TLR4/NF-κB pathway
Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway
... [31]. TLR4/NF-κB pathway appears to play a criti- cal role in the pathogenesis with a variety of inflamma- tory conditions ...of TLR4/ NF-κB pathway has been ...
12
Lipopolysaccharide promotes lipid accumulation in human adventitial fibroblasts via TLR4-NF-κB pathway
... the NF-κB pathway to secrete cytokines, including IL-6, MCP-1 and tumor necrosis factor-α (TNF-α) ...in TLR4, the receptor of LPS, reduces aortic atherosclerosis in apoE-deficient mice ...
9
MiR 590 Inhibits Endothelial Cell Apoptosis by Inactivating the TLR4/NF κB Pathway in Atherosclerosis
... the TLR4/NF-κB pathway facilitates cell proliferation and restrained apoptosis in ox-LDL-treated ...lipoprotein; TLR4, toll-like receptor 4; NF-κB, nuclear factor kappa B; ...
10
Original Article Osthole attenuates adjuvant-induced arthritis in rats by suppressing inflammation and oxidative stress via the SIRT1/TLR4/NF-κB pathway
... Osthole [7-methoxy-8-(3-methylpent-2-enyl) co- umarin] is a derivative of coumarin that is extracted from the herb C. monnieri (L.) Cusson, a well-known traditional Chinese medicine used to treat skin rashes, eczema, and ...
9
Original Article A herbal extract treats type 2 diabetes mellitus effectively by down-regulating expression of CD14
... The CD14/TLR4-NF-κB pathway are found to be associated with various biological functions im- plicated in development of inflammation. CD14 is a lipopolysaccharide-binding protein, which ...
10
Impacts of Mild Hypothermia on LPS Mediated TLR4/NF κB Signaling Pathway in Microglia
... the TLR4/NF-κB pathway, and that mild hypothermia has a protective effect on nerve ...the TLR4/NF-κB pathway in ...(LPS)-mediated TLR4/NF-κB ...
12
Original Article The impact of TLR4 on insulin resistance and inflammatory factors in rats with polycystic ovary syndrome
... [10]. TLR4 binds to its ligand and induces activation of downstream ...signal, NF-κB, is an important part of the innate immune defense system ...the TLR4/NF-κB pathway is ...
7
Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
... body, NF-κB is highly active and specifically binds to cells, which has been proven closely related to cell growth and inflammatory reactions in the body (24, ...of NF- κB and causes an ...
9
Atractylenolide I modulates ovarian cancer cell mediated immunosuppression by blocking MD 2/TLR4 complex mediated MyD88/NF κB signaling in vitro
... bear TLR4 and MyD88, an adapter coupling TLR4 and that TLR4/ MyD88 signaling induces the synthesis of immunosup- pressive cytokines and facilitates tumor progression and immune evasion ...through ...
12
Original Article Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/ MyD88/NF-κB signaling pathway
... which NF-κB signal- ing modulated inflammatory actions ...inhibiting NF-κB and MAPK signaling ...and NF-κB ...ERK1/2, NF-κB, Akt, p-c-JUN and JNK Figure ...through ...
9
Curcumin attenuates MSU crystal induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
... of NF-κB activation, which alleviated MSU-in- duced inflammation in THP-1 ...that TLR4 mediated the initial steps of gout pathogenesis and that TLR4 expression was pivotal to MSU ...
15
Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways
... of TLR4, NF-κB, and NLRP3 were detected by western blot ...LPS-induced TLR4 expression and NF-κB activation were also inhibited by ...inhibiting TLR4 and NLRP3 signaling ...
7
Original Article Lipopolysaccharide activated TLR4/NF-κB signaling pathway of fibroblasts from uterine fibroids
... that TLR4 was expressed in uterine fibroid and UFC, and showed significantly high- er level compared to smooth muscle tissue and SMC ...[39]. TLR4 can mediate LPS-induced NF-κB signaling as ...
12
Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti inflammation and anti apoptosis mechanisms in rabbits
... via TLR4. The activation of TLR4 on microglial cell membranes by injury-induced ligands activates the transcription fac- tor NF-κB which in turn leads to the upregulation and release of a ...
11
Original Article Electroacupuncture modulated the inflammatory reaction in MCAO rats via inhibiting the TLR4/NF-κB signaling pathway in microglia
... the TLR4/NF-κB signaling path- way in ...of TLR4, HMGB1, TRAF6, IKKβ and NF-κB p65 in ...6, TLR4, HMGB1, TRAF6, IKKβ and NF-κB p65 in ...IL-1β, TLR4, ...
7
Original Article Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associatedvirus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury
... transcription of down-stream targets genes involved in atherosclerosis. We therefore exam- ined the influence of rAAV9-mediated R65 gene transfection on expression of inflammatory (TNF-α, IL-6) and endothelial cell ...
10
Original Article Osteoblastic NF-κB pathway is involved in 1α, 25(OH)
... of NF-κB p65 from cytoplasm to nuclei. Then, the NF-κB p65- siRNA was designed, constructed, and transfected into osteoblastic ...silenced NF-κB p65 gene in ...osteoblastic ...
9
NF κB, stem cells and breast cancer: the links get stronger
... how NF-κB would be required for the conversion of a luminal progenitor cell to a basal gene expression profi le in tumours originated in BRCA1 mutation ...RANKL/RANK/IKKα/ NF-κB axis as a key ...
7
Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma
... canonical NF-κB pathway based on the following observations: (a) NEK2 expression is posi- tively correlated with increased NF-κB score in primary myeloma samples; (b) more than 40% of ...
18
Original Article Toll-like receptor 3 (TLR3) functions as a pivotal target in latent membrane protein 1 (LMP1)-mediated nasopharyngeal carcinoma cell proliferation
... Of note, TLR3 silencing resulted in a dramatic decrease in the inflammatory signature within CNE1 cells. Moreover, poly (I:C) stimulation did not display enhanced NOS2, MMP9, and c-Myc expression when compared to ...
10