Thromboxane A2
Persistence of thromboxane A2 like material and platelet release inducing activity in plasma
... During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its ...
5
Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)
... The thromboxane A2 receptor (TBXA2R) is a seven-transmembrane domain-spanning G-protein coupled receptor (GPCR) predominantly expressed in platelets and involved in platelet activation and aggregation, but ...
15
Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder
... receptors. Thromboxane A2 (TXA2) receptor is a member of the family of G protein-coupled receptors and performs an essential role in hemostasis by interacting with TXA2 to induce platelet ...
7
Two thromboxane A2 receptor isoforms in human platelets Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation
... Thromboxane A2 (TXA2) receptor is a key molecule in hemostasis as its abnormality leads to bleeding ...phospholipase A2 activation which remain unaffected in the patients with this ...
9
Acetyl glyceryl ether phosphorylcholine stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs Role of thromboxane A2
... release thromboxane A2 (TXA2), which then produces pulmonary hypertension and lung ...a thromboxane synthetase blocker, prior to infusion with AGEPC significantly diminished pulmonary hypertension ...
8
Coronary vascular occlusion mediated via thromboxane A2 prostaglandin endoperoxide receptor activation in vivo
... the thromboxane A2/prostaglandin endoperoxide receptor. Thromboxane A2/prostaglandin endoperoxide receptor antagonists are compounds with therapeutic potential which represent a novel approach ...
8
Predominant functional roles for thromboxane A2 and prostaglandin E2 during late nephrotoxic serum glomerulonephritis in the rat
... inhibitor, ibuprofen (n = 6) or a thromboxane A2 (TxA2) receptor antagonist, L-670,596 (n = 5). A mesangial macrophage/monocyte infiltrate was noted with equal intensity in all NTS- treated rats. Glomerular ...
10
Aggregating human platelets cause direct contraction and endothelium dependent relaxation of isolated canine coronary arteries Role of serotonin, thromboxane A2, and adenine nucleotides
... and thromboxane A2 contribute to the direct activation of coronary smooth muscle by aggregating human platelets, whereas adenine nucleotides are the principal mediators of the endothelium-dependent ...
7
Indomethacin in vivo increases the sensitivity to Listeria infection in mice A possible role for macrophage thromboxane A2 synthesis
... specific thromboxane synthase inhibitor, OKY1581, and those not receiving either drug, were found as early as 2-4 h after ...stable thromboxane A2 analog or another potent ...
6
Abnormal platelet response to thromboxane A2
... a thromboxane A2 (TXA2) ...the thromboxane synthetase level. Furthermore, thromboxane B2 (TXB2) formation in the propositus' platelets ...
5
Efficacy of Seratrodast, a Thromboxane A2 Receptor Inhibitor in a Double Blind Comparative Clinical Trial with Monteluklast
... Asthma is one of the most common chronic diseases, characterized by infiltration of various inflammatory cells including eosinophils, T lymphocytes and mast cells in airway smooth muscle [1]. Activation of these cells ...
13
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2
... receptors. TP receptors have been implicated in the pathogenesis of cardiovascular diseases. To investigate the physiological functions of TP receptors, we generated TP receptor-deficient mice by gene targeting. Tp-/- ...
9
Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice
... In addition, we assessed hepatic glutathione content and the expression of cell death-related markers in the APAP treated mice, as well as CYP2E1 activity in mouse liver microsomes.. Fur[r] ...
10
Synthesis of thromboxane A2 analogues
... A shorter synthesis of the carbocyclic thromboxane (18) (Scheme 7) was published by Nicolaou's group. [40] The key step in the synthesis was the organocupiate conjugate addition to the a , 3 unsaturated aldehyde ...
219
Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator Effects of simultaneous inhibition of thromboxane A2 synthase and blockade of thromboxane A2/prostaglandin H2 receptors in a canine model of coronary thrombosis
... To determine whether these mechanisms might affect the thrombolytic activity of t-PA and the incidence of reocclusion after thrombolysis, we compared the effects of simultaneous inhibiti[r] ...
9
Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus
... We have examined the urinary excretion of stable immunoreactive eicosanoids in 23 female patients with systemic lupus erythematosus (SLE), 16 patients with chronic glomerular disease (CGD), and 20 healthy women. SLE ...
9
Distinct platelet thromboxane A2/prostaglandin H2 receptor subtypes A radioligand binding study of human platelets
... ['25I]BOP was used in binding studies to washed human platelets to further investigate the possibility that human platelets possess distinct subtypes of TXA2/PGH2 receptors that may repr[r] ...
10
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet derived COX 1/thromboxane A2
... Prostanoids are a family of bioactive lipids comprising prostaglandins (e.g., PGD 2 , PGE 2 , PGF 2a ), thromboxane A 2 (TXA 2 ), and prostacyclin (PGI 2 ). The rate-limiting step of prostanoid biosynthesis is ...
19
Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE deficient mice
... It is now understood that atherosclerosis is an inflammation in the intima of large arteries that is triggered by high serum cho- lesterol and in which various types of cells including monocytes/ macrophages, endothelial ...
12
Role of Thromboxane A2 in the Induction of Apoptosis of Immature Thymocytes by Lipopolysaccharide
... The numbers inside the plot represent the contribution (%) of each thymocyte population to the total of gated cells: left lower quadrant, CD4 ⫺ CD8 ⫺ cells; left upper quadrant, CD4 ⫺ CD[r] ...
8