TLR4 signaling pathway
Lipopolysaccharide and palmitic acid synergistically induced MCP-1 production via MAPK-meditated TLR4 signaling pathway in RAW264.7 cells
... Diabetes incidence increases in people with obesity characterized as higher content of saturated fatty acid (FA). Data from type II diabetes patients with obesity shows that FA is correlated to chronic low-grade inflam- ...
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Original Article Glycine protects against non-alcoholic hepatitis by downregulation of the TLR4 signaling pathway
... ing pathway by metabolic endotoxemia in a rat model of non-alcoholic steatohepatitis ...of TLR4 and IRS-1 in liver was measured by Western Blot and ...of TLR4 in liver were significantly increased ...
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Original Article Association of polymorphisms in IL-10 and the TLR4 signaling pathway with the development of postoperative sepsis
... the TLR4/MyD88 signal- ing pathway ...the TLR4 rs10759932 locus was associ- ated with the occurrence of ...the TLR4 rs10759932 locus, the TC+CC genotype was closely related to the susceptibil- ...
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Quercetin Decreases Th17 Production by Down-Regulation of MAPK- TLR4 Signaling Pathway on T Cells in Dental Pulpitis
... the TLR4 could be a good receptor for HMGB1 on T ...that TLR4 could be involved in ST2 and IL-33 ...kinase signaling pathways that drive production of type 2 cytokines from polarized Th 2 ...
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Original Article MiR-548c inhibits lung cancer cell proliferation through suppression of Galectin-3-mediated TLR4 signaling pathway
... Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and gly- colipids, and ...
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Curcumin attenuates MSU crystal induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
... that TLR4 mediated the initial steps of gout pathogenesis and that TLR4 expression was pivotal to MSU crystal-induced inflammation ...of TLR4. In the TLR4 signaling pathway, ...
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The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection
... of TLR4. To ascertain whether the TLR4 signaling pathway was required for LPS-mediated pro- tection against influenza virus-induced lethality, we next exam- ined the replication kinetics of a ...
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Investigation of TLR4 Gene Expression in Prostate Tumor Tissues
... mean TLR4 staining score was significantly higher in BPH tissues with inflammation compared with BPH tissues without inflammation ...LPS/TLR4 signaling induces down-regulation of the bone morphogenic ...
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Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
... that TLR4 expression increased markedly in microglial cells, indicating its involvement in ICH-induced ...of TLR4 in neurons and astro- cytes in perihematoma tissue, suggesting TLR4 in neu- rons and ...
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Original Article LPS induces activation of the TLR4 pathway in fibroblasts and promotes skin scar formation through collagen I and TGF-β in skin lesions
... activate TLR4 signaling, leading to the overexpression of collagen I and TGF-β and the induction of hypertrophic scar forma- ...the TLR4 signaling pathway in 3T3-L1 cells in vitro and ...
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Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy
... the TLR4 positive breast cancer MDA-MB-231 cell line in inflammatory microenvironment by activation of apoptosis, autophagy and inhibition of TLR4 signaling ...and TLR4 signaling ...
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CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients
... of TLR4 in CD163+ macrophages was obviously increased ...the TLR4 signaling pathway is important for PA-MSHA induced re-education of CD163+ macrophages, CD163+ macrophages were treated with ...
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Original Article Protective effects of mesenchymal stem cells on acute liver injury via TLR4/NF-kB signaling pathway in sepsis mice
... the TLR4 signaling pathway ...that TLR4 was critically involved in the pathogenesis of sepsis-induced liver damage, and there was increasing evi- dence shown that sepsis-induced liver injury ...
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Contribution of TLR4 signaling in intermittent hypoxia mediated atherosclerosis progression
... respectively. TLR4, NF-κB p65 (nuclear factor κappa B p65), α-SMA (α-smooth muscle actin), MOMA-2 (mac- rophages/monocytes) expression in aortic root were detected by immunohistochemical ...
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Identification of key pathways and genes in <em>TP53 </em>mutation acute myeloid leukemia: evidence from bioinformatics analysis
... PI3K-Akt pathway, which are associated with a drug resistance mechanism, may be the potential mechanism of drug resistance in TP53 mutation AML and will provide new targets and strategies for indi- vidualized ...
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Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach
... Wnt signaling pathway was very important dur- ing the development of ...Wnt signaling pathway of ESCC were list- ed in the KEGG diagram with pathway ID ko04310 (Figure ...Wnt ...
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Impacts of Mild Hypothermia on LPS Mediated TLR4/NF κB Signaling Pathway in Microglia
... expressed TLR4. TLR4 belongs to the Toll-like receptor family, after stimulated by LPS, it could activate a variety of signaling pathways, and would eventually be activated by the hydrolysis of NF-κB ...
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M2 polarized tumor associated macrophages facilitated migration and epithelial mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway
... 3 TLR4 played a crucial role in the M2-CM-induced increase in the malignant properties of HCC ...upregulated TLR4 expression in HCC cells. TLR4 expression in HCC cells was detected using western ...
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Identification of key gene pathways and coexpression networks of islets in human type 2 diabetes
... and signaling pathway enrichment were conducted using the online tool of KEGG pathway (Figure ...MAPK signaling pathway, PI3K–Akt signaling pathway, and Ras ...
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Identification of COX5B as a novel biomarker in high-grade glioma patients
... KEGG pathway is a collection of manually drawn pathway maps representing our knowledge of the molecular interaction and reaction network for cellular processes, human diseases, and so ...
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