TLR4/NF- κB
Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
... body, NF-κB is highly active and specifically binds to cells, which has been proven closely related to cell growth and inflammatory reactions in the body (24, ...of NF- κB and causes an ...
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Original Article Osthole attenuates adjuvant-induced arthritis in rats by suppressing inflammation and oxidative stress via the SIRT1/TLR4/NF-κB pathway
... Osthole [7-methoxy-8-(3-methylpent-2-enyl) co- umarin] is a derivative of coumarin that is extracted from the herb C. monnieri (L.) Cusson, a well-known traditional Chinese medicine used to treat skin rashes, eczema, and ...
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Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway
... Methods: The DN rat model was generated by intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight) while 30 mM high glucose (HG)-treated podocytes were used as an in vitro DN model. The fasting blood ...
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Paeonol protects endotoxin-induced acute kidney injury: potential mechanism of inhibiting TLR4-NF-κB signal pathway
... Paeonol (purity = 98%, HPLC) were purchased from National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China). Lipopolysaccharide (LPS) from Escherichia coli 055:B5 was obtained from ...
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Original Article Increased expression of RP105 decreases cardiomyocytes hypoxia/reoxygenation injury through the TLR4/NF-κB signaling pathway
... on TLR4, MyD88 and NF-κB expression in control cardiomyo- cytes or cardiomyocytes infected with Ad-GFP or Ad-RP105 under normoxia or H/R condi- ...of TLR4, MyD88 and NF-κB via ...
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Impacts of Mild Hypothermia on LPS Mediated TLR4/NF κB Signaling Pathway in Microglia
... -brain bar- rier, and block the apoptosis, etc., thereby slowing the development speed and degree of nerve inflammatory responses in general, and gaining time for pro- tecting the nerve cell functions and further ...
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Original Article Effects of celecoxib on expression of TLR4, Hepcidin, and NF-κB in rats bearing uremia with peritoneal dialysis treatment
... immunities. TLR4 is a common TLR with wide ...14]. TLR4 is abnormally overexpressed in ch- ronic renal failure, especially during the disea- se development of diabetic ...of TLR4/NF-κB ...
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Andrographolide Suppress Tumor Growth by Inhibiting TLR4/NF-κB Signaling Activation in Insulinoma
... through NF-κB inactivation [5], and Andro also inhibits tumor cell proliferation and invasion, or induces cell apoptosis by regulating the expression of p27, CDK4, and Bcl-2 family mem- bers [8, ...9]. ...
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Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation
... that TLR4 is also implicated in hepatic steatosis and NAFLD pathogenesis ...Loss-of-function TLR4 mutant mice are resistant to diet-induced NAFLD ...for TLR4 include gut- derived endotoxin ...
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Original Article Electroacupuncture modulated the inflammatory reaction in MCAO rats via inhibiting the TLR4/NF-κB signaling pathway in microglia
... with TLR4 (1:200, Abcam, Cambridge, UK), HMGB1 (1:200, Abcam, Cambridge, UK), TRAF6 (1:200, Abcam, Cambridge, UK), IKKβ (1:200, Abcam, Cambridge, UK), or NF-κB p65 (1:200, Abcam, Cambridge, UK) at ...
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Atractylenolide I modulates ovarian cancer cell mediated immunosuppression by blocking MD 2/TLR4 complex mediated MyD88/NF κB signaling in vitro
... that TLR4/MD-2 complex-medi- ated activation of MyD88/NF-kB is the major mechanism for immunosuppression through induction of immu- nosuppressive molecules and generation of immuno- suppressive T cells by ...
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Epimedium sagittatum inhibits TLR4/MD 2 mediated NF κB signaling pathway with anti inflammatory activity
... of TLR4/MD-2 com- plex and NF-κB p65 nuclear translocation, which implied YYHs had anti-inflammatory activity on LPS-induced in- flammatory ...
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Original Article Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/ MyD88/NF-κB signaling pathway
... activating TLR4/MyD88/NF-κB signaling pathway, sugge- sting that TLR4 might be a therapeutic target for alleviating inflammation and fibrosis in PD ...of TLR4 gene could mediate ...
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Original Article The impact of TLR4 on insulin resistance and inflammatory factors in rats with polycystic ovary syndrome
... Western blot: The tissue was added with lysate and the protein was store at -20°C. The isolat- ed proteins were electrophoresed using 10% SDS-PAGE. The gel was transferred to PVDF membrane by semi-dry transfer method at ...
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Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti inflammation and anti apoptosis mechanisms in rabbits
... of TLR4 and NF-κB immunoreactivity in the ventral horn follow- ing spinal cord I/R injury and reduces the release of the pro-inflammatory cytokines TNF-α and IL-1β (known downstream effector ...
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Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways
... of TLR4, NF-κB, and NLRP3 were detected by western blot ...LPS-induced TLR4 expression and NF-κB activation were also inhibited by ...inhibiting TLR4 and NLRP3 signaling ...
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Original Article A herbal extract treats type 2 diabetes mellitus effectively by down-regulating expression of CD14
... Abstract: The incidence of Type 2 diabetes mellitus (T2DM) has increased worldwide. This study investigated the effect of a herbal extract, named as Baihu decoction (BHD), in treating T2DM by using mouse adipose cells ...
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Original Article Impact of clostridium difficile infection on immune function in patients with ulcerative colitis and the clinical nursing observation
... HMGB1/TLR4/ NF-κB signaling pathway lacks direct and valid evidence, which requires specific inhibition of related molecules for verification through in vi- tro cell ...
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Original Article Early enteral nutrition inhibits TLR4 signaling activation in rats with severe acute pancreatitis
... of TLR4 in the intestine by protecting the integrity of the intestinal epithe- lial ...that TLR4 expression on peripheral blood monocytes is altered during the early stage of AP [27], suggesting that ...
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Original Article Tripartite motif 59 improves atherosclerotic vulnerable plaque stability of ApoE (-/-) mice by regulating the NF-κB signaling pathway
... of NF-κB signal- ing pathway activity, and NF-κB also regulates TRIM protein expression in both directions [22- ...The NF-κB signaling pathway covers multi- ple factors such as ...
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