toll-like receptor 7
Toll-Like Receptor 7 Inhibits Early Acute Retroviral Infection through Rapid Lymphocyte Responses
... understood. Toll-like receptor 7 (TLR7) is required for promoting germinal center reactions and virus-specific neutralizing antibodies at later time points postinfection, but TLR7’s role in ...
10
An Intranasally Delivered Toll-Like Receptor 7 Agonist Elicits Robust Systemic and Mucosal Responses to Norwalk Virus-Like Particles
... imidazoquinoline-based Toll-like receptor 7 and/or 8 (TLR7/8) agonist, is being evaluated as an adjuvant in FDA-approved clinical vaccine ...
9
Toll-Like Receptor 7 (TLR-7) and TLR-9 Agonists Improve Hepatitis C Virus Replication and Infectivity Inhibition by Plasmacytoid Dendritic Cells
... ABSTRACT Plasmacytoid dendritic cells (pDCs) are innate immune cells with high antiviral activity triggered by Toll-like receptor 7 (TLR-7) and TLR-9 stimulation. More- over, they are ...
11
Single Nucleotide Polymorphisms of Toll Like Receptor 7 and Toll Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
... of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han ...
7
Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8
... RNA-specific adenosine deaminase (ADAR)-mediated adenosine-to-inosine (A-to-I) editing is a critical arm of the antiviral re- sponse. However, mechanistic insights into how A-to-I RNA editing affects viral infection are ...
12
Manipulation of the Toll-Like Receptor 7 Signaling Pathway by Epstein-Barr Virus
... signal provided by TLR signaling (56) is induced by EBV infection and contributes to the initial B-cell growth response. Contact between naive B cells and UV-inactivated EBV upregulated the expression of a number of ...
11
Loss of Toll like receptor 7 alters cytokine production and protects against experimental cerebral malaria
... Background: Malaria, caused by Plasmodium sp. parasites, is a leading cause of global morbidity and mortality. Cerebral malaria, characterized by neurological symptoms, is a life-threatening complication of malaria ...
8
Toll like receptor 7 regulates pancreatic carcinogenesis in mice and humans
... Pancreatic ductal adenocarcinoma is the fourth most common cause of cancer death in the United States and is lethal in more than 95% of cases (1). Unlike most adenocarcinomas, pancreatic cancer is overwhelmingly composed ...
13
Pfaller, Christian (2010): Subversion of Toll-like receptor 7/9 signaling by Measles Virus - V holds the key. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Measles virus (MV) is a haematotropic member of the Paramyxoviridae family (order Mononegavirales, genus Morbillivirus) and an important human pathogen. It induces a generalized transient immune suppression as well as a ...
147
The relative role of IRAK 2 in TLR signalling
... Koziczak-Holbro, M., et al., IRAK-4 kinase activity is required for interleukin-1 IL-1 receptor- and toll-like receptor 7-mediated signaling and gene expression.. Koziczak-Holbro, M., et[r] ...
285
Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
... TLR1 Toll-like receptor 1 TLR2 Toll-like receptor 2 TLR3 Toll-like receptor 3 TLR4 Toll-like receptor 4 TLR5 Toll-like ...
37
Signal transduction by the lipopolysaccharide receptor, Toll like receptor 4
... LPS receptor complex by initially binding LPS and then forming a ternary complex with CD14, thus en- abling LPS to be transferred to the LPS receptor complex composed of Toll-like ...
10
Toll Like Receptor 3/TRIF Dependent IL 12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells
... In murine-derived DCs infected with T4R, we previously found a much smaller effect on IL-12p70 secretion than in T4R- infected human DCs (35). Additionally, a redundancy of TLRs in vivo has also been found in mice in ...
10
MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling
... IL-10 is a prototypical anti-inflammatory cytokine which has been shown to affect IRAK4 and TRAF6 ubi- quitination as described earlier. Utilizing three miRNAs target prediction programs, miR-106a was identified as ...
17
Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts
... A widespread expression of various TLRs has been demonstrated in the human eye, including the retina, uvea, lacrimal gland and conjunctiva [5,6]. TLRs are also found in the human cornea, and have been implicated in ...
10
RIG-I-Like Receptor and Toll-Like Receptor Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in a Severe Fever with Thrombocytopenia Syndrome Virus Infection Mouse Model
... In vitro studies have shown that NSs protein, a nonstructural protein of SFTSV, strongly inhibits innate immunity by targeting TBK1, which activates IRF-3 and -7 (28–30). In contrast, our mouse study demonstrated ...
13
Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess
... Some recent studies have evaluated the potential role of genetic variations of genes in immune system in the risk of acute periodontitis (AP), [2, 5-6] external apical root resorption, [7] caries [8] and adult ...
9
Chemoproteomics reveals Toll-like receptor fatty acylation
... for 7 days in RPMI supple- mented with 10% FBS, 10 ug/mL gentamicin and 25 ng/ mL GMCSF, with media changes on days 3 and ...Fc receptor block (BD Biosciences, San Jose, California, United ...
13
The Toll Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge
... of 7- to 8-week-old C57BL/6J mice were infected with 1,000 PFU of mouse-adapted EBOV via intraperitoneal ...about 7 days (17) ...10 7 to 10 5 genome equivalents per ...
10
Toll like receptor polymorphisms in malaria endemic populations
... Toll-like receptors are innate immune receptors that bind to conserved structural motifs expressed by micro- bial pathogens. TLR2, TLR4, TLR9, and downstream sig- naling pathways of these proteins have ...
10