tissue factor
Factor VIII bypassing activity of bovine tissue factor using the canine hemophilic model
... coagulation factor, factor VIII, is frequently complicated by the development of neutralizing ...glycoprotein tissue factor, a known initiator of coagulation, was investigated as a ...
7
Original Article Tissue factor is strongly expressed in pericarcinomatous tissue in patients with laryngeal carcinoma
... Abstract: Objective: This study aimed to understand the relationship between tissue factor (TF) and laryngeal carci- noma. Methods: Differences in TF expression between pericarcinomatous and carcinomatous ...
6
Tissue factor as an initiator of coagulation and inflammation in the lung
... Patients with severe infections almost invariably exhibit evidence of activation of the coagulation system. The lungs are amongst the most frequently affected organs during severe infection and sepsis. The abundant ...
9
Tissue factor in tumor microenvironment: a systematic review
... mortality. Tissue factor (TF), comprising of a 47-kDa transmembrane protein that presents in subendothelial tissues and leukocytes and a soluble isoform, have distinct roles in the initiation of extrinsic ...
8
The effects of antioxidant vitamins on the expression of tissue factor and tissue factor pathway inhibitor genes in human monocytic and endothelial cell lines
... Tissue factor pathway inhibitor is the primary physiological inhibitor that regulates tissue factor-induced blood coagulation (Pendurthi et al, ...1999). Tissue factor pathway ...
327
Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis
... Tissue factor (TF) is traditionally known as the initiator of blood coagulation, but TF also plays an important role in inflammatory processes. Considering the pivotal role of coagulation in inflammatory ...
8
Low levels of tissue factor are compatible with development and hemostasis in mice
... Tissue factor (TF) expression is associated with life-threatening thrombosis in a variety of human diseases, including sepsis, cancer, and atherosclerosis. Recently, it was shown that inactivation of the ...
11
Tissue factor expression by endothelial cells in sickle cell anemia
... The role of the vascular endothelium in activation of the co- agulation system, a fundamental homeostatic mechanism of mammalian biology, is uncertain because there is little evi- dence indicating that endothelial cells ...
7
MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes
... Background: Diabetes mellitus is characterized by chronic vascular disorder and presents a main risk factor for cardiovascular mortality. In particular, hyperglycaemia and inflammatory cytokines induce vascular ...
11
Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor induced tissue factor expression and fibrin deposition in mouse meth A sarcoma
... for tissue factor after TNF injection, based on im- munocytochemistry and in situ ...on tissue factor derived from tumor cells, since in vessels of tumors not expressing tissue ...
13
The phospholipid requirement of tissue factor in blood coagulation
... for tissue factor, we found that removal of 95% of the tissue factor-phospholipid resulted in a loss of 98% of its biological ...extracted tissue factor with either mixed brain ...
10
Association of tissue factor activity with the surface of cultured cells
... Tissue factor occurs in a dormant state on the surface of cultured normal human fibroblasts and WISH 1 amnion ...cellular tissue factor becomes active under these conditions and is released ...
12
Tissue Factor and Platelet Microparticles in Acute Myocardial Infarction
... with the MFI of CD42b + PMP and CD142 + TF+MP (r= 0.81). Further, Biasucci et al. (2012) studied variation in levels of MP in ACS. They found that endothelial tissue factor microparticles and PMP ...
5
Tissue factor as a proinflammatory agent
... Tissue factor (TF) is a transmembrane glycoprotein and the main triggering element of blood ...necrosis factor, and IL-1 and is considered to appear in consequence of ...
6
Requirement for binding of catalytically active factor VIIa in tissue factor dependent experimental metastasis
... Tissue factor (TF), the initiating cell surface receptor of the coagulation cascade, plays important roles in embryogene- sis, angiogenesis, and tumor cell ...
8
Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit
... (a) factor VII (FVIIa) with its recep- tor and cofactor, tissue factor ...only tissue factor pathway inhibitor (TFPI) is known to inhibit the FVIIa/TF ...
9
Coagulant Activity of Leukocytes TISSUE FACTOR ACTIVITY
... activates factor X in the presence of factor VII and calcium and is therefore regarded as tissue ...mg tissue factor activity was obtained from the peritoneal cavity of ...
8
The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor
... via Factor VIIa-dependent activation of Factor X, but direct proof has not been available for the participation of tissue factor in this ...recombinant Factor VIIa (approximately 50 ...
7
Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation
... MP or PMN depletion was accomplished using either rabbit anti- murine MP or antimurine PMN sera (Accurate Chemical and Science Corp.) (16, 17). Animals received daily intraperitoneal injections (0.3 ml) for 3 d. Wright ...
11
Determination of Plasma Tissue Factor Antigen and Tissue Factor-Bearing Microparticles Activity in Healthy Subjects
... TF expression has been reported in a number of cancers, such as prostate cancer, pancreatic cancer, ovarian cancer, non–small- cell lung cancer, colorectal cancer, renal cell cancer, hepatocellular cancer, glioma and ...
7