translation initiation factor eIF2
The IE180 Protein of Pseudorabies Virus Suppresses Phosphorylation of Translation Initiation Factor eIF2α
... eukaryotic translation initiation factor eIF2 ␣ ...of eIF2 ␣ has been reported earlier for the closely related alphaherpesvirus herpes simplex virus 1 (HSV-1) through its ...with ...
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Two Genes Become One: The Genes Encoding Heterochromatin Protein SU(VAR)3-9 and Translation Initiation Factor Subunit eIF-2γ Are Joined to a Dicistronic Unit in Holometabolic Insects
... The Drosophila suppressor of position-effect variegation Su(var)3-9 encodes a heterochromatin-associ- ated protein that is evolutionarily conserved. In contrast to its yeast and mammalian orthologs, the Drosophila ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer required for GTP-dependent delivery of initiator tRNA to the ...exchange factor for eIF2, is a ...
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The Biological Roles of Translation Initiation Factor 3b
... essential for rigorous AUG recognition [9,21,22]. Similarly, PRT1, a homolog of eIF3b in yeast, binds TIF32 (eIF3a), TIF35 (eIF3g), TIF34 (eIF3i), HCR1 (eIF3j), and Pci8 (eIF3e), which highlight the conserved nature of ...
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Depletion of eIF2 GTP Met-tRNA translation initiation complex up-regulates BRCA1 expression in vitro and in vivo
... the translation- competent 80S ribosome is assembled to commence protein ...the eIF2·GDP complex [27]. Initiation of a new round of translation requires recycling of eIF2·GDP to ...
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Diverse roles of endoplasmic reticulum stress sensors in bacterial infection
... 1; eIF2 α : eukaryotic translation initiation factor 2 α ; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ESAT-6: early secretory antigenic target 6; Grp94: heat shock protein 90 ...
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The Alpha Subunit of Eukaryotic Initiation Factor 2B (eIF2B) Is Required for eIF2-Mediated Translational Suppression of Vesicular Stomatitis Virus
... to eIF2 ␣ ...that eIF2-eIF2B regulation is largely nonresponsive in HeLa cells, and this seems to be a common characteristic among many tumor cells ...deregulate eIF2 ␣ phosphorylation, it is highly ...
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Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
... eukaryotic translation initiation factor 2 α (eIF2 α ) was shown to enhance long-term memory and synaptic plasticity in naïve ...of eIF2 α is observed in the brains of postmortem AD ...
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PubMedCentral-PMC4848592.pdf
... the translation “start” codon ...a translation start site, which almost always consists of an AUG methionine codon in a favorable sequence context ...eIF5 initiation factors position the tRNA Met ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... large initiation factor eIF4G, an interaction that is inhibited by association of eIF4E with the small 4E-binding proteins ...karyotic translation initiation factor 2 ␣ (eIF2 ␣ ) ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... that translation initiation factors play a key role in regulating certain functional proteins to promote cell ...tic initiation factor 2 α (eIF2 α ) plays a key role in regulat- ing ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... Translation initiation in eukaryotes requires the parti- cipation of several eukaryotic initiation factors (eIFs), and the eIF3 is the largest and most complex of the eIFs, consisting of 13 subunits ...
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Activation of AP-1-Dependent Transcription by a Truncated Translation Initiation Factor
... tion initiation factor, ...multisubunit translation initiation factor eIF3, a view supported here by our TAP-tagging data ...the translation of mRNAs transcribed in a pap1-depen- ...
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mRNA Decay during Herpesvirus Infections: Interaction between a Putative Viral Nuclease and a Cellular Translation Factor
... While this model is attractive in outline, many of its details FIG. 5. eIF4H binding by wild-type and mutant Vhs. (A) The structures of the wild-type Vhs protein and various mutants. For deletion mutants, the Vhs ...
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eIF5B increases ASAP1 expression to promote HCC proliferation and invasion
... eukaryotic translation initiation factor 5B (eIF5B) was significantly correlated with aggressive characteristics and associated with shorter recurrence-free survival (RFS) and overall survival (OS) ...
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Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... tles between the nucleus and the cytoplasm, is required for mRNA Posas, F., M. Takekawa and H. Saito, 1998 Signal transduction by 3 ⬘ -end formation in yeast. Genes Dev. 11: 2545–2556. MAP kinases in budding yeast. Curr. ...
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Taking aim at translation for tumor therapy
... It was previously appreciated that the determination of skeletal muscle fiber type (fast or slow) could be regulated by class II histone deacetylases (HDACs), which function by inhibiting the transcription factor ...
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Poliovirus Switches to an eIF2-Independent Mode of Translation during Infection
... of translation initiation ...to eIF2 ␣ phosphorylation, including cricket paralysis virus (CrPV), hepatitis C virus (HCV), and classical swine fever virus (CSFV) (41, 52, ...for initiation ...
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Regulation of Translation by Ribosome Shunting through Phosphotyrosine-Dependent Coupling of Adenovirus Protein 100k to Viral mRNAs
... on translation and mRNA transport might influence tripartite leader-100k inter- action, we suspect that there is no critical requirement for early proteins in 100k translation ...leader-directed ...
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Interaction of Translation Initiation Factor eIF4B with the Poliovirus Internal Ribosome Entry Site
... actual initiation codon further downstream is reached by ribosomal scanning (20, 22, 25, ...of initiation factors. In addition to the standard initiation factors, picornavirus IRES elements recruit ...
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