TNF receptor
Tumor necrosis factor receptor I blockade shows that TNF dependent and independent mechanisms synergise in TNF receptor associated periodic syndrome
... TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease involving mutations localised to the ectodomain of the p55 TNF receptor, TNFR1 ...causing ...
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A pro inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor associated periodic syndrome (TRAPS)
... encoding TNF receptor 1 (TNFR1) cause the autosomal domi- nant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory ...
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Falling into TRAPS – receptor misfolding in the TNF receptor 1 associated periodic fever syndrome
... periodic fever syndromes that are inherited in a recessive manner, such as familial Mediterranean fever (FMF) caused by mutations in the gene encoding the neutrophil-specific protein Pyrin [2]. Most evidence currently ...
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The role of TNF receptor family members and other TRAF dependent receptors in bone resorption
... There are at least six distinct TRAF forms, not all of which induce intracellular signaling. TRAF2, 5, and 6 have been shown to be involved in TNFR and TIR downstream activa- tion of NF- κ B and the c-jun amino-terminal ...
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Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2
... endogenous TNF is similar to the TNF produced by mac- rophages upon LPS stimulation ...endogenous TNF and intracellularly localized hicp75TNFR was ...endogenous TNF in the TGN is difficult to ...
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Renal cell–expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis
... To gain insights into the cell types contributing to the phenotype in TNFR1-deficient mice, we evaluated the expression pattern of TNFR1 on circulating, splenic, and renal accu- mulated leukocytes in nephritic wild-type ...
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Relative Sensitivity of Hepatitis B Virus and Other Hepatotropic Viruses to the Antiviral Effects of Cytokines
... the TNF ␣ receptor (TNF ␣ RKO), or the IFN ␣ /  receptor (IFN ␣ /  RKO) in order to determine the relative contribution of each cytokine to the antiviral effects observed in each of these ...
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Age-Dependent Levels of Select Immunological Mediators in Sera of Healthy Children
... Interleukin-1 receptor antagonist (IL-1RA), soluble IL-2R (sIL-2R) (sCD25), IL-6, IL-8, tumor necrosis factor alpha (TNF-a), soluble TNF receptor type II (sTNF-RII) (sCD120b), gamma interferon ...
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Thiazolidinediones block tumor necrosis factor alpha induced inhibition of insulin signaling
... that TNF- a plays a large role in the development of insulin resistance observed linked to obesity, and perhaps to other disorders ...Indeed, TNF- a mRNA is overexpressed in the adipose tissue of most ...
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The association between hearing impairment and polymorphisms of genes encoding inflammatory mediators in Japanese aged population
... responses. TNF-α does not work inde- pendently at the cellular ...receptors, TNF receptor superfamily member 1A (TNFRSF1A/ also known as p55 andTNFR1) and member 1B (TNFRSF1B/ also known as p75 and ...
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The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation
... direct TNF actions comes from electrophysiological studies showing that low-dose subcuta- neous injections of TNF- α induce ectopic activity in nocicep- tive neurons within 2 minutes, with higher doses ...
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Taubitz, Anela (2012): TNF-Rezeptor 1- und 2-spezifische Entzündungsreaktionen im Glomerulus. Dissertation, LMU München: Medizinische Fakultät
... To identify TNF-receptor 1 Tnfr1- and 2 Tnfr2-mediated inflammatory pathways in glomeruli expression and function of both TNF receptors were investigated in murine kidneys, in isolated g[r] ...
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IMMUNOMODULATORY EFFECTS OF DIESEL EXHAUST PARTICLES
... Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. A reevaluation of the literature regarding the health assessment of diesel engine e[r] ...
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Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus
... and TNF-receptor 1 (TNF-R1)-mediated apoptosis in the clearance of virally infected cells and in the regulation of the immune response was analyzed after murine cytomegalovirus (MCMV) infection of ...
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The tumor promoting actions of TNF α involve TNFR1 and IL 17 in ovarian cancer in mice and humans
... cytokine TNF-α is an important component of this interplay, but its effects are pleiotropic and therefore remain to be completely ...either TNF receptor 1 (TNFR1) signaling was manipulated in ...
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Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF alpha receptor subtype 1 and require TNF alpha receptor subtype 2
... (TNF) receptor subtypes to prothrombotic effects in endothelial cells in vitro ...(a) TNF a (5 ng/mL, 4 hours)-induced upregulation of P-selectin is significantly reduced after TNFR2 ...Whereas ...
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Anticytokine Therapy: The Newer Horizons Revisited
... membranous-bound TNF-receptor (mTNF-R). There are type I TNF-R (55 kDa molecular weight) and type II TNF-R (75 kDa molecular weight) and differ with each other in their intracellular domain, ...
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Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... Human TNF-α kit, for Fas— Quantikine ELISA Human Fas/TNFRSF6 kit, for Fas Ligand (FasL)—Quantikine ELISA Human Fas Ligand/ TNFSF6 kit, for soluble TNF receptor I (sTNF RI)— Quantikine ELISA Human ...
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Obesity and diabetes in TNF alpha receptor deficient mice
... that TNF- a plays a key role in mediating insulin resistance as a result of obesity ...adipose TNF production, as compared with tissues from lean individuals. TNF levels can be reduced with weight ...
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Inhibiting TNF-α signaling does not attenuate induction of endotoxin tolerance
... exogenous TNF- α stimulation can induce the production of endogenous TNF- α and generate a tolerant-like state upon subsequent ...of TNF- α signaling and an autocrine amplification loop in endotoxin ...
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