductase ...
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Synergistic effect of thioredoxin and its reductase from Kluyveromyces marxianus on enhanced tolerance to multiple lignocellulose-derived inhibitors
... of thioredoxin family from K. marxianus, composed of thioredoxin and its reductase, under harshest conditions (high ROS and ethanol) may be regarded as a potential target for an enhanced toler- ance ...
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The thioredoxin system of Helicobacter pylori
... of thioredoxin reductase (TR) and the characterization, purification, and cloning of thioredoxin (Trx) from Helicobacter py- ...encoding thioredoxin re- vealed that it is a 12-kDa protein ...
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Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation
... by thioredoxin reductase (TR) using electrons from reduced nicotinamide adenine dinucleotide phosphate (NADPH) ...by thioredoxin interacting protein (TXNIP) via a redox-dependent interaction ...
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