Transcription factor Sp1
Transcription Factor Sp1 Mediates Cell-Specifictrans-Activation of the Human Cytomegalovirus DNA Polymerase Gene Promoter by Immediate-Early Protein IE86 in Glioblastoma U373MG Cells
... tissue-specific factor(s) or the functional modification of a cellular transcrip- tion ...cellular transcription factor ...between Sp1 and the IE86 protein or by a posttranslational ...
9
Phosphorylation of Transcription Factor Sp1 during Herpes Simplex Virus Type 1 Infection
... for Sp1, upstream of the TATA box, while late gene promoters generally lack such ...that Sp1 function may be altered during the course of infection, the modification state and activity of Sp1 were ...
7
Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia
... and Sp1 in U87 tumor cells Real-time RT-PCR was performed to determine whether Sp1 transcription factor mediates ADAM17 expression under normoxic and hypoxic ...ADAM17, Sp1 and HIF-1α ...
9
TMPRSS2-ERG fusion protein regulates insulin-like growth factor-1 receptor ( IGF1R ) gene expression in prostate cancer: involvement of transcription factor Sp1
... the transcription factor ERG. The insulin-like growth factor-1 receptor (IGF1R) plays a key role in cell growth and tumorigenesis, and is overexpressed in most malignancies, including prostate ...and ...
18
The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter.
... The CArG-140, SP1-130, and SP1-50 elements are necessary for p19 promoter activity. To determine the role of each p19 interaction for promoter activity, we constructed a series of substitution mutations ...
10
A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.
... this factor is crucially ...in transcription factor assemblies to alter cell fates (Heinz et ...as Sp1 or Oct1 arrests development at an early developmental stage (Marin et ...expressed ...
12
The evolutionarily conserved transcription factor Sp1 controls appendage growth through Notch signaling
... of Sp1 An ancient common mechanism for the formation of outgrowths from the body wall has been suggested (Gonzalez-Crespo et ...Drosophila Sp1 mutants, mouse Sp8-deficient embryos develop with truncated ...
9
Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1.
... Although interactions of wild-type and mutant forms of v-Rel with Spl correlate with their abilities to form heterodimers and to increase transcriptional activation by Spl, there is no c[r] ...
8
Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors
... of Sp1 protein levels has been demonstrated to be induced in MM cells by bortezomib largely through caspase-8 activation and thereby enzymatic Sp1 protein degradation, indicating a predominant role of ...
12
Naturally occurring mutations in the human 5 lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription
... 5-LO transcription factor binding region, EMSAs were used to detect specific DNA-nuclear protein ...ubiquitous transcription factor Sp1 is known to bind the functionally important ...
9
LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms
... of Sp1 trancription factor. Sp1 is the founding member of a family of zinc finger transcription factors, which includes at least four Sp tran- scription factors ...Sp transcription fac- ...
10
The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast like synoviocytes
... finger-type transcription factor Sp1-binding sites, including those in numerous housekeeping and inducible genes [18], in the interferon-stimulated response element (ISRE), and in the gamma-activated ...
9
Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells
... multiple Sp1 binding sites, and transcription factor Sp1 binding could promote MGMT expression(Bocangel et ...detect Sp1 expression in HCT116 cells after treatment (48 h) with TMZ (50 ...
19
Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... yeast transcription factor GAL4 (preys), whereas the FG-repeat regions of assorted yeast and vertebrate nucleopor- ins were expressed as carboxy-terminal fusions to the GAL4 DNA binding domain ...
10
In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.
... Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type 1 tat proteins occurs in the absen[r] ...
10
DNA methylation status of TBX20 in patients with tetralogy of Fallot
... (Pierce™). Sp1 antibodies were obtained from Abcam. Sp1 overexpres- sion was verified by Western ...a Sp1 binding site (Biotin-TBX20– 708/− 684) and a mutant biotin-labelled oligonucleotide probe ...
10
The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex.
... presses transcription from the SV40 early promoter, and binds the tumor suppressor proteins Rb, p53, and ...late transcription in the absence of either viral DNA replication or sequence-specific DNA binding ...
12
Regulation of microRNAs by epigenetics and their interplay involved in cancer
... The deregulated miRNAs that can be controlled by epigenetic drugs in human cancers are shown in Table 1. These agents can either cause the re-expression of si- lenced tumor suppressor miRNAs or repress oncogenic miRNAs ...
8
Characterization of functional Sp1 transcription factor binding sites in the hepatitis B virus nucleocapsid promoter.
... To investigate further the possibility that the same or similar factors might be binding to the nucleocapsid CpA, CpB, and CpC and major surface antigen B, D, D5', E, F, and F3' promoter[r] ...
10
Regulation of the ITGA2 Gene in prostate cancer
... growth factor-β (TGFβ) to the TGFβ receptor (TGFβr), growth factors such as epidermal growth factor (EGF), fibroblast growth factor (FGF) and hepatocyte growth factor (HGF) which bind to their ...
198