TNF alpha
Diabetes, an inflammatory process: Oxidative Stress and TNF alpha involved in hepatic complication
... in TNF-α due to an increased expression of iNOS, which led to a high production of NO ...blocks TNF-α, leads to a decrease in the expression of iNOS, which is increased in the diabetic ...of TNF-α ...
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Bilateral muscle fiber and nerve influences by TNF alpha in response to unilateral muscle overuse – studies on TNF receptor expressions
... the TNF recep- tors in nerve ...for TNF- alpha and its receptors have been very seldom noted for nerves in previous studies on various organs, expressions for TNF-alpha, TNFR1 and TNFR2 ...
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Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF alpha receptor subtype 1 and require TNF alpha receptor subtype 2
... prothrombotic TNF a effects, including an enhanced endothelial production of reactive oxygen species; upregulation of p-selectin, tissue factor, and PAI-1 expression; and suppression of throm- ...bomodulin. ...
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Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids TNF alpha priming increases glucocorticoid inhibition of TNF alpha induced cytotoxicity/apoptosis
... of TNF-a in mice (54–56), and the same dose of anti– TNF-a that blocks its lethality in normal mice is ineffective in adrenalectomized animals ...of TNF-a but become tolerant ...by TNF-a, of ...
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Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes
... when TNF alpha was added in the preconfluent stages of cell ...by TNF alpha of differentiation of keratinocytes as indicated by the stimulation of cornified ...
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Obesity and diabetes in TNF alpha receptor deficient mice
... models. TNF elicits cellular responses via two receptors called p55 and ...of TNF in glucose homeostasis using mice lacking one or both TNF ...that TNF, acting via its receptors, is ...
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Sulforaphane has opposing effects on TNF alpha stimulated and unstimulated synoviocytes
... Methods: Cultured synoviocytes were stimulated with sulforaphane (SFN) with or without TNF- a pre-treatment. NF- B, AP-1, and Nrf2 activation was investigated via dual luciferase reporter gene assays. Matrix ...
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The expression of TNF alpha by human muscle Relationship to insulin resistance
... link TNF expression with whole body insu- lin action, we examined the expression of TNF by muscle, which is responsible for the majority of glucose uptake in ...RT-PCR, TNF was detected in human ...
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Endotoxin induction of tumor necrosis factor is enhanced by acid labile interferon alpha in acquired immunodeficiency syndrome
... of TNF in vitro. TNF production by BM from patients with HIV infections and normal controls was measured by a cytotoxicity assay on L929 cells using human TNF alpha as a ...of TNF and ...
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OX40 Stimulation by gp34/OX40 Ligand Enhances Productive Human Immunodeficiency Virus Type 1 Infection
... OX40 is a member of the tumor necrosis factor (TNF) receptor superfamily and known to be an important costimulatory molecule expressed on activated T cells. To investigate the role of costimulation of OX40 in ...
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Dual effect of pre ischemic administration of TNF alpha on myocardial infarct size
... ble TNF receptor, some studies observed a significant reduction of infarct size [16] whereas others detected no significant effects ...of TNF p75 receptor induces a loss in cardio- protection, suggesting a ...
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Functional switching of macrophage responses to tumor necrosis factor alpha (TNF alpha) by interferons Implications for the pleiotropic activities of TNF alpha
... of TNF alpha in stimulating the synthesis of two macrophage gene products, namely IGF-1, a growth factor implicated in wound repair and fibrosis, and complement component factor B (Bf), an alternative ...
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The Association of Psychological Stress Related Cytokines (TNF Alpha, IFN Gamma) with Essential Hypertension in Ningxia Hui Autonomous Region
... serum TNF alpha levels of hypertension group were higher than the control group (ρ < ...serum TNF alpha level of the Hui hypertension group was higher than the Han hypertension group (ρ ...
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Unleashing endogenous TNF alpha as a cancer immunotherapeutic
... The history of TNF-alpha is very closely related to the history of tumor immunotherapy. In the early 1900s, the New York physician William Coley observed that various cancer patients would enter remission ...
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An Intensive Mind and Body Therapeutic Program Leads to Alteration in Gene Expression Critical to Aging Process in Peripheral Blood Stem Cells
... pro-inflammatory TNF al- pha/NF-kB; 2) IL-12 signaling pathway; 3) hypoxic HIF-1-alpha; 4) key regulator of programmed cell death, C-MYC; and 5) P38 MAPK (mitogen-activated protein kinase) signaling ...
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CC and CXC chemokine levels in children with meningococcal sepsis accurately predict mortality and disease severity
... MIP-1α and GRO-α were moderately elevated or even unde- tectable in moderately ill patients, but reached very high levels in the severely ill patients. MCP-1 and IL-8 serum levels were detectable in all patients and ...
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Roles of Tumor Necrosis Factor Alpha (TNF-α) and the p55 TNF Receptor in CD1d Induction and Coxsackievirus B3-Induced Myocarditis
... mouse results in substantial myocarditis susceptibility. The in- creased disease susceptibility is not apparently due to increas- ing cardiac virus titers, since mice given all three virus doses showed equivalent virus ...
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Imaging in rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and osteoarthritis: An international viewpoint on the current knowledge and future research priorities
... of TNF in the short-term (78-80), but with the time-aver- aged disease activity leading to more struc- tural damage in the spine over time, particu- larly in males (81) in both the short- and the long-term ...
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The Effect of Chloroquine on Pro Inflammatory Cytokines Levels in Graves’ Disease: Historical Cohort from a Pilot Randomized Controlled Trial
... Interleukin-1 alpha (IL-1α), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6) and Interferon gamma ...and TNF-α in serum of patients with Graves’ hyperthyroid- ism in contrast to ...
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The effect of the pro inflammatory cytokine tumor necrosis factor alpha on human joint capsule myofibroblasts
... the stable prostacyclin metabolite 6-keto-PGF 1A were deter- mined using GC/MS with minor modifications of a previ- ously described method [24]. Briefly, cell culture supernatants were spiked with approximately 10 ng of ...
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