TNF-R
Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2
... labelled TNF receptosomes To isolate TNF plasma membrane receptors after ligand binding and internalization biotinylated TNF (Fluorok- ine-Kit, R&D Systems, Wiesbaden, Germany) and magnet- ...
15
Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses
... p60 TNF receptor (TNFR1, p55) and the p80 TNF receptor (TNFR2, p75) ...the TNF pathway clearly, TNFα-related proteins were extracted from the whole network, and the TNFα-related pathway is shown in ...
19
TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future
... membrane TNF with high affinity and specificity, and they all prevent TNF from binding to TNFRs (see ...as TNF/ TNFR-induced IL-6 – a potent mediator of TNF-induced inflamma- tion ...membrane ...
20
Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia
... Cerebral ischemia induces a rapid and dramatic up-reg- ulation of tumor necrosis factor (TNF) protein and mRNA, but the cellular sources of TNF in the ischemic brain have not been define[r] ...
17
On the binding of tumor necrosis factor (TNF) to heparin and the release in vivo of the TNF binding protein I by heparin
... The TNF-binding protein I (TNF-BP-I) is a soluble fragment of the p60 transmembrane TNF receptor and an antagonist to ...serum TNF-BP-I was found to be increased in patients with ...
7
Tumour necrosis factor allele variants and their association with the occurrence and severity of malaria in African children: a longitudinal study
... regulating TNF responses may actually be located downstream of the TNF gene and that TNF allele variants considered are in linkage dise- quilibrium with the causal variant in some populations, but ...
11
OX40 Stimulation by gp34/OX40 Ligand Enhances Productive Human Immunodeficiency Virus Type 1 Infection
... OX40 is a member of the tumor necrosis factor (TNF) receptor superfamily and known to be an important costimulatory molecule expressed on activated T cells. To investigate the role of costimulation of OX40 in ...
10
Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood stage antigens in Burkina Faso
... studies, TNF polymorphisms have been related to severe ...of TNF gene exhibit differential associations to malaria and TNF production in different populations suggesting that individual TNF ...
8
Antithrombotic activity of TNF α
... by TNF-a in thrombus formation and growth in an in vivo mouse ...of TNF-a at doses found in sepsis transiently inhibits thrombus formation and delays arterial occlusion upon vascular ...the ...
9
Inhibiting TNF-α signaling does not attenuate induction of endotoxin tolerance
... exogenous TNF- α stimulation can induce the production of endogenous TNF- α and generate a tolerant-like state upon subsequent ...of TNF- α signaling and an autocrine amplification loop in endotoxin ...
9
Lack of Tumor Necrosis Factor Alpha Induces Impaired Proliferation of Hepatitis B Virus-Specific Cytotoxic T Lymphocytes
... and TNF-␣. As it has been reported that both IFN-␥ and TNF-␣ released from HBV-specific CTLs can abolish HBV replication in hepatocytes in HBV transgenic mice (2, 3, 10, 17) and deliver noncytopathic ...
8
Effect of Tumor Necrosis Factor on Body Systems
... of TNF. The binding of TNF-α activates it in most human ...as TNF receptor superfamily member 1B ...both TNF- α and ...the TNF homotrimer. Approximately 500-10000 high-affinity ...
15
Does protein kinase R mediate TNF α and ceramide induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?
... (TNF-α). TNF-α is capable of inducing cartilage catabolism in vitro [5] via increased MMP expression and activation [4] and is elevated in the synovial fluids from 2-AP = 2-aminopurine; DMEM = Dulbecco’s ...
10
iRhom2 promotes lupus nephritis through TNF α and EGFR signaling
... as TNF-α and heparin-binding EGF (HB-EGF), have been implicated in the pathogenesis of chronic kidney ...and TNF-α signaling in the kidney ...that TNF-α and HB- EGF/EGFR signaling pathways are highly ...
17
TNF-α inhibitors: are they carcinogenic?
... Lymphoma has been reported after TNF- α receptor use. Braun et al reported 26 cases of lymphoma after treatment with etan- ercept (18 cases) and infliximab (8 cases) in patients being treated for RA and Crohn’s ...
7
Effective use of TNF antagonists
... Discontinuation rates for anti-TNF agents as observed in two long-term, randomized RA trials, one involving inflix- imab (ATTRACT) and the other etanercept (ERA), are listed in Table 3 [12,14]. These trials ...
7
TNF α in AMI
... New Zealand white rabbits were anesthetized and a silk suture was tied around the Left Anterior Descending Artery (LAD) and occluded for 1.5 h. Thirty rabbits were used in four different groups. Group I underwent surgery ...
5
A new venue of TNF targeting
... disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Uncoupling the proinflammatory from the immunosuppressive properties [r] ...
59
CCL 11, TNF
... systemic TNF-α may cause acute cognitive dysfunctions [69], while increased levels of peripheral blood CCL-11 may rapidly pass the BBB and induce attenuated hippocampal neurogegensis thereby inducing memory ...
59
TNF Type I Receptor Inhibitor, R 7050 Attenuates Acute Kidney Injury in a Mouse Model of Crush Syndrome
... as TNF- α and IL-6, play a critical role for induction of AKI during CS ...that TNF type-I receptor (TNFR1) inhibitor, R-7050 significantly attenuates the onset of AKI after the muscular ...process, ...
12