tissue factor (coagulation factor III)
The phospholipid requirement of tissue factor in blood coagulation
... a coagulation assay specific for tissue factor, we found that removal of 95% of the tissue factor-phospholipid resulted in a loss of 98% of its biological ...extracted tissue ...
10
Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury
... and coagulation are tightly linked processes with inflammatory cytokines leading to upregulation of Tissue Factor (TF) on lung epithelial cells [10], macrophages [11, 12] and endothelial cells ...
8
Essential role of platelet activation via protease activated receptor 4 in tissue factor initiated inflammation
... human tissue factor secreted by Saccharomy- ces cerevisiae and refolded from Escherichia coli inclusion bodies: glycosylation of mutants, activity and physical ...
8
Cultured human endothelial cells generate tissue factor in response to endotoxin
... Cultured human endothelial cells generate tissue factor in response to endotoxin.. Bacterial infection is associated with disseminated intravascular coagulation and fibrin deposition in [r] ...
5
Role of tissue factor in the procoagulant and antibacterial effects of human adipose-derived mesenchymal stem cells during pneumosepsis in mice
... of coagulation in the ...of tissue factor in cancer” and “Coagulation system” in uninfected ...on coagulation-related gene expression during pneumo- nia, we infected mice with the ...
9
The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor
... via Factor VIIa-dependent activation of Factor X, but direct proof has not been available for the participation of tissue factor in this ...recombinant Factor VIIa (approximately 50 ...
7
Inhibitor of the factor VIIa tissue factor complex is reduced in patients with disseminated intravascular coagulation but not in patients with severe hepatocellular disease
... Inhibition of Factor VIIa-tissue factor activity by a plasma component(s) that requires factor Xa has been described recently. In this communication, we have developed a specific radiometric ...
6
Reinhardt, Christoph (2007): Analyses on molecular mechanisms of activation of intravascular Tissue Factor. Dissertation, LMU München: Medizinische Fakultät
... Tissue factor pathway inhibitor-1 (TFPI) represents the main physiologic inhibitor of the coagulation ...extrinsic coagulation pathway by first binding the circulating factors X / Xa and ...
110
Concanavalin A inhibits tissue factor coagulant activity
... with tissue factor preserves coagulant ...Purified tissue factor apoprotein has been recombined with mixed brain phospholipids or purified phospholipids (phosphatidyl ethanolamine or a mixture ...
6
Tissue Factor and Cancer Metastasis: The Role of Intracellular and Extracellular Signaling Pathways
... (or coagulation) cascade. One of the key proteins in coagulation is tissue factor ...enzyme factor VIIa, TF sequentially activates factor X and prothrombin, leading to fibrin ...
6
Monocyte tissue factor–dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin
... oxLDL and other bioactive lipids induce expression of the pro- coagulant protein tissue factor (TF) in monocytes/macrophages, endothelial cells, and smooth muscle cells (20–24). Consistent with these in ...
12
Tissue factor as an initiator of coagulation and inflammation in the lung
... of coagulation in healthy human lungs through activation of the TF pathway ...the coagulation system in the ...of coagulation in the bronchoalveolar space of healthy human volunteers ...pulmonary ...
9
Elevated coagulation factor levels affect the tissue factor-threshold in thrombin generation
... of coagulation by direct assessments in ...plasma. Factor XII-deficient plasma was used to avoid any contact pathway-mediated thrombin formation, which would hamper data ...
22
Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. a simulation Study
... of coagulation proteins, which does not usually result in a variability of the coagulation times in untreated subjects, is unmasked by ...the tissue factor coagulation pathway, using ...
10
Science review: Role of coagulation protease cascades in sepsis
... surface coagulation complexes of the procoagulant and anticoagulant ...The coagulation pathways are initiated by tissue factor (TF), which serves as the allosteric activator of the enzyme ...
8
Systems Biology of Blood Coagulation and Platelet Activation
... connective tissue matrix of the subendothelium. Tissue Factor (TF) at the site of vascular damage binds to minute quantities of the circulating form of activated factor ...the ...
208
Increased Thrombogenicity in Chronic Renal Failure in a Rat Model Induced by 5/6 Ablation/Infarction
... of blood samples were used for extrinsic pathway screening thromboelastometry (EXTEM) and intrinsic pathway screen- ing thromboelastometry (INTEM). Blood clot formation was evaluated with recombinant tissue ...
6
Mechanism of activation of coagulation factor XI by factor XIIa studied with monoclonal antibodies
... of Factor XIIa with Factor XI was investigated using two monoclonal antibodies, one (3Cl) directed against the heavy chain of Factor XIa and the other (5F4) against its light ...of Factor XIa ...
8
Factor VIII cross matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A
... In this paper, we highlight the potential value of an in silico predictive model of HLA class II antigen presentation as the basis for identifying patients with missense mutation hemophilia A who are at risk of ...
39
Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III
... the coagulation Factor XIII A subunit (F XIII A) is a rare autosomal recessive disorder that is characterized by a life-long bleeding tendency complicated by a difficulty in ...
6