TNFAIP3/A20
Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal dominant Behçet's disease
... expressing A20 C243Y as com- pared with WT ( fi gure ...exogenous A20 pro- vided compared with that of endogenous A20, which pre- sents normally in THP-1 ...WT A20 and C243Y A20 is equal ...
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Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet’s disease
... loss-of-function TNFAIP3 variants identified in BD-like patients are now classified as haploinsufficiency of A20 (HA20) ...heterozygous TNFAIP3 variant and a copy number variation found in two ...
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TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
... and TNFAIP3 gene rs10499194 or rs13207033 polymorphism, (2) studied on human beings, (3) study provided sufficient data to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), and P value, and (4) ...
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Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population
... in TNFAIP3, rs7708392 in TNIP1, and rs4937333 and rs6590330 in ETS1 showed significant associations with SLE (Table 1; see also Table S1 in Additional file ...in TNFAIP3 is a nonsynonymous variant, and the ...
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A20 deficiency causes spontaneous neuroinflammation in mice
... AD: Alzheimer ’ s disease; ANOVA: analysis of variance; BBB: blood brain barrier; CCL-2: chemokine (C-C motif) ligand 2; CNS: central nervous system; CX: cerebral cortex; DAB: 3,3 ’ -diaminobenzidine tetrahydrochloride; ...
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Expression of Tumor Necrosis Factor Alpha-Induced Protein 3 mRNA in Peripheral Blood Mononuclear Cells Negatively Correlates with Disease Severity in Psoriasis Vulgaris
... (11). The PASI was evaluated for all patients by the same physician, who was blinded to the A20 mRNA results. The patients were divided into a mild group and a severe group based on the mean PASI score. A patient ...
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An Autoimmune Disease Associated Risk Variant in the TNFAIP3 Gene Plays a Protective Role in Brucellosis That Is Mediated by the NF κB Signaling Pathway
... (28). TNFAIP3 encodes A20, a ubiquitin-editing enzyme with a pivotal role in negatively regulating NF- B signaling downstream of multiple cell surface receptors ...(35). A20-deficient cells excrete ...
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The genetic landscape of dural marginal zone lymphomas
... as A20) is a negative regulator of NF-κB signaling [14, ...of TNFAIP3 in mice results in mislocalization of marginal zone B-cells and defective antigen-induced B-cell maturation ...[16]. ...
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Association of the tandem polymorphisms (rs148314165, rs200820567) in TNFAIP3 with chronic hepatitis B virus infection in Chinese Han population
... [11]. A20 mRNA expression in peripheral blood mono- nuclear cells was shown to be associated with progression of chronic HBV infection [12], and increased A20 expres- sion on monocytes was shown to be ...
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Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case control association study
... of TNFAIP3 is observed both in SLE and RA genetics, TNIP1 appears to play a major role in SLE, but not in ...in TNFAIP3 deficient cells, indicating that TNIP1 does not always require A20 to perform ...
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A20 deubiquitinase controls PGC-1α expression in the adipose tissue
... detect A20 (TNFAIP3), PGC-1α and PPARγ in the brown, visceral and subcutane- ous adipose tissue (Mm00437121_m1; Mm44718 3 m1; Mm01184322_m1, respectively - Life Technologies, Van Allen Way Carlsbad, CA, ...
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A20 suppresses canonical Smad dependent fibroblast activation: novel function for an endogenous inflammatory modulator
... of A20 is associated with premature mortality due to spon- taneous multi-organ inflammation [11], while partial loss in haplo-insufficient mice is associated with impaired tissue regeneration and spontaneous ...
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Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia
... in A20 (tumor ne- crosis factor-α-induced protein 3; TNFAIP3), which is a nuclear factor kappa B (NF-κB) negative regulator, gen- etic alterations are frequently found in lymphomas, sug- gesting that there ...
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A20 Modulates Lipid Metabolism and Energy Production to Promote Liver Regeneration
... protein A20/tnfaip3 [19] as a critical cytoprotective gene in the ...liver. A20 is induced in hepatocytes in response to inflammatory insults or injury, including liver resection, as part of a ...
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SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren’s syndrome
... The polymorphisms of IL10 (rs1800896), TNFα (rs1800629) and TNFAIP3 (rs2230926) were detected using an allele-specific polymerase chain reaction (PCR) assay. DNA was isolated from venous blood, and purified in the ...
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MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis
... transfection of miR-19b-3p mimic, we obtained similar results after 6 Gy radiation stimulation, as measured by Western blot (Fig. 8). Specifically, p65 level was de- creased, and p-p65 level was increased in transfected ...
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Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells
... Then we determined whether silencing of A20 combined with IFN- γ could affect the process of apoptosis by using an Annexin V-FITC/PI staining assay. After treatment with 100 ng/mL IFN- γ for 24 h, sh-A20 ...
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APPLICATION OF BIOGAS IN I.C ENGINE: A REVIEW
... Awogbemi et. Al. [2] Research is on the development and testing of a biogas-petrol blend to run a spark ignition engine. A20:80 ratio biogas: petrol blend was developed as an alternative fuel for spark ignition ...
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Evaluation of the rheumatoid arthritis susceptibility loci HLA DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort
... In subsequent analyses, trend tests were performed across all three genotypes; the ORs (95% confidence intervals) shown are per copy of the HLA-DRB1 SE or per copy of the minor allele for the remaining loci (Table 2). ...
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<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>
... TNFAIP1, TNFAIP3, TNFAIP5, TNFAIP6, TNFAIP8 and TNFAIP9, which can be directly involved in activating TNFAIP1, TNFAIP5, TNFAIP8 and ...and TNFAIP3 inducing tumors may be related to NF- κ B signaling ...
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