TNF receptors
TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future
... membrane TNF is a possible identifier of anti-TNF therapeutic responders ...membrane TNF-positive mucosal immune cells strongly correlate with mucosal healing and ADA treatment efficacy ...membrane ...
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The role of the TNF receptors and apoptosis inducing ligands in tumor growth
... Howe ver, ANT2 knockdown also up-regulated DR4 and DR5 in the p53-mutant cell lines BT474 and T47 D [42]. Treatment of the cells with a demethylation agent or JNK inhibitor prevented the ANT2 shRNA- induced ...
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Shedding kinetics of soluble tumor necrosis factor (TNF) receptors after systemic TNF leaking during isolated limb perfusion Relevance to the pathophysiology of septic shock
... and TNF at 8–12 h (Fig. 5 b) and the further reduction in serum TNF concentrations ...and TNF could not be re- versed by its late, endogenous correction, and were actually predetermined by the ...
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Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia
... Cerebral ischemia induces a rapid and dramatic up-reg- ulation of tumor necrosis factor (TNF) protein and mRNA, but the cellular sources of TNF in the ischemic brain have not been define[r] ...
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Taubitz, Anela (2012): TNF-Rezeptor 1- und 2-spezifische Entzündungsreaktionen im Glomerulus. Dissertation, LMU München: Medizinische Fakultät
... To identify TNF-receptor 1 Tnfr1- and 2 Tnfr2-mediated inflammatory pathways in glomeruli expression and function of both TNF receptors were investigated in murine kidneys, in isolated g[r] ...
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s-2004-822303.pdf
... either TNF receptors or IL1R1 is not independently essential to these innate immune responses when examined using mutant ...However, TNF-a and IL-1 induce overlapping signal- ing pathways and the ...
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Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice
... different TNF receptors (TNFRs) in pulmonary emphysema has not been ...emphysema. TNF-α transgenic mice, a murine model of COPD in which the mice spontaneously develop emphysema with a large increase ...
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Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
... Through screening a series of PGRN deletion mutants retaining TNFR binding ability, we have generated an engineered protein which appears to be the minimal molecule of PGRN that still has TNFR binding affinity [6]. This ...
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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
... and TNF are expressed in IVD and upregulated with degeneration, degen- erate IVDs show a much greater expression level of IL-1β than TNF-α and that, while the IL-1R1 was upregulated in degener- ation, the ...
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Preclinical and clinical aspects of TNF-α and its receptors TNFR1 and TNFR2 in breast cancer
... the TNF receptor superfamily with 29 mem- bers found in humans ...two TNF receptors have similar extracellular domains consisting of multiple cysteine-rich repeats of approximately 40 amino acids in ...
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The Role of Neurotransmitters in Anesthesia
... Metabotropic Receptors: Four metabotropic histamine receptor types are ...brain receptors are postsynaptic excitability and plasticity that lead to behavioral state like cognition, emotion, learning, memory ...
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Advances in the genetics of endometriosis
... Polymorphisms in cytokine genes, including tumor necrosis factor (TNF)α, interleukin (IL)-1β, IL-6 and IL-10, and their receptors (IL-1RN and IL-2Rβ), have been extensive[r] ...
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Skin Targeting Approaches in Cosmetics
... barriers. Receptors like Epidermal Growth Factor Receptor (EGFr), interleukin-1 receptor (IL- 1r), Tumor Necrosis Factor Receptor (TNF), Plate- let-Derived Growth Factor Receptor (PDGFr) and ...
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β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations
... by TNF-α/clenbuterol co-treatment play a role in leukocyte ...after TNF-α and/or clenbuterol ...and TNF-α/clenbuterol co-treatment can be ...2), TNF-α/ clenbuterol co-administration led to a ...
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The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat
... [7]. TNF-a has been sug- gested to stimulate angiogenesis following ischemia through induced expression of angiogenesis-related genes ...[10]. TNF- a effects are mediated via two receptors, ...
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The current status of targeting BAFF/BLyS for autoimmune diseases
... It is increasingly recognized that B cells have multiple functions that contribute to the pathogenesis of autoimmunity. Specific targeting of B cells might therefore be an appropriate therapeutic intervention. The tumor ...
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The production of cytokine-like molecules IL-6, TNF-α and leptin and their soluble receptors, from an abdominal adipose tissue bed
... and has been seen to accumulate in damaged endothelial walls (Okamoto et al, 2000). It is part of the family of soluble defence collagens which have been shown to inhibit myelomonocytic cell lineage and suppress ...
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Inhibition of TRAIL-Induced Apoptosis and Forced Internalization of TRAIL Receptor 1 by Adenovirus Proteins
... two receptors, TRAIL-R1 (also known as death receptor 4) and TRAIL-R2 (also known as death receptor 5), that are members of the TNF receptor superfamily of death domain-containing ...of receptors ...
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Alveolar epithelial and endothelial cell apoptosis in emphysema: What we know and what we need to know
... like TNF, and oxidative stress (cell injuries) can also modulate elements involved in alveolar cell sensitivity to TRAIL-mediated apoptosis (TRAIL receptors, p53, and Bax levels) [12] and switch alveolar ...
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IL-1β induces murine airway 5-HT2A receptor hyperresponsiveness via a non-transcriptional MAPK-dependent mechanism
... In order to ascertain if epithelium is involved in the up- regulation of 5-HT-induced contraction, the epithelium was removed after the trachea had been cultured for 4 days in the absence and presence of IL-1β (10 ...
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