translation initiation factors 2
Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro.
... To further characterize La activity in translation and to identify other potential limiting factors, we assayed the ability of La protein as well as purified initiation factors, eIF-2, g[r] ...
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Cell-Type-Specific Growth Restriction of Vesicular Stomatitis Virus polR Mutants Is Linked to Defective Viral Polymerase Function
... eukaryotic translation initiation factor 2 (eIF-2 ␣ ) was enhanced ⬃ 3-fold in polR versus wild-type virus-infected L-929 cells, but neither inhibition of host gene transcription nor ...
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Translation Initiation Factor eIF4B Interacts with a Picornavirus Internal Ribosome Entry Site in both 48S and 80S Initiation Complexes Independently of Initiator AUG Location
... IRES-dependent initiation, bind- ing of initiation factors and entry of the small ribosomal sub- unit to the complex IRES structure involve RNA-protein and protein-protein interactions that require ...
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RNA Degradation in Saccharomyces cerevisae
... in translation initiation increase the pool of mRNAs in P-bodies (Teixeira et ...to translation (Brengues et ...with translation initation factors and RNA-binding proteins (reviewed in ...
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Foot-and-Mouth Disease Virus 3C Protease Induces Cleavage of Translation Initiation Factors eIF4A and eIF4G within Infected Cells
... of translation initiation factors was assessed by immunoblotting cell extracts with a panel of specific antibod- ...by 2 h postinfection cleavage is com- plete, consistent with previous data ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... that translation initiation factors play a key role in regulating certain functional proteins to promote cell ...tic initiation factor 2 α (eIF2 α ) plays a key role in regulat- ing ...
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VPg of murine norovirus binds translation initiation factors in infected cells
... To investigate interactions between VPg and eIFs in infected cells, RAW 264.7 cells were infected with MNV-1 and immunoprecipitations (IP) were performed follow- ing established protocols [13,15]. MNV-1 VPg was present ...
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Impaired Binding of Standard Initiation Factors Mediates Poliovirus Translation Attenuation
... these translation initiation factors and hence impair the association of the ribo- some with the viral ...reduced translation efficiencies of these con- structs ...these factors and not ...
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The sequence element of the internal ribosome entry site and a 25-kilodalton cellular protein contribute to efficient internal initiation of translation of hepatitis C virus RNA.
... cellular factors involved in initiation of HCV RNA trans- lation that bind to the 5 9 NCR regardless of the presence of alpha-branch ...Because translation of HCV RNA in 120 mM KCl retained about 80% ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... G 2 /M-phase-arrested ...cellular factors that are optimally expressed in G 2 /M to enhance virus translation or that the p17 protein play a direct role, partially explaining the p17 constant ...
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Genome-wide microRNA changes in human intracranial aneurysms
... ≥ 2), including 72 upregulated and 85 ...protein translation machinery, including various eukaryotic translation initiation factors and ribosomal proteins, and this finding was highly ...
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The IE180 Protein of Pseudorabies Virus Suppresses Phosphorylation of Translation Initiation Factor eIF2α
... could be that IE180 affects gene expression of cellular factors that influence the phosphorylation status of eIF2 ␣ . Although we pro- vide evidence that the cellular phosphatase PP1 is involved in IE180-mediated ...
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A socio-structural approach to preventing injection drug use initiation: rationale for the PRIMER study
... economic factors operating at mul- tiple ...individual-level factors such as OST enrolment, housing status, spatial proximity to non-injectors, income level, and level of drug dependence; meso-level ...
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Genomic RNA of mengovirus. VI. Translation of its two cistrons in lysates of interferon-treated cells.
... The sequences of mengovirus RNA recognized by ribosomes of interferon-treated cells at initiation of translation were compared with those present in initiation complexes formed by riboso[r] ...
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Translation initiation at a downstream AUG occurs with increased efficiency when the upstream AUG is located very close to the 5' cap.
... To determine whether the short length of the untranslated leader of this mRNA affects the efficiency of translation initiation at the LP1 initiation signal, monkey cells were transfected[r] ...
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Mechanism of selective translation of vaccinia virus mRNAs: differential role of poly(A) and initiation factors in the translation of viral and cellular mRNAs.
... In order to further study the difference between HeLa and VV mRNA sensitivities to polyA-mediated inhibition of translation, we compared the translation of deadenylated HeLa and VV mRNAs[r] ...
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PubMedCentral-PMC4848592.pdf
... the translation of several host mRNAs is simultaneously decreased ...facilitates translation of cellular mRNAs under eIF4F-limiting ...that translation initiation on HCMV mRNAs differs from ...
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Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease
... eukaryotic translation initiation factors were sug- gested as a host cell cofactor for viruses replication and propagation, including ...RNA translation and cap-dependent RNA ...
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Herpes Simplex Virus 1 Infection Activates the Endoplasmic Reticulum Resident Kinase PERK and Mediates eIF-2α Dephosphorylation by the γ134.5 Protein
... at 24 h and remained at a similar level at 72 h. Similarly, FIG. 2. (A) The effect of PAA on HSV-induced PERK activation. Monolayers of mouse NIH 3T3 cells were infected with the indicated viruses at 10 PFU per ...
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Inhibition of TANK Binding Kinase 1 by Herpes Simplex Virus 1 Facilitates Productive Infection
... Mice, cells, and viruses. BALB/c mice were purchased from Harlan Sprague Dawley Inc. and housed under specific-pathogen-free conditions in biosafety level 2 containment. Groups of 6-week-old mice were selected for ...
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