Trans-retinoic acid
Influence of two promising products (silibinin and trans retinoic acid) on immunophenotypic characterization of leukemic cells propagated ex vivo
... 1μM trans retinoic acid (TRA), A3: NCL treated with 10μg /ml silibinin, and A4: NCL treated with 1μM trans retinoic acid +10 μg/ml ...with1μM Trans Retinoic ...
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Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
... gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanopar- ticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) ...
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Potential for combined delivery of riboflavin and all trans retinoic acid, from silk fibroin for corneal bioengineering
... Millions of people worldwide su ff er from vision impairing conditions resulting from corneal injury or disease. Silk fibroin (SF) is an emerging biopolymer that has been used for several applications including the ...
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Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
... Abstract: This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was ...
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All Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy
... all-trans retinoic acid (ATRA) on protein kinase C (PKC)-α (A), β (B), δ (C) expression at 24 hrs in rat mesangial cells (RMCs) in media containing 30 (high) or 5 (control) mM of ...
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Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A
... Granulocyte colony-stimulating factor (G-CSF) is a myeloid growth factor that promotes proliferation, survival, and differentiation of myeloid-lineage leukemic cells, as well as normal hematopoietic cells [1,2]. Clinical ...
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The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
... trans retinoic acid (ATRA), induce disease stabilization with improvement of normal peripheral blood cell counts for a subset of AML ...proic acid and low-dose cytarabine, but these patients ...
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All trans retinoic acid modulates the retinoic acid receptor alpha in promyelocytic cells
... all-trans retinoic acid (RA), the active metabolite of vitamin A, is an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia ...the retinoic acid ...
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Effect of all-trans retinoic acid on the proliferation and differentiation of brain tumor stem cells
... CD133 and GFAP immunofluorescence detection of the expression per- centages after 10 days of induction by ATRA showed that CD133 expression did not disappear in both groups, indicating t[r] ...
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A fourth subtype of retinoic acid receptor-related orphan receptors is activated by oxidized all-trans retinoic acid in medaka (Oryzias latipes)
... amino acid sequence used in phylogenetic ana- lysis) was amplified by PCR and cloned into ...were trans- fected with 500 ng luciferase reporter plasmid (bmal1ap- luc or cyp26a1p-luc) and 50 ng expression ...
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THE EFFECT OF ALL-TRANS RETINOIC ACID AND FATTY ACIDS ON MCF-7 BREAST CANCER CELL PROGRESSION
... hypothesized the connection with these compounds to be found on the nuclear level in the form of transcription factor specific receptors: Perxisome-proliferator activated receptor gamma (PpARy), and Retinoic ...
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All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
... Upon ATRA treatment, we detect a decrease in mRNA level of both lamin A and progerin with respect to untreated cells suggesting that ATRA is effective on LMNA gene at the transcriptional[r] ...
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The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... RA: Retinoic acid; ATRA: All-trans retinoic acid; RAR α : Retinoic acid receptor alpha; RXR: Retinoid X receptor; PBMC: Peripheral blood mononuclear cells; HDM: House dust ...
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<p>A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review</p>
... A 32-year old woman was fi rst hospitalized for menorrhagia and severe tiredness. Anemia with a hemoglobin of 64 g/L and low platelet count of 33×10 9 /L were noted. Blast cells were also observed in the peripheral blood ...
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Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
... Cucurmosin also inhibits proliferation and induces apoptosis in tumor cells; inter- estingly, cucurmosin combined with trans-retinoic acid or arsenic trioxide was shown to synergistica[r] ...
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Case Report Late isolated extramedullary relapse of acute promyelocytic leukemia present as chronic otitis media: case report and literature review
... all-trans retinoic acid (ATRA) in treatment regimens of Acute Promyelocytic Leukemia (APL), vast majority of patients achieved complete remissions ...
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The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
... Only one subtype of AML, acute promyelocytic leuke- mia (APL), displays a much better prognosis, as differenti- ation therapy with arsenic trioxide or all-trans retinoic acid (ATRA), used alone or in ...
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Efficacy of commercially available biological agents for the topical treatment of cervical intraepithelial neoplasia: a systematic review
... All-trans retinoic acid (atRA) is an active metabolite of vitamin A under the family ...apoptosis. Retinoic acid either decreases or increases EGF- stimulated growth and epidermal ...
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Dual effect of oxidative stress on leukemia cancer induction and treatment
... lipoic acid; ALL: Acute lymphoblastic leukemia; AML: Acute myeloid leukemia; Ang II: Angiotensin II; ATO: Arsenic trioxide; ATRA: All-trans retinoic acid; CALLA: Common acute lymphoblastic ...
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A review of arsenic trioxide and acute promyelocytic leukemia.
... Arsenic trioxide (ATO) is very potent as a single agent against acute promyelocytic leukemia (APL). This old drug was reintroduced into new medicine by Chinese studies on APL treatment and rapidly approved by the FDA ...
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