TRANSLOCATION ACROSS THE MEMBRANE
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons
... Edited by Roger J. Colbran Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including fronto- temporal dementia. We have previously shown that patient- derived VCP ...
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Protein translocation across the gram negative bacterial membrane /
... outer membrane of ...large membrane proteins which was incorporated into ...the membrane scaffold protein is flexible as a larger nanodisc can be ...
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The Structural Organization of Skeletal Proteins Influences Lipid Translocation across Erythrocyte Membrane*
... Based on the findings that extensive oxidative cross-linking of membrane proteins in normal red cells induces profound alterations in both phospholipid distribution and rate[r] ...
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tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes
... More than 35 different tRNAs need to be imported into the trypanosome mitochondrion in quantities sufficient to support organellar translation (30). Thus, in analogy to mitochondrial protein import, factors that mediate ...
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Banerjee, Rupa (2018): Molecular mechanisms of protein translocation across mitochondrial inner membrane. Dissertation, LMU München: Medizinische Fakultät
... Tim44 recruits different subunits of the import motor to the translocation channel of the TIM23 complex, including the ATP-consuming subunit Ssc1. Ssc1 is an essential protein that belongs to Hsp70 family of ...
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Allosteric signalling in the outer membrane translocation domain of PapC usher
... the translocation across the outer membrane of P-pili, and its gating mechanism is important for bacterial homeostasis and for catalysis of pilus ...
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Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase
... and translocation across the parasitophorous vacuolar membrane (PVM) for dense granule (GRA) ...GRA translocation and selected one with a partial defect, suggesting it might be in a gene ...
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Protein Translocation Across Planar Bilayers by the Colicin Ia Channel-forming Domain Where Will It End?
... the membrane of the amino terminus of the carboxy-terminal fragments CT-S, CT-M, and CT-L was assayed by addition to the trans solution of either His-tag antibody, which could bind to the amino-terminal His-tag on ...
Mutational Analysis of Glycosylation, Membrane Translocation, and Cell Surface Expression of the Hepatitis E Virus ORF2 Protein
... posttranslational translocation of ...posttranslational translocation, the transla- tion reaction was terminated with cycloheximide and in vitro- synthesized proteins were incubated with microsomal mem- ...
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Sequential Translocation of Polypeptides across the Bacterial Outer Membrane through the Trimeric Autotransporter Pathway
... the translocation of all of the passenger domains was initiated normally, it seems likely that translocation was rapid until the nonnative segments approached the ...potential across the OM (62) or ...
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Hsp70 at the membrane: driving protein translocation
... Hsp70s in the mitochondrial matrix and the ER lumen play a critical and more active role in protein transloca- tion than do those on the cytosolic side. They form the core of the machinery, often called “import motors”, ...
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Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane
... outer membrane translocon is suggested to be responsible for forming the periplasmic slide with LptA and LptC to transport LPS from the inner membrane to the outer ...
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Sec-facilitated Protein Translocation and Membrane Integration
... groups across membrane ...segment across membrane has proven to be challenging experimentally, in part due to uncertainty on the role of other TMs in facilitating this ...helix across ...
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Controlled membrane translocation provides a mechanism for signal transduction and amplification
... by membrane spanning proteins, without uncontrolled mixing of the two ...signals across bilayer ...a membrane-spanning protein receptor induces either a global conformational change ...introduce ...
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SecA mediates cotranslational targeting and translocation of an inner membrane protein
... with the SRP machinery. In addition, the consecutive basic residues immediately upstream of the TMD facilitate SecA re- cruitment. Enrichment of N-terminal basic residues correlated with enhanced signal sequence binding ...
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Transport of proteins into and across the thylakoid membrane
... Kim et al., 1998). Because insertion is not dependent on additional factor, FtsY, probably functions as a soluble signal peptide any of the known translocation apparatus, it has been receptor mediating transfer to ...
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Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine
... along two ways: transcellular or paracellular pathway. 15 The TEM images of RWM determined which one was the dominant role mediating the entry of PLGA NPs into RWM. NPs are endocytosed following three different ...
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DNA Membrane Anchor Facilitates Efficient Chromosome Translocation at a Distance in Bacillus subtilis
... a membrane protein which localizes to the cell ...forespore across the entire length of the chromosome, requiring nearly twice as much time to move a given DNA ...reduced translocation to a similar ...
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Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers
... the membrane scission protein, is a large GTPase which forms a helical polymer around the neck of newly-formed cell plasma membrane invaginations and, upon GTP hydrolysis, mediates the fission of the ...
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The Adenovirus E3-6.7K Protein Adopts Diverse Membrane Topologies following Posttranslational Translocation
... several membrane proteins, most of which are involved in immune evasion and prevention of host cell ...translocates across the membrane of the endoplasmic reticulum in a posttranslational, ...
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