tissue homeostasis
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis
... dependent, tissue homeostasis in adult Fgfr2 cn prostates was less androgen dependent; androgen deprivation failed to induce tissue degeneration in adult Fgfr2 cn prostates within 2 ...regulates ...
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Pivotal regulators of tissue homeostasis and cancer: macrophages
... of tissue homeostasis, through the clearance of dam- aged cells and tissues and the repair of ...into tissue in response to inflammation or in the steady ...long-lived tissue- specific ...
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Regulation of Tissue Homeostasis by Innate Lymphoid Cells
... airway tissue homeostasis in response to influenza virus-induced damage will be a central focus of Chapters 2 and 3 of this ...acute tissue damage and triggers development of chronic type ...
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A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis
... In order to ensure tissue homeostasis under physiological stress conditions, the liver relies on its enormous regenerative capacity. Acute injury such as paracetamol poisoning or surgical removal of parts ...
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Wnt signaling in development and tissue homeostasis
... Wnt proteins are secreted growth factors that regulate the proliferation and differentiation of stem and progenitor cells, both during embryonic development and during adult tissue homeostasis in ...
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Polyploidy in tissue homeostasis and regeneration
... to tissue injury, or by failed mitosis (mitotic ...and tissue homeostasis in the absence of ...protective tissue envelopes and barriers (Orr-Weaver, 2015), possibly because tissues formed by ...
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Interleukin-22 Regulates Immunity, Inflammation and Tissue Homeostasis at Mucosal Sites
... At mucosal sites, a single layer of epithelial cells separates the connective tissues of the mammalian body from the external environment. The gastrointestinal tract is the largest mucosal surface exposed to the ...
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Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee
... Ligands for sex hormones can be generated by specific organs (endocrine system) and transported by the circu- lation to reach various target tissues, produced locally by cells such as macrophages and synthesized locally ...
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The Role of ΑV integrins in Human Skin Tissue Homeostasis, Wound Healing and Squamous Cell Carcinoma
... Much effort has been focused on defining roles for individual integrin subunits in epidermal homeostasis. As integrin signaling requires an intact, structurally correct basement membrane zone lacking in ...
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Novel therapeutic Strategies for Targeting Liver Cancer Stem Cells
... Conserved from Drosophilia to humans, the Hedgehog (HH) pathway has a central role in em- bryonic development and adult tissue homeostasis by controlling cell fate specification and pattern for- mation [49, ...
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Microglia in steady state
... other tissue macrophages, microglia have a large cell surface area; for example, the perimeter of a hippocampal microglial cell is seven times that of a Kupffer cell in the liver ...of tissue ...
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Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice
... VEGF, FGF2 and EDN1 are mainly involved in processes like angiogenesis, lung development, blood vessel devel- opment and cell proliferation. As suggested by our analy- sis (Figure 4) the cascade ends at VEGF via the FGF2 ...
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Ehrlichia chaffeensis TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection
... ABSTRACT Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes. The mechanisms involved in E. chaffeensis in- fection of the host cell and evasion of host ...
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The analysis, roles and regulation of quiescence in hematopoietic stem cells
... Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of efficient self-renewal and differentiation; some of these have been shown to exist in a dormant, or quiescent, ...
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... affects tissue homeostasis, its increased expression result- ing in cell survival, leading to tumor-genetic conditions ...that tissue homeostasis is seriously impaired with CsA-induced GO, the ...
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Combined Theraputic Potential of Spotted Wintergreen and Botanical Oils in Dermatology.
... 47 promote wound tissue homeostasis and healing, and the use of botanical oils with distinct fatty acid profiles as carrier oils that work synergistically with spotted wintergreen to f[r] ...
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Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer
... in tissue homeostasis, apoptosis and autophagy under genotoxic stresses, but it is unclear whether single nucleotide polymorphisms (SNPs) of genes in these pathways play a role in platinum-based ...
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Synovial tissue macrophages: friend or foe?
... synovial tissue includes a lining layer of synovial fibroblasts and ...synovial tissue macrophage numbers recede to ...of tissue macrophages in the lining layer of the synovial membrane in healthy ...
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Amputation induces stem cell mobilization to sites of injury during planarian regeneration
... long-term tissue homeostasis of the host versus donor cells, we attempted to rescue lethally irradiated asexual planaria with healthy grafts from the genetically distinct sexual ...of tissue ...
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Notch controls urothelial integrity in the mouse bladder
... and tissue homeostasis and upon deregulation in disease ...bladder tissue samples has indicated that reduced expression of the TJ protein zonula occludens-1 (ZO-1) (12) as well as several ...
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