Tissue-factor-pathway inhibitor 2
Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2
... identified tissue factor pathway inhibitor-2 (TFPI-2), a matrix associated inhibitor of cell motility, as the functional target of trypsinogen 4, which cleaved ...
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Tissue factor pathway inhibitor 2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis
... proteinase inhibitor tissue factor pathway inhibitor-2 (TFPI-2) can function as an MMP ...“classical” tissue inhibitors of MMPs (TIMPs), TFPI-2 expression in ...
11
Promoter hypermethylation and silencing of tissue factor pathway inhibitor 2 in oral squamous cell carcinoma
... encoding tissue factor pathway inhibitor-2 ...protease inhibitor and placental protein 5 [13,18,19], TFPI-2 counteracts the activity of several extracellular matrix ...
13
Reduced expression of tissue factor pathway inhibitor-2 contributes to apoptosis and angiogenesis in cervical cancer
... Surgically resected tissue samples were routinely fixed in 10% formalin solution, paraffin-embedded, and cut into 4- μ m-thick sections. After deparaffinization and rehydration, the sections were heated in three ...
9
Upregulated matrix metalloproteinase-2 and downregulated tissue factor pathway inhibitor-2 are risk factors for lymph node metastasis and perineural invasion in pancreatic carcinoma
... and tissue factor pathway inhibitor (TFPI)-2 is closely associated with tumorigenesis and tumor ...paraffin-embedded tissue samples containing pancreatic carci- noma tissues and ...
8
Pro-coagulant activity during exercise testing in patients with coronary artery disease
... analyzed: tissue factor pathway inhibitor (TFPI) activity and antigen, prothrombin fragment 1 + 2 (F1 + 2), D-dimer and endogenous thrombin potential ...
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The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (ADTRP) gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese
... To determine the impact of the ADTRP genetic variant on plasma FVIIc and fibrinogen, we conducted the ana- lysis in a group of healthy subjects who were free from CAD at the time of recruitment. In total, 421 adult sub- ...
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The effects of antioxidant vitamins on the expression of tissue factor and tissue factor pathway inhibitor genes in human monocytic and endothelial cell lines
... Agarose gel electrophoresis was used for the separation, size determination and quantitation of DNA fragments. In most cases, DNA was separated on a 1% or 2% (w/v) agarose gel. The required amount of agarose was ...
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Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits
... z 2 h before the com- mencement of the experimental ...Renal tissue and blood were collected 72 h af- ter initiation of GN and urine was collected for the preceding 24 ...
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Further insight into the heparin-releasable and glycosylphosphatidylinositol-lipid—anchored forms of tissue factor pathway inhibitor
... not extensively studied, TFPIβ is not heparin- releasable but, rather, is GPI anchored and probably acts as a direct vessel wall anticoagulant. Therefore, the aims of this study were to (1) validate the conditions ...
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The effects of tissue factor pathway inhibitor and anti-b-2-glycoprotein-I IgG on thrombin generation
... coagulation inhibitor that inhibits the factor VII-tis- sue factor complex also inhibits factor Xa: insight into its possible mechanism of ...
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The effects of tissue factor pathway inhibitor and anti beta 2 glycoprotein I IgG on thrombin generation
... with increased in vitro TF-induced thrombin generation. The precise relationship and/or interactions between anti-β2GPI antibodies, TFPI and potentially other as yet unidentified entities, remains to be determined. The ...
7
A preliminary estimation of tissue factor pathway inhibitor (TFPI) and protein C in patients with intracranial tumors
... The present observation of high protein C activity, along with a high TF concentration, in the blood of patients suf- fering from intracranial tumors becomes especially im- portant in conjunction with the research ...
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Anti tissue factor pathway inhibitor activity in patients with primary antiphospholipid syndrome
... TFPI activity in normal plasma was 100% inhibited after 30 min at 378C by the addition of a polyclonal rabbit anti- human TFPI antibody (10 mg/ml). When the IgG fractions from the five selected patients was mixed with ...
5
Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit
... Measurement of FVII activity. Blood was collected in citrate from embryos via direct cardiac puncture. After centrifugation at 3,000 rpm for 10 min, plasma was collected and stored at –20°C until analysis. Factor ...
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Tissue Factor and Other Hemostatic Parameters in Patients with Advanced Peripheral Artery Disease After Endovascular Revascularization – Search for Hemostatic Factors which Indicate Restenosis
... + 2 (PF 1 + 2), D-dimers, fibrinogen, von Willebrand factor (vWF), tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) as well as proteins C (PC) and S (PS) ...
6
A novel anticoagulant activity assay of tissue factor pathway inhibitor I (TFPI)
... There is now convincing evidence from in vitro and in vivo experiments that TFPI plays an important role in regulating the initiation of blood coagulation [2–7]. In man, some studies have found that low levels of ...
8
Anti-tissue factor pathway inhibitor activity in subjects with antiphospholipid syndrome is associated with increased thrombin generation
... assay, test or standard plasmas were heated at 56˚C for 15 minutes, placed on melting ice for 2 minutes then centrifuged for 15 minutes at 1,800 g. Diluted test or standard plasma (25 µL) was incubated with 100 µL ...
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Original Article Correlation and prognostic significance of MMP-2 and TFPI-2 differential expression in pancreatic carcinoma
... and tissue factor pathway inhibitor (TFPI)-2 not only correlate with tumorigenesis, but also with tumor invasion and ...predictive factor for poor DFS (P = 0.01); and low ...
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Anti tissue factor pathway inhibitor activity in subjects with antiphospholipid syndrome is associated with increased thrombin generation
... assay, test or standard plasmas were heated at 56˚C for 15 minutes, placed on melting ice for 2 minutes then centrifuged for 15 minutes at 1,800 g. Diluted test or standard plasma (25 µL) was incubated with 100 µL ...
6