Thyroid hormone receptor β
An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell specific over expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary selective resistance to thyroid hormone
... Further studies demonstrated the absence of a pituitary adenoma and the rise in TSH following the injection of TRH. The clinical picture was interpreted as “Thyrotro- pin-induced hyperthyroidism caused by a selective ...
7
Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system
... additional possibilities warrant discussion. First, because TRβ2 is the most abundant TR isoform in the pituitary, loss of TRβ2 reduces the total number of pituitary TRs. Thus, the observed phenotype could simply ...
11
Oncogenic mutations of thyroid hormone receptor β
... The C-terminal frame-shift mutant of the thyroid hormone receptor TRβ1, PV, functions as an oncogene. An important question is whether the oncogenic activity of mutated TRβ1 is uniquely dependent on ...
17
Thyroid hormone action in the absence of thyroid hormone receptor DNA binding in vivo
... The ABR represents summed activity of cochlear afferent fibers, which, in turn, constitute the final stage in the cochlea’s transduction cascade from mechanical input (sound) into electrical output (neu- ral spike ...
11
A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
... of thyroid hor- mone action such as serum SGOT, SGPT, cholesterol, triglycerides, ferritin, osteocalcin, creatine phosphoki- nase (CPK), and sex hormone binding globulin (SHBG), also can be helpful in ...
11
Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific
... for thyroid hormone. We used the thyroid hor- mone receptor-β–selective (TR-β–selective) ligand, GC-1, to determine by a pharmacological approach whether adaptive thermogenesis ...
10
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression
... T3-dependent, TRβ1-mediated destabilization of PTTG1 occurs via the proteasomal degradation machinery. We have previously shown that the T3-induced degradation of TRβ1 is mediated by the protea- some degradation pathway ...
14
microRNA and thyroid hormone signaling in cardiac and skeletal muscle
... estrogen-related receptor γ (ERRγ), which mediates the effect of peroxi- some proliferators-activated receptors β/δ and PPARα on energy metabolism and skeletal muscle fiber specific- ity [63, ...hypo- ...
8
Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature
... goiter. Thyroid function tests showed FT4 at ...releasing hormone (TRH); liothyronine (L-T3) suppressed TSH from ...positive thyroid peroxidase antibodies (TPOAb), positive thyroglobulin antibodies ...
5
Food restriction in young Japanese quails: effects on growth, metabolism, plasma thyroid hormones and mRNA species in the thyroid hormone signalling pathway
... of thyroid hormone receptors (TRs), and several T3-mediated effects are regulated through the role of TRs as hormone inducible transcription factors for their target genes (Yen, ...these ...
8
Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells
... gating the ability of RO to suppress the growth of prostate cancer cells. In the studies reported here, RO reduced the viability of three prostate cancer cell lines: hormone- dependent LNCaP cells, as well as ...
10
Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice
... different thyroid statuses using Northern blot and ...in thyroid but not in stomach (Figure ...in thyroid, qPCR was performed and statistically significant differ- ences among control, hyperthyroid, ...
6
← Return to Article Details Extra-Thyroidal Factors Impacting Thyroid Hormone Homeostasis
... Peripheral thyroid metabolism is a complex process involving deiodination, conjugation, and lipid peroxidation ...symptom-free thyroid hormone expression depends not only on adequate thyroid ...
10
Thyroid hormone resistance syndrome Inhibition of normal receptor function by mutant thyroid hormone receptors
... beta receptor isoforms when examined in coexpression ...mutant receptor binding to DNA was unaffected, ligand binding studies showed that the G340R and delta 448-456 ...
9
Development of Thyroid Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy
... for thyroid diseases other than GD, and the pathogenesis of TAO in these other thyroid diseases is ...However, thyroid hormonal function and TSH recep- tor antibody tests, which were conducted in ...
6
Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks
... Total RNA of satellite cells was extracted, quality verified and 2 μg of total RNA was reverse tran- scribed as described previously [5]. Real-time PCR was performed to quantify the mRNA expression of GHR, IGF-I, IGF-IR, ...
9
Analysis of thyroid-stimulating hormone receptor antibodies in various thyroid diseases.
... of thyroid overstimulation (pulse rate > 170 bpm, impaired growth rate, oligoamnios, ...fetal thyroid have been defined from 20 weeks’ gestational age but require a well-trained operator, and ...
72
Evaluation of immunoglobulin G complexed form of thyroid stimulating hormone [MACRO TSH] as interference in TSH assay
... Cross reactivity occurs when some endogenous molecules have a similar structure to the measuring analyte, for example TSH and HCG carries an analogue alpha chain that can cause interference. With development of specific ...
119
A heartfelt response: new thyroid hormone–sensitive neurons in the hypothalamus
... to thyroid hormone in various target ...that thyroid hormone–dependent modulation of cardiovascular function may involve central target tissues that are critical for regulating proper ...
5
DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA 1
... CONCLUSION: Hypothyroidism is the commonest clinical disorder of thyroid function. At present there is no natural potent drug available to treat hypothyroidism. Molecular docking is one of the powerful techniques ...
6