transcriptional reprogramming
Transcriptional Reprogramming and Backup Between Duplicate Genes: Is It a Genomewide Phenomenon?
... expression reprogramming capability, a duplicate gene has to be able to recognize its sister copy even after substantial changes at both expression and sequence ...
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Transcriptional reprogramming underpins enhanced plant growth promotion by the biocontrol fungus Trichoderma hamatum GD12 during antagonistic interactions with Sclerotinia sclerotiorumin soil
... underlying transcriptional reconfiguration that is associated with functionally known and novel transcripts that are recruited to deploy the diverse armory of cryptic chemistries that are potentially encoded in ...
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HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes
... In order to investigate the mechanism of transcriptional reprogramming by oocytes, we have first monitored the transfer of histone variants between the oocyte and the transplanted nuclei. We have focused ...
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Transcriptional reprogramming in yeast using dCas9 and combinatorial gRNA strategies
... optimizing transcriptional reprogram- ming is using other dCas9 ...If transcriptional regulation is a matter of titration of transcriptional effectors, introducing such domains into dCas9 hotspots ...
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Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes
... retarded transcriptional reprogramming of pluripotent genes because their promoter and regulatory regions form bivalent domains in 10T1/2 nuclei, but the strong increase of H3K4 me3 without an H3K27 me3 ...
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Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection
... etic transcriptional reprogramming during metamor- phosis, following wounding and during infection with virulent bacteria in ...resulting transcriptional re- programming this has a collateral impact ...
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Transcriptional reprogramming of Arabidopsis thaliana defence pathways by the entomopathogen Beauveria bassiana correlates with resistance against a fungal pathogen but not against insects
... for transcriptional reprogramming of plant defence pathways, with strain-specific changes in the expression of genes related to pathogenesis, phytoalexin, jasmonic (JA), and salicylic acid (SA) signalling ...
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Transcriptional reprogramming of metabolic pathways in critically ill patients
... human leukocytes (monocytes) underwent metabolic reprogramming in the early phase of sepsis [18]. In the work performed by Tannahill et al., macrophages stimulated by lipopolysaccharide underwent up-regulation of ...
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Baumann, Valentin (2019): Identification and manipulation of chromatin barriers in transcriptional reprogramming. Dissertation, LMU München: Graduate School of Systemic Neurosciences (GSN)
... My findings not only address potential obstacles of trans-activation, but also point out a profound divergence between the potency of a TAF to induce a target gene to high levels, and its efficiency to do so in a high ...
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Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes
... any transcriptional changes related to metabolism ...eral transcriptional up-regulation in T2D versus controls, even though individual genes showed mixed directions of ...
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Learning from failure: congestive heart failure in the postgenomic age
... expression. Transcriptional reprogramming has moved beyond being viewed as just a molecular marker of hypertrophic phenotypes or as an osten- sibly beneficial adaptation to being considered instrumental to ...
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Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers
... bone marrow cell-specific gene Slc4a1 was highly ex- pressed only in the original somatic cells of the iPS 16-6 cell line before reprogramming. However, there was no difference in its expression level or ...
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Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl 2 proteins as novel therapeutic targets for cancer
... A consistent feature of tumor metabolism is increased glycolysis and glutaminolysis, both of which are used to supply the intermediates required to sustain amino acid synthesis, the pentose phosphate pathway, and lipid ...
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Epigenetic Mechanisms Governing Behavioral Reprogramming In The Ant Camponotus Floridanus
... how transcriptional activity is altered by HDACi in d10 Major brains, we injected d10 Majors and prepared RNA-seq libraries 1h and 3h after treatment, as ...
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Regeneration and reprogramming compared
... not enough to confer real pluripotency reverting the blas- tema cells to a completely reprogrammed state, however, that a synergistic effect of pou5f1 together with other pluripotency genes, could enable these cells to ...
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Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection
... FIG 3 Differential sncRNA expression, gene set enrichment analysis, and biomarker screening reveal a modest degree of sncRNA reprogramming in LTBI. Analyses were performed on the basis of the 17 sncRNA that passed ...
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Nuclear reprogramming in zygotes
... The paternal genome, on the other hand, undergoes extensive remodeling in the zygote. Highly basic protamines that densely pack the sperm DNA become rapidly replaced by maternally provided histones in the zygote. This ...
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Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells
... This is the first reported study to investigate the effects of mechanical (equiaxial) stretching on the preparation of human iPSCs. While there was no positive effect on virus infection, the stretched groups formed a ...
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Age reprogramming and epigenetic rejuvenation
... whether reprogramming of eAge is separable from the developmental reprogram- ming resulting in iPS cells remained ...eAge reprogramming is indeed separable from devel- opmental ...after reprogramming ...
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Induced Pluripotent Stem Cell Clones Reprogrammed via Recombinant Adeno-Associated Virus-Mediated Transduction Contain Integrated Vector Sequences
... equal amounts of rAAVs containing the OCT4, SOX2, and KLF4 genes and c-Myc expressed under the control of the CMV or CAG promoter were added to the cells, which were transduced 1 to 4 times every second day (see Table S1 ...
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