TLR 9
Association between <em>TLR-9</em> polymorphisms and colon cancer susceptibility in Saudi Arabian female patients
... the TLR-9 genotype distribution for correlations with age, gender, and tumor localization revealed that there were no significant differences ...three TLR-9 SNPs (rs187084, rs352139, and ...
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Genetic variation of TLR 4, TLR 9 and TIRAP genes in Iranian malaria patients
... (TLR-2, TLR-4, and TLR-9) are central mediators of pro-inflammatory responses to Plasmodium infection ...of TLR-2 and TLR-4 inducing pro-inflammatory responses ...
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Toll-Like Receptor 7 (TLR-7) and TLR-9 Agonists Improve Hepatitis C Virus Replication and Infectivity Inhibition by Plasmacytoid Dendritic Cells
... and TLR-9 ...After TLR-7 and TLR-9 stimulation, inhi- bition of infectivity and IFN- ␣ production by pDCs were ...enhanced. TLR-7 stimulation drove higher TNF-related ...
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Gene and protein expression of tlr 9 with lipopolysaccharide in human bronchial epithelial cells
... Though the results were observed to be a trace in gene expression it was clearly visible that gene has been expressed to add more support to this statement protein expression was carried out. In the protein expression ...
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Original Article Bifidobacterium regulates TLR-4 and TLR-9 expressions in diarrhea rat caused by antibiotics
... test TLR-9 mRNA expression in mesenteric lymph nodes, intes- tine, and ...liver. TLR-9 mRNA expression signifi- cantly reduced in mesenteric lymph nodes, intestinal, and liver from diarrhea ...
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Toll-like receptors TLR-2, TLR-4, TLR-7, and TLR-9 in tumor tissue and serum of the patients with esophageal squamous cell carcinoma and gastro-esophageal junction cancer
... of TLR-2, TLR-4 and TLR-7, and protein concen- trations of all TLRs were significantly higher in tumor than in control tissue (p < ...tumor TLR-4 was ...of TLR-7 and protein ...
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Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation
... In humans and mice, several subtypes of DC have been described. Generally, DCs can be divided into conven- tional DC (cDC or "myeloid" mDC) and plasmacytoid DC (pDC) [3-6]. While mDC are located mainly within ...
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Hydroxychloroquine is associated with impaired interferon alpha and tumor necrosis factor alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus
... correlated with the exogenous administration of HCQ. In fact, most of the SLE patients in previous studies who showed decreased IFN-a production were receiving HCQ [11-13]. Our comprehensive study of all subsets of PBMCs ...
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Reactivation of latent HIV 1 in central memory CD4+T cells through TLR 1/2 stimulation
... on TLR-2 [62,63]. Flagellin, a TLR-5 agonist, reactivates latent HIV-1 in the cell line J-Lat ...the TLR-7/8 agonist, R-848, is able to reactivate latent HIV-1 from myeloid-monocytic cells lines ...
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B Cell Toll-like Receptors with Respect to the Pathogenesis of Sjögren’s Syndrome
... TLR9 recognizes specific unmethylated CpG-oligode- oxynucleotides (ODN) sequences that distinguish micro- bial DNA from mammalian DNA. Bacterial DNA contains unmethylated CpG motifs, while in mammalian DNA, the cytosine ...
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The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis
... as TLR-9 −/− mice. Remarkably, brains of T. gondii infected TLR-9 −/− mice were even more distinctly affected by the induced pro- inflammatory immune responses as compared to WT con- trol ...
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Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis
... (TLR-3), TLR-7, TLR-8, and TLR-9 mRNAs were evaluated, using TaqMan quantitative reverse transcription-PCR, in cells from nasopharyngeal washes collected from 157 infants suffering from ...
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Development of maternal and foetal immune responses in cattle following experimental challenge with Neospora caninum at day 210 of gestation
... and TLR-9 To determine whether TLR-2 and TLR-9 expression is be- ing up or down regulated during ...of TLR expres- sion were normalised against a reference gene GAPDH, which has ...
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From Christian de Duve to Yoshinori Ohsumi : more to autophagy than just dining at home
... In addition to its role in promoting maintenance of Treg populations, autophagy also acts to maintain central toler- ance [10] by promoting the expression of self-antigens by MHC class II on thymic epithelial cells that ...
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Original Article Macrophages polarization is mediated by the combination of PRR ligands and distinct inflammatory cytokines
... When the patterns of cytokines induced by each TLR agonist were separately analyzed, the secretion of cytokines was inconsistent due to the activation of different PRRs. Consistent with the expression levels of ...
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Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers
... of TLR-4 and age, gender, location and differentiation of tumor; however, TLR-4 levels were correlated with tumor size, lymph node involvement, venous invasion, and pathological ...between TLR-4 and ...
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Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton's jelly
... lung was analyzed. The results showed that gelatinolytic activities of total MMPs in the group of BLM+HUMSCs (HD) displayed stronger than those in the Normal and BLM groups on Day 49 (Figure 7F). In order to further ...
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The 3′ CCACCA Sequence of tRNAAla(UGC) Is the Motif That Is Important in Inducing Th1-Like Immune Response, and This Motif Can Be Recognized by Toll-Like Receptor 3
... RNAs are important in the immune response of viral infec- tion, modulation of cytokines, differentiation of T helper 1 (Th1) cells, and stimulation of cross-priming and antiviral ef- fects. Recently, different kinds of ...
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Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN α–producing and partially matured phenotype
... which TLR agonist is used, either they produce IFN-α or they develop a mature antigen-presenting phe- notype capable of stimulating antigen-specific effector memory T helper cells ...distinct TLR ligation ...
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Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia
... of TLR-1 expression after ischemic injury, either in the adult or developing ...mice, TLR-1 staining was found almost exclusively in infiltrating cells such as microglia/macrophages ...of TLR-3, ...
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