tolerogenic dendritic cells
Tolerogenic Dendritic Cells Induced by BD750 Ameliorate Proinflammatory T cell Responses and Experimental Autoimmune Encephalitis in Mice
... BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental ...
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NF-κB, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone- generated tolerogenic dendritic cells in the inflammatory environment
... Tolerogenic dendritic cells (tDCs) may offer an intervention therapy in autoimmune diseases or ...and tolerogenic function of tDCs after encountering inflammatory environment are prerequisite ...
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Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
... T cells (Treg) [5, 6], in contrast to treatment with unpulsed tolDC ...B cells (Breg), or natural killer cells (NK) in the spleen population between the different treatment groups could be detected ...
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Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients
... clinical signs of EAE was able to abrogate disease progression. However, the beneficial effect of the antigen-specific therapy was not stable and several ad- ministrations of cells were required [9]. The ...
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Generation, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells
... marrow cells with GM-CSF and IL-4, and then induced to tolDCs by additional culturing with an agent(s) known to confer tolerogenic ...Tr-1 cells from precursor T cells ...
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In vitro suppression of immune responses using monocyte derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome
... It has previously been reported that monocytes from pSS patients produced high levels of IL-6 and BAFF [16]. We were, therefore, interested to see if this would be car- ried over to the monocyte-derived DC from pSS ...
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A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines
... Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in antigen-specific immune responses and tolerance ...antigen-presenting cells to autoreactive T ...T ...
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Comparative study of clinical grade human tolerogenic dendritic cells
... T cells. Regulatory T cells suppress the responses of alloreactive or self-reactive CD4+ T cells and are supposed to maintain immunologic self-toler- ance or control autoimmunity ...T cells ...
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T cell killing by tolerogenic dendritic cells protects mice from allergy
... T cells, may be exploited therapeutically for depleting antigen-specific T cells and, thereby preventing allergic immune ...generate tolerogenic DCs in the laboratory have already met with some ...
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Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
... T cells. To investigate this, CD4 + T cells were isolated from an eGFP-FoxP3 knock-in mouse using separation beads and sorted for two populations of cells, CD4 + CD25 + FoxP3-GPF + or CD4 + CD25 − ...
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Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice
... Dendritic cells have been shown to regulate as well as elicit the immune response; those cells with regulatory properties are called tolerogenic dendritic ...erogenic dendritic ...
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Cestode Antigens Induce a Tolerogenic-Like Phenotype and Inhibit LPS Inflammatory Responses in Human Dendritic Cells
... modify Dendritic Cells (DCs) phenotypes and impair their functions in order to create a safer environment for their ...these cells by reducing the expression of the maturation markers and the ...
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Nicotine Protects Dendritic Cells from Apoptosis and Support DCs-dependent CD4+ T-cell Priming in vitro
... Murine dendritic cells in the absence (mBMDCs) or presence of nicotine (100 µg/ml, mImNicDCs) were incubated with FITC- dextran (250 µg/ml) or FITC-OVA (25 µg/ml) for 30 ...
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The Research of Treg Cells: Progress and Challenge
... target cells via direct interaction of receptor-ligand pairs on Tregs and target cells; delivery of suppressive factors via gap junctions including cyclic adenosine monophosphate (cAMP); direct cytolysis; ...
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Dengue Virus Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact Dependent Mechanism Involving Adhesion Molecules
... affect the levels of mouse platelets (Fig. 2B) or the overall hematocrit levels (data not shown). Hepatic damage, as assessed by serum alanine aminotransferase (ALT) levels, was significantly lower in NK-optimized humice ...
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Dendritic Cells: Immune Regulators in Periodontal Health and Disease
... in dendritic cell survival, lymph node formation and organogenesis, and critical dendritic cell / T-cell interactions 33 ....The dendritic cells have been thought to contribute indirectly to ...
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Expression of tolerogenic potential-representing markers on clinical-grade therapeutic dendritic cell-based cancer vaccines
... and tolerogenic properties-representing markers (CD85k [ILT3], CD273 [PD-L2], and CD274 [PD- L1]) at a single cell level in order to phenotypically evaluate the immunogenic versus the tolerogenic potential ...
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Antigen processing and T cell priming by mouse dendritic cells
... tissue dendritic cells present the processed antigen to T cells in lymphoid organs(Guery et al, ...B cells(Muraguchi et al, 1988), and activated B cells may also prime naive T ...
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Mechanisms Underlying the Induction of Regulatory T cells and Its Relevance in the Adaptive Immune Response in Parasitic Infections
... dendritic cells. The maturation of human monocyte-derived dendritic cells (DCs) in vitro with hemozoin and merozoites prevented IL-12 production and augmented the release of IL-10 and ...
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Knockdown of NEAT1 induces tolerogenic phenotype in dendritic cells by inhibiting activation of NLRP3 inflammasome
... FoxP3 cells (K) in hearts harvested from different ...T cells was assessed by flow cytometry in three different ...stimulator cells were C57BL/6 splenocytes treated with mitomycin ...
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