transforming growth factor-beta
Coordinate regulation of transforming growth factor beta gene expression and cell proliferation in hamster lungs undergoing bleomycin induced pulmonary fibrosis
... The number of mesenchymal cells, as well as their ability to synthesize extracellular matrix (ECM) components, greatly increase in the interstitium of fibrotic lungs. We have previously shown that the transcription of ...
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Recombinant latent transforming growth factor beta 1 has a longer plasma half life in rats than active transforming growth factor beta 1, and a different tissue distribution
... Transforming growth factor beta 1 (TGF-beta 1) is a key regulator of cell growth and differentiation. Under normal physiological conditions, it is made as a biologically latent ...
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Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells
... of transforming growth factor alpha (TGF alpha), and transforming growth factor beta (TGF beta) was assessed in isolated primary rat intestinal epithelial cells as ...
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Transforming growth factor-beta and endoglin signaling orchestrate wound healing
... Transforming growth factor beta is an important growth fac- tor that regulates different cellular functions in all phases of wound healing (Table 1; Figure 2), including ECM production, ...
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Immunohistochemical expression of osteocalcin, transforming growth factor beta 1 and bone morphogenetic protein 7 in fibrous dysplasia and ossifying fibroma of the jaw bones (a comparative study)
... including growth factors, and hormones among others (Sobral et ...cell growth which will either stimulate or inhibit proliferation of mesenchymal cells depending on the presence of other growth ...
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Cellular distribution of transforming growth factor beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride induced rat liver fibrosis
... from transforming growth factor-beta 1 (TGF-beta 1) and procollagen alpha 1(I), alpha 1(III), and alpha 1(IV) genes were studied in carbon tetrachloride (CCl4)-induced rat liver ...
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Regulation of transforming growth factor beta (TGFβ) at the level of nuclear entry
... transcription Factor (RUNX) family members (Hanai 1999, Aliston 2001, Agas 2013), Olf/EBF-associated zink-finger Protein (OAZ) (Hata 2000), Activator Protein 1 (AP1) family (Zhang 1998, Sunqvist 2013), Electron ...
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Dog mastocytoma cells produce transforming growth factor beta 1
... TGF beta 1 by four dog mastocytoma cell lines. TGF beta 1 was identified by characteristic biologic activity, blockade of biologic effect by specific neutralizing antibody, and by recognition of a band with ...
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Transforming growth factor beta regulates thyroid growth Role in the pathogenesis of nontoxic goiter
... and growth regulatory activity of transforming growth factor beta were studied in human thyroid ...samples, transforming growth factor beta was produced in ...
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Inorganic pyrophosphate generation by transforming growth factor beta 1 is mainly dependent on ANK induction by Ras/Raf 1/extracellular signal regulated kinase pathways in chondrocytes
... It is generally recognized that a local buildup of excess extra- cellular inorganic pyrophosphate (ePPi), the anionic compo- nent of CPPD crystals, supports CPPD formation [6]. Intracellular inorganic pyrophosphate ...
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Altered expression of small proteoglycans, collagen, and transforming growth factor beta 1 in developing bleomycin induced pulmonary fibrosis in rats
... proteoglycans (biglycan, decorin, and fibromodulin), collagen III and TGF-beta 1 was studied by RNA-transfer blot analysis. The proteoglycans were also studied by SDS- polyacrylamide gel electrophoresis and ...
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Ubiquitin specific proteases as therapeutic targets for the treatment of breast cancer
... of transforming growth factor beta (TGFβ) signaling, which has a well-documented role in mediating epithelial-to- mesenchymal transition (EMT), tumor progression and metastasis in breast ...
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Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta
... The present study enlightens a mechanism of feedback loop controlling TGF b responses in human OA chon- drocytes. Contrary to previous studies, which examined one particular gene, we investigated the TGFb-induced ...
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Lack of transforming growth factor β signaling promotes collective cancer cell invasion through tumor stromal crosstalk
... Transforming growth factor beta (TGF- b ) is a pleiotro- pic cytokine that regulates growth arrest, cell motility, development, and differentiation ...II transforming ...
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Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals
... TGF beta 1 suppressed the evolution of arthritis even when administration was begun after the acute phase of the ...TGF beta 1 treatment greatly reduced inflammatory cell infiltration, pannus formation, and ...
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Influenza virus neuraminidase activates latent transforming growth factor beta.
... Transforming growth factor b (TGF- b ) is a family of proteins secreted by virtually all cells in a biologically inactive form. TGF- b levels increase during many pathophysiological situations, ...
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Contemporaneous trends and recent advances in bone augmentation for dental implant placement
... formation for implant placement (Boyan et al., 2006; Misch, 2010). Studies have also found rhBMP-2 is applicable to maxillary sinus floor augmentation (Boyne et al., 2005). However, many surgeons have questioned the use ...
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Original Article Genetic susceptibility to keloid scarring in Chinese Han population: NEDD4 gene single nucleotide polymorphism
... Abstract: Keloid disease (KD) is a benign fibroproliferative dermal tumor of unknown aetiology. The increased famil- ial clustering in KD, its increased prevalence in certain races and increased concordance in identical ...
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Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor beta
... Previous investigations have demonstrated that growing mesangial cells in high glucose concentration stimulates extracellular matrix synthesis and also increases the expression of TGF-beta. We tested whether the ...
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The dynamic roles of TGF β signalling in EBV associated cancers
... While most of the studies on the TGF-β pathway to date have focused on the roles of canonical Smad2/3/4-dependent signalling, emerging evidence has revealed the contribution of non-canonical Smad1/5/9 signalling ...
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