Topo-I
T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors
... topoisomerase I (topo I) was examined in 26 systemic sclerosis (SSc) patients with anti-topo I antibody, 10 SSc patients without anti- topo I antibody, and 21 healthy ...
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Diagnostic value of anti topoisomerase I antibodies in a large monocentric cohort
... anti-topo I antibodies as well as for the comparison with other ...anti-topo I antibodies in different studies might be caused by ethnic background [1,11] or by different classification ...
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Topoisomerase I Associates Specifically with Simian Virus 40 Large-T-Antigen Double Hexamer–Origin Complexes
... Eventually, topo I is needed to release the torsion created by the progressing replication ...time, topo- isomerase activity must be controlled according to the pace of the helicase to prevent too ...
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Design, synthesis, molecular docking and cytotoxicity evaluation of some novel 5-arylidene-3-(substituted phenyl)-2-(p-tolylamino)-4-imidazolones
... are topo I poisons that are currently used clinically for the systemic treatment of colorectal, ovarian, breast and non-small lung ...camptothecin topo I inhibitors with better pharmacokinetic ...
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<p>Mitochondrial Stress–Mediated Targeting of Quiescent Cancer Stem Cells in Oral Squamous Cell Carcinoma</p>
... (AZ). Topo-i is known to in fl ict damage to rapidly proliferating cells by intercalating in ...while Topo-i would target these proliferating ...with Topo-i and HDAC-i in ...
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Topoisomerase I sites cluster asymmetrically at the ends of the simian virus 40 core origin of replication.
... Topo I, bound either to T antigen or to a cellular protein in a replicative complex, is positioned in the core origin to take advantage of the clusters of Topo I sites in the AT segment [r] ...
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Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target
... Elevated Topo I levels and activity in breast CSC-like ...for Topo I protein in CSC-like (S) and non-CSC-like (NS) cells from BC1, BC2 and BC3 ...(B) Topo I mRNA levels were ...
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The HLA DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma)
... anti-topoisomerase I antibodies (anti-topo ...anti- topo I positive patients, compared with 44% of anti-topo I negative patients (P < ...anti-topo I positive ...
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High serum sCD163/sTWEAK ratio is associated with lower risk of digital ulcers but more severe skin disease in patients with systemic sclerosis
... anti-topo I: anti-topoisomerase antibodies; CCB: calcium channel blocker; DLCO: diffusion capacity of the lungs for carbon monoxide; DU: digital ulcers; dSSc: diffuse cutaneous systemic sclerosis; ELISA: ...
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Synthesis and Insilico Assessment of Novel Benzothiazole Series against Human DNA Topo Isomerase I
... Topoisomerase I such as DT10, TGP11, DG112, DA113, ASN352, Glu356, Lys374, Lys425 and the compound 6cvi shows interactions with DT10, TGP11, Glu 356, lys425, Arg ...potent topo I inhibitor and can be ...
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Key words
... between topo I and topo IIα expression and high nuclear accumula- tion of p53 protein in ovarian carcinomas indicates that the levels of both enzymes might be regulated by the overexpression of p53 ...
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Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts
... of topo I. Human topo I plays an important role in DNA metabolic processes, such as transcription and replication, in which it releases topological stress in DNA chains ...[9,10]. Topo ...
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Frequency of circulating topoisomerase I specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma
... of topo-I-specific T cells in SSc patients have yielded limited results due to relatively weak cellular responses to topo-I as well as poor specificity, as autoreactive T cells have been found ...
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... Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring alkylating antitumour antibiotics. They are a class of sequence-selective DNA binding agents obtained from the thermophilic actinomycete Streptomyces ...
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Investigation of gene amplification and expression in prostate cancer
... Histopathoh^gical reports w h ic h included clinical details were reviewed for all adenocarcinoma cases. We classified cases into four categories: BPH (n = 41); well-differentiated prostate carcinoma o f Gleason score 6 ...
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The aggregation of dihydrodipicolinate synthase
... The addition of the polyhistidine tags to DHDPS Q90L resulted in increased yield; pET M11 DHDPS Q90L yielded an average of 42.1 mg (121.9 units with a specific activity of 2.90 units/mg) per litre of culture and pET ...
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HESS Opinions "Topography driven conceptual modelling (FLEX Topo)"
... It is logical to base a classification system on the topog- raphy. With modern technology topographical signatures can be determined accurately. Until now, most approaches that make use of topography use characteristics ...
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Vaccinia Virus DNA Ligase Recruits Cellular Topoisomerase II to Sites of Viral Replication and Assembly
... of topo- isomerase II antigens changes in poxvirus-infected ...contained topo- isomerase II ...less topo- isomerase II was recruited to virosomes in cells infected with ⌬ L29 and VP41-8 viruses even ...
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DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression
... to topo IIβ ...in topo IIβ-silenced cells, confirming the antagonistic effects of RhoA and Cdc42 in neurite ...in topo II β knockdown cells, supporting the hypoth- esis that Rac1 primarily controls ...
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