(TNF) tumor necrosis factor
Distinct Pathways for Tumor Necrosis Factor Alpha and Ceramides in Human Cytomegalovirus Infection
... Human cytomegalovirus (HCMV) infection can be fatal to immunocompromised individuals. We have previously reported that gamma interferon and tumor necrosis factor alpha (TNF- a ) synergistically ...
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CrmE, a Novel Soluble Tumor Necrosis Factor Receptor Encoded by Poxviruses
... Cytokines and chemokines play a critical role in both the innate and acquired immune responses and constitute prime targets for pathogen sabotage. Molecular mimicry of cytokines and cytokine receptors is a mechanism ...
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Effect of Tumor Necrosis Factor on Body Systems
... Tumor necrosis factor-alpha (TNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase ...
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Tumor necrosis factor expression in human epithelial tumor cell lines
... Tumor necrosis factor (TNF) is a monokine with in vitro cytotoxicity for some but not all tumor ...epithelial tumor cell ...14 tumor cell lines has detectable levels of high ...
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Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis
... Tumor necrosis factor (TNF)–␣is a proinflammatory cytokine that mediates inflammation in response to various pathogens, including Mycobacterium tuberculosis, but is also a key factor in the ...
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Contribution of tumor necrosis factor alpha to the pathogenesis of stroke
... TNF-alpha stimulates release of three best- known beta chemokines — which can play a signif- icant role in inflammatory processes within the brain — i.e. macrophage inflammatory protein-1 alpha (MIP-1 alpha), macrophage ...
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The tumor necrosis factor receptor and human neutrophil function Deactivation and cross deactivation of tumor necrosis factor induced neutrophil responses by receptor down regulation
... Despite numerous reports, the role of tumor necrosis factor (TNF) in polymorphonuclear leukocyte (PMN) function remains controversial. We found TNF to be a potent, pertussis toxin-independent ...
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Tumor necrosis factor-α serum levels in healthy smokers and nonsmokers
... risk factor for chronic obstructive pulmo- nary disease (COPD) ...induce tumor necrosis factor-a (TNF-a) production by alveolar macrophages, which in turn may enhance the production of ...
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Tumor Necrosis Factor and Regulatory T Cells
... cells involved in the maintenance of immune homeostasis, and their dysregulation is involved in various autoimmune and inflammatory diseases. In many inflammatory diseases, tumor necrosis factor ...
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The role of tumor necrosis factor alpha in systemic lupus erythematosus
... (a) tumor necrosis factor (TNF) expression was low and TNF administration helpful or (b) TNF was high and TNF blockade of therapeutic benefit, depen- ding on the mouse model ...
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Cachectin/Tumor Necrosis Factor
... synthesized tumor necrosis factor, agonist peptide TNF (70-80) and demonstrated that it enhanced the human PMN-mediated killing of plasmodium falciparum in vitro and reduced the plasmodium chabaudi ...
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The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia
... Tumor necrosis factor (TNF) is a protein hormone implicated in the development of septic shock and other pathologic states. However, complexities inherent in detecting TNF synthesis by individual ...
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Systemic use of tumor necrosis factor alpha as an anticancer agent
... 1). Tumor necrosis factor receptor 1 (TNFR1), which preferentially binds soluble TNF-α and is found almost ubiquitously on the surface of cells, and ...2). Tumor necrosis factor ...
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Emerging role of anti tumor necrosis factor therapy in rheumatic diseases
... Tumor necrosis factor alpha (TNF- α ) is an inflammatory cytokine that has been implicated in a variety of rheumatic and inflammatory diseases. New understanding of the importance of TNF-α in the ...
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TUMOR NECROSIS FACTOR ALPHA AND INTERLEUKIN 6 IN ESSENTIAL HYPERTENSION
... of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) which might play an important role in the initiation and progression of hypertension by a variety of mechanisms such as giving rise to ...
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Expression of recombinant feline tumor necrosis factor is toxic to Escherichia coli.
... The tumor necrosis factor (TNF) genes from cats, horses, and pigs have all been cloned into the pFLAG-1 fusion protein expression vector (International Biotechnologies, ...
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Effects of Tumor Necrosis Factor Alpha on Sin Nombre Virus Infection In Vitro
... of tumor necrosis factor alpha (TNF-␣) in plasma during the acute phase of hantavirus infection was reported (19, ...of tumor necrosis in mice ...
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Dissociation of interferon-gamma production and resistance to leishmaniasis in the absence of tumor necrosis factor
... The delineation of T helper 1(Th1) and T helper 2 (Th2) responses in promoting resistance and susceptibility to experimental cutaneous leishmaniasis has provided a substantial contribution to the understanding of the ...
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Cellular Responses to Tumor Necrosis Factor
... Tumor necrosis factor α (TNF) is a proinflammatory cytokine produced mainly by activated macrophages or monocytes and plays an important role in diverse cellular events, such as the production of ...
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Tumor necrosis factor alpha inhibits expression of pulmonary surfactant protein
... Tumor necrosis factor-alpha (TNF-alpha) decreased the expression of pulmonary surfactant proteins SP-A and SP-B in human pulmonary adenocarcinoma cell ...
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