thogoto virus
Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1.
... tick-transmitted Thogoto virus is sensitive to interferon-induced nuclear Mx1 protein, which is known for its specific antiviral action against ...Influenza virus-susceptible BALB/c mice (lacking a ...
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In Vivo Conditions Enable IFNAR-Independent Type I Interferon Production by Peritoneal CD11b+ Cells upon Thogoto Virus Infection
... upon virus infection binds the IFNAR and activates a self-enhancing positive feed- back loop, resulting in induction of large, protective amounts of ...orthomyxovirus Thogoto virus ...derived ...
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In vitro polymerase activity of Thogoto virus: evidence for a unique cap-snatching mechanism in a tick-borne orthomyxovirus.
... Thogoto virus (THOV) has been classified within the new genus Thogotovirus of the family Orthomyxoviridae (25, 31) and is able to infect both vertebrates and ticks (reviewed in refer- ence ...The ...
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Rescue of Recombinant Thogoto Virus from Cloned cDNA
... Thogoto virus (THOV) is the prototype tick-transmitted or- thomyxovirus ...the virus to replicate in both cell ...influenza virus glycoproteins but has similarity with the surface ...
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Thogoto Virus Matrix Protein Is Encoded by a Spliced mRNA
... Thogoto virus (THOV) is a tick-borne orthomyxovirus (24) and contains a genome of six single-stranded RNA segments of negative ...the virus particle and is expressed at high levels late in infection ...
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The Interferon Antagonist ML Protein of Thogoto Virus Targets General Transcription Factor IIB
... of virus-specific molecular patterns triggers the expression of type I interferon (IFN- ␣ /  ) and thereby induces production of antiviral ...related Thogoto virus (THOV) (17, 27, ...with ...
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Novel Gene Product of Thogoto Virus Segment 6 Codes for an Interferon Antagonist
... Thogoto virus (THOV) is the prototype of tick-transmitted orthomyxoviruses (28). It was independently isolated from ticks that were collected in Africa, Asia, and southern Europe (25). The genome of THOV ...
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Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells
... with Thogoto virus (THOV), which is an influenza virus-like orthomyxovirus transmitted by ticks, mounted sustained IFN responses that persisted up to 72 h after ...
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The 5' ends of Thogoto virus (Orthomyxoviridae) mRNAs are homogeneous in both length and sequence.
... THO virus-infected cells were again passed through an oligo(dT) column, and fractions that corresponded to RNA that eluted with ...THO virus- infected cells and (ii) a GTP-initiated SP6-derived RNA tran- ...
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Nucleoprotein viral RNA and mRNA of Thogoto virus: a novel "cap-stealing" mechanism in tick-borne orthomyxoviruses?
... influenza virus (29), and that a viral or cellular mechanism generates the ...influenza virus (49a) which is implicated in cap binding and cleaving of the primer RNA ...influenza virus (25, ...
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Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus.
... Europe. Thogoto (THO) and Dhori (DHO) viruses represent a group of arboviruses that are ge- netically related to the influenza viruses and have been as- signed to a separate genus, so far ...THO virus was ...
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An Endonuclease Switching Mechanism in the Virion RNA and cRNA Promoters of Thogoto Orthomyxovirus
... Thogoto virus (THOV) has been classified within the new genus Thogotovirus of the family Orthomyxoviridae (25) and can infect both vertebrates and ...The virus is structurally and genetically similar ...
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Striking conformational similarities between the transcription promoters of Thogoto and influenza A viruses: evidence for intrastrand base pairing in the 5' promoter arm.
... reconstituted Thogoto virus (THOV) cores which provided evidence of a double-stranded vRNA promoter consisting of both the 3 * and 5 * sequences of vRNA ...A virus (FLUA) vRNA-like promoter, as well ...
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A Monomeric GTPase-Negative MxA Mutant with Antiviral Activity
... The interferon-induced human MxA protein belongs to the group of large GTP-binding proteins that includes dynamin and the human guanylate-binding protein 1 (GBP1) (17, 26, 27). A common feature of these proteins is their ...
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Persistent Gene Expression in Mouse Nasal Epithelia following Feline Immunodeficiency Virus-Based Vector Gene Transfer
... syncytial virus, parainfluenza virus, and measles virus) and orthomyxoviruses ...influenza virus A and B) are well studied and known to enter and replicate in airway ...(influenza virus ...
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Upolu virus and Aransas Bay virus, Two Presumptive Bunyaviruses, Are Novel Members of the Family Orthomyxoviridae
... species Thogoto virus. The species Dhori virus includes two viruses, DHOV and BKNV, which share approximately 97% and 90% amino acid (87% and 80% nucleotide) identity among their available partial NP ...
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Evolutionary Relationships and Systematics of the Alphaviruses
... Chikungunya virus is believed to have originated in East Africa in a nonhuman primate-sylvatic Aedes mosquito transmission cycle and later was introduced into Asia along with the urban vector Aedes aegypti ...
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The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus
... extracellular virus production. Furthermore, plaque development for each virus was photographed under UV light on a daily ...wild-type virus (data not ...recombinant virus and com- pared them ...
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Investigating the antigenicity of the lyssavirus glycoprotein
... the virus initially replicates in muscle cells at the site of the wound (Bellinger et ...1993). Virus RNPs are able to travel along axons in a retrograde fashion at a rate of 50-100mm/day (Tsiang et ...The ...
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Ebola and zika virus
... Zika virus genetics: There are two lineages of Zika virus, the African lineage and the Asian lineage (Kuno et ...Zika virus from Brazil and Suriname have been published (Haddow et ...Zika ...
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