TP53 Mutations
Clinical implications of TP53 mutations in myelodysplastic syndromes treated with hypomethylating agents
... of TP53, and the 53-gene panel covered the entire coding sequence of exons 4-8 and part of exons 2 and ...the TP53-mutated patients had longitudinal assessment of TP53 mutations by polymerase ...
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TP53 Mutations and Chemotherapy Response to Neoadjuvant Metotrexate, Cisplatin and Adryamicin Chemotherapy in Resected Osteosarcoma
... The TP53 gene was defined as the tumor suppressor gene due to its ability to suppress the malignant growth of transformed cells as well as tumors ...The TP53 gene locates in chromosome 17 (17p13), a region ...
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Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
... that TP53 mutations had the most distinct effects in CMS1 and CMS4, and were associated with significant dysregulation of 20 (40%) and 24 (48%) of the gene sets, respectively, compared with 7 (14%) in CMS3 ...
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TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting
... frameshift TP53 mutations was ...domain mutations. As suggested [40], however, not all of these mutations have the same impact on patient ...p.Arg248Gln mutations may confer favorable ...
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Role of TP53 mutations in triple negative and HER2-positive breast cancer treated with neoadjuvant anthracycline/taxane- based chemotherapy
... of TP53 status on response to high-dose/dose-dense neoadjuvant cyclophosphamide was seen [13, ...of TP53 mutations in therapy response might be dependent on the chemotherapy regimen and components ...
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Survival of patients with structurally-grouped TP53 mutations in ovarian and breast cancers
... a TP53 mutation, TP53 mutation type, genomic and codon locations, TP53 DNA CNA, relative TP53 mRNA and p53 protein expression levels, and total number of mutations (considering all ...
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Molecular Analyses of Early Onset Gastric Cancer in Brazilian Patients: TP53 Mutations, Cadherin Catenin and Mucins Proteins Expression
... TP53 mutations were found to be rare events, occur- ring in ...of TP53 is not a major event in EOGC in this ...germline TP53 variant due to a widespread founder effect in the population of ...
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<p>Concurrent TP53 mutations predict poor outcomes of EGFR-TKI treatments in Chinese patients with advanced NSCLC</p>
... study, TP53 mutations were the most com- mon concurrent mutation in Chinese patients with EGFR mutant ...concurrent TP53 alterations are associated with a lower likelihood of response to EGFR-TKIs, ...
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Clinical significance of frequent somatic mutations detected by high throughput targeted sequencing in archived colorectal cancer samples
... different TP53 mutations were detected in 64 patients ...mon mutations affecting arginine residues 175 (6 cases; ...Furthermore, TP53 mutations are largely concentrated in the DNA ...
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Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early onset breast cancer patients
... for TP53 mutations due to the presence of the child- hood ...as TP53 carriers, in addition to her two affected children and her younger sister with osteosarcoma ...
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Search | Preprints
... by TP53 mutations, and because fallopian tubes frequently contain early serous proliferations (ESPs) with these mutations, attention has turned to the possibility that nonmalignant but TP53 ...
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Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection.
... human TP53 were knocked in the corresponding mouse exons, are useful models for studying human TP53 mutagenesis 33, 48, 49 ...human TP53 gene of gastric mucosa derived from Hupki mice with, and ...
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Prognostic and predictive value of TP53mutations in node positive breast cancer patients treated with anthracycline or anthracycline/taxane based adjuvant therapy: results from the BIG 02 98 phase III trial
... (truncating mutations that stain negative), and a poor level of cor- relation with TP53 gene mutations ...assess TP53 status have produced more consistent results for the prognostic value of ...
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Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma
... carrying TP53 mutations have reduced survival compared to those with a wild-type status [6, 7], the prognostic impact of different types of TP53 mutations remains poorly ...the ...
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Lobular breast cancer: incidence and genetic and non genetic risk factors
... by mutations in the tumour-suppressor gene ...germline TP53 mutations, but the two stud- ies that have examined the issue have only shown tumors of the ductal type - and none of the lobular type - ...
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Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples
... genes; TP53, P16, SMAD4 and APC was ...of TP53 alterations: all five EACs where homogeneous with regard to TP53 mutations and LOH of the TP53 locus, in addition the same mutation and ...
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Retrospective study testing next generation sequencing of selected cancer-associated genes in resected prostate cancer
... in TP53 were the most common GVs and this observation agrees with previously published data that since early ‘90s documented TP53 mutations in PCa [8, ...“deleterious” TP53 mutations ...
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Chondrosarcoma of the spine: A rare case with unusual presentation
... and TP53 mutations are detected primarily in high-grade, advanced ...The TP53 gene appears to be inacti- vated late in the course of chondrosarcoma and may be associated with disease ...
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NKX2–1 expression as a prognostic marker in early-stage non-small-cell lung cancer
... K-RAS mutations were de- tected in 19.1% of all patients and TP53 mutations in ...of TP53 mutations by exon was: 12 mutations in exon 5; six in exon 6; five in exon 7; and ten in ...
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Immunohistochemical correlates of TP53 somatic mutations in cancer
... of TP53 mutations occur within exons 5-8 ...Point mutations in TP53 introns can abrogate the function of any remaining normal p53 ...detectable mutations were single base-pair ...
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