THP-1 monocytes
Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes
... This is the first report to demonstrate that the mostly monomeric soluble form of Aβ1-42 negatively regulates the innate immune system by down-regulating the se- cretion of S100A9, which subsequently reduces the ...
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Intracellular Infections Enhance Interleukin-6 and Plasminogen Activator Inhibitor 1 Production by Cocultivated Human Adipocytes and THP-1 Monocytes
... and THP-1 monocytes can be infected by adenovirus 36, CMV, and influenza A ...but THP-1 monocytes are refractory to this virus ...in monocytes by adenovirus 36 and CMV was ...
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A proteomic analysis of C-reactive protein stimulated THP-1 monocytes
... Figure 4 Quantitative analysis of differentially expressed proteins. A. mCRP induces expression of cellular stress related proteins of the ubiquitin/proteasome system and the heat shock response. Expression levels of ...
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Phellinus linteus polysaccharide extracts increase the mitochondrial membrane potential and cause apoptotic death of THP-1 monocytes
... converted THP-1 monocytes into macrophages ...extract-treated THP-1 cells could absorb (fluorescent) latex particles of 1 μm diameter analogously to PMA activated ...
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Human Cytomegalovirus Chemokine Receptor Gene US28 Is Transcribed in Latently Infected THP-1 Monocytes
... differentiated THP-1 ...undifferentiated THP-1 monocytes, we set out to determine whether US28 transcription also oc- curs in differentiated ...First, THP-1 cells were ...
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II. Voltage-activated Proton Currents in Human THP-1 Monocytes
... undifferentiated THP-1 cells stimulated acutely with LPS are already capable of O 2 − production (Leibbrandt & Koropatnick, 1994) as large or larger than that measured in cultured human monocytes ...
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I. Ion Channels in Human THP-1 Monocytes
... Micropipettes were pulled in several stages using a Flaming Brown automatic pipette puller (Sutter Instruments, San Rafael, CA) from EG-6 glass obtained from Garner Glass (Claremont, CA). Pipettes were coated with ...
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Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.
... in THP-1 ...namely THP-1 ...PB monocytes into macrophages, the 12,13-phorbol myristyl acetate (PMA)-induced transition of THP-1 ‘monocytes’ to ‘macrophages’ was ...
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III. Ion Channel Expression in PMA-differentiated Human THP-1 Macrophages
... when induced by PMA to differentiate into macrophages, but not when induced to differentiate along the granulo- cyte lineage (Wieland et al., 1990). Rat osteoclasts with spread morphology expressed I IR , whereas those ...
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Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor
... microenvironment. THP-1 monocytes were one of most widely used cell lines to investigate the function and regulation of monocytes and macrophages, and an important tool to mimic the ...
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Mebendazole induced M1 polarisation of THP 1 macrophages may involve DYRK1B inhibition
... untreated THP-1 monocytes. However, in THP-1 cells differentiated into macrophages, AZ191 strongly induced a pro-inflammatory cytokine release pattern similar to MBZ and ...in ...
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Analysis of Lipoprotein(a) Receptors: Roles in Catabolism and Pericellular Plasminogen Activation
... It has been previously shown that Lp(a)/apo(a) can inhibit pericellular plasminogen activation on HUVECs, THP-1 monocytes, and THP-1 cells differentiated into macrophages [18]. However, ...
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Lipopolysaccharide induces the expression of an autocrine prolactin loop enhancing inflammatory response in monocytes
... of monocytes towards Mϕ phenotype as much as possible, we performed dose-response assays using LPS from Salmonella enterica serotype Minnesota and Escherichia coli 0111: B4 (Additional file 1: Figure ...
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Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans
... and THP-1 human monocytes, the protein level of se- creted Sap5 was far more than the secreted Sap6 (Buu, unpublish), however, reduced capability of filamentous growth was found in Δsap6 strain of ...
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FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism
... Acute myeloid leukemia (AML) comprises a heterogeneous group of clonal disorders of hematopoietic progenitors. We previously showed that heme oxygenase-1 (HO- 1/Hsp32) underlies resistance of AML to ...
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Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles
... Table 2 summarise the number of total granulocytes in the bronchoalveolar lavage fluid in the lungs of rats treated at 150 cm 2 /rat after 24 h of instillation. Table 3 summarise the utility of the various in vitro ...
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Characterization of Pichinde virus infection of cells of the monocytic lineage.
... To establish a model of monocytic infection by Pichinde virus, we screened human peripheral blood monocytes PBM and two human cell lines, the promonocytic leukemia cell line THP-1 37 and[r] ...
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Characterization of Simian Immunodeficiency Virus SIVSM/Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells
... tion, monocytes were infected right after thaw in the absence of exogenous cytokines, and PBLs were infected after 24 h of stimulation with ...of monocytes that were analyzed 5 to 7 days after infection, as ...
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Ebola Virus Exploits a Monocyte Differentiation Program To Promote Its Entry
... that monocytes are productively infected by EBOV but are nonpermis- sive for EBOV GP-mediated entry (4, ...DCs), monocytes become permissive for entry by 48 h after cytokine addition ...that ...
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CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes
... with 1% penicillin/streptomycin and 2% L- glutamine (Gibco) and with 10% FBS at 37°C in a humidified atmosphere of 5% CO 2 ...a 1:3 ratio and were re-cultured in DMEM under the same condi- ...
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