transgenic mouse
Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma
... determined transgenic mouse strain in which ligand-dependent acti- vation of TGF-β signaling occurs selectively in fibroblasts (Tβ ...in transgenic cells, but for transcripts induced at 12 hours when ...
11
The effects of Rhes, a striatal specific protein, on the expression of behavioral and neuropathological symptoms in a transgenic mouse model of Huntington's disease
... huntingtin protein (mHtt) is ubiquitously expressed in HD patients, cellular degeneration occurs only in neurons within the striatum and cerebral cortex. The Ras homolog Rhes is expressed very selectively in the precise ...
64
Hypoxia induced in vivo sickling of transgenic mouse red cells
... created transgenic mice that express a severe naturally occurring human sickling hemoglobin, Hb S ...make transgenic animals that express a high level of Hb S Antilles, the erythroid-specific DNAse I ...
10
Microarray analysis of gene expression in the liver of transgenic mouse model of HCV infection
... genic mouse model expressing HCV structural pro- teins Core, Envelope 1 (E1) and Envelope 2 (E2) us- ing complementary DNA (cDNA) ...HCV transgenic and non-transgenic mice was analyzed with cDNA ...
9
How to build an inducible cartilage specific transgenic mouse
... in transgenic mouse models are not solely due to the promoter/enhancer regions that drive the trans- gene as different sites of integration can severely influ- ence the level of ...
11
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
... chromosome transgenic mouse model of HD ...(SCA3) mouse models and demonstrated that treatment with dantrolene, a ryanodine receptor antagonist and clinically relevant Ca 2+ signaling stabilizer, was ...
12
Physiology of anergic CD8 T cells in a transgenic mouse model
... aII transgenic CD4 T cells was induced in vivo by Vp3 specific superantigen staphyloccocal enterotoxin A (SEA), as m easured by subsequent restim ulation in vitro with antigen or ...
201
Characterization of a Trpc6 Transgenic Mouse Associated with Early Onset FSGS
... and Mouse-to-Mouse Blocking Reagent according to the manufacturer instructions (ScyTek ...108A; Mouse anti Synaptopodin 1:80, Progen ...anti Mouse AF488 ...
15
The effects of chronic simvastatin treatment on the expression of behavioral symptoms in a transgenic mouse model of Huntington’s disease
... incidental phenomenon of cellular dysfunction (Kuemmerle, Gutekunst, Klein, Li, Li, Beal et al., 1999). Evidence for a more “side-effect” role is found in studies of human post-mortem HD brains that demonstrate the ...
53
A transgenic mouse assay for agouti protein activity.
... Based on our experiments with the wild-type agouti cDNA, we would have expected 11 of the found- ers carrying the mutant agouti cDNA to display yellow pigmentation if t[r] ...
8
The study of dopamine dynamics in transgenic mouse models
... In addition, 1 mM urethane is unable to significantly alter stimulated dopamine release in the striatum (Figure 8.4A, p > 0.05, n = 5). A similar trend is seen in stimulated 5-HT.. F[r] ...
184
Activation of the lac Repressor in the Transgenic Mouse
... As summarized in Table 1 , bacterial Zncl sequences resident at 14 unique transgene loci that differed by copy number and insertion site, in hvo different hybrid genet[r] ...
8
Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen
... from mouse pancreas the transgene was detected by rtPCR (figure 1c: lane ...the mouse pancreas, zymogen granules were prepared, the proteins were separated by isoelectric focussing, trans- ferred on ...
10
A transgenic mouse model of systemic lupus erythematosus
... careful follow up of patients. However, it cannot be taken advantage of because of the ineffectiveness of current therapies. We currently lack a readily useable therapeutic agent which can affect the humoral autoimmune ...
200
Multiple tissues express alpha 1 antitrypsin in transgenic mice and man
... understood. Transgenic mice that express the normal human AAT gene demonstrate abundant AAT in hepatocytes and specific cell types of numerous nonhepatic ...in transgenic mice; however, the issue of local ...
12
Expression and regulation of neuron specific enolase
... from transgenic mouse experiments showed, however, that reporter transgenes driven by relatively short regions of 5' and 3' flanking sequence were properly regulated, indicating that all the required m ...
418
Index Catalog // Carolina Digital Repository
... R6/2 transgenic mouse model of Huntington’s disease (Johnson et ...R6/2 transgenic mouse model is one of the models which has been used extensively in the research of this disease (Levine et ...
185
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
... a transgenic mouse model in which human PTEN is overexpressed in ductal and alveolar mammary epithelium during puberty, pregnancy, lactation, and ...retardation. Transgenic offspring nursed by ...
12
Functional resolution of duplicated hoxb5 genes in teleosts
... in mouse embryos at E10.5, E12.5 and E13.5. Transgenic mouse embryos, either primary or from established lines, showed lacZ expression in regions that coincide with domains of mouse Hoxb5 ...
11
Lentiviral-Mediated Transgene Expression Can Potentiate Intestinal Mesenchymal-Epithelial Signaling
... many transgenic mouse lines with modifica- tions in the Wnt signaling pathway exist, most harbor pertur- bations in downstream effectors, such as Apc or ...knockout mouse lines in existence result in ...
15