transmembrane helix
Evidence that Insertion of Tomato Ringspot Nepovirus NTB-VPg Protein in Endoplasmic Reticulum Membranes Is Directed by Two Domains: a C-Terminal Transmembrane Helix and an N-Terminal Amphipathic Helix
... introduced N-glycosylation site. (A) Schematic representation of trun- cated proteins containing the N-terminal domain of NTB fused to an inserted artificial N-glycosylation site. Amino acids inserted at the N terminus ...
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Association of Protein Helices and Assembly of Foldamers: Stories in Membrane and Aqueous Environments
... of helix-helix interaction and highlighting the crucial ...soluble helix pairs cluster into a small number of distinct geometries, as has previously been shown for transmembrane helix ...
104
In silico structure analysis of potassium channel Bgk toxin and its docking prediction with human voltage gated potassium (Kv) channel
... bond, transmembrane helix, signal peptide, immunogenicity and phylogenetic tree and also to carry on docking study with a voltage gated potassium ...
9
Role of the Coronavirus E Viroporin Protein Transmembrane Domain in Virus Assembly
... a transmembrane ␣ -helix causes all amino acids on its carboxy side to be rotated by ⬃ 100 degrees, which disrupts the potential helix-helix packing interface of residues on both sides of the ...
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K+ amino acid transporter KAAT1 mutant Y147F has increased transport activity and altered substrate selectivity
... first transmembrane helix of KAAT1 led to results equivalent to those observed in the corresponding mutants of GAT1; namely, substrate (leucine) uptake and substrate-evoked net inward current were severely ...
10
Sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodaviruses
... In the noda group, the mode of membrane association seems taxon-specific. It can occur through an N-terminal segment, which forms a transmembrane helix in a few species (e.g. in Flock House virus, aa 15–36 ...
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Helix-Destabilizing, β-Branched, and Polar Residues in the Baboon Reovirus p15 Transmembrane Domain Influence the Modularity of FAST Proteins
... the transmembrane helix by  -branched and glycine residues may be needed to further destabilize the donor mem- brane, as suggested by recent peptide studies showing that a dynamic TMD helix ...
13
A Christianson syndrome-linked deletion mutation (∆287ES288) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death
... A variety of inherited and de novo mutations in NHE6 have recently been identified in CS patients, including frameshifts, nonsense, missense and deletions, although their precise consequences on neuronal function have ...
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Control of Innate Immune Signaling and Membrane Targeting by the Hepatitis C Virus NS3/4A Protease Are Governed by the NS3 Helix α0
... The 9.6-kb single-stranded RNA genome of HCV encodes a single polyprotein that is co- and posttranslationally processed by cellular and viral proteases, including the NS3/4A protease com- plex, into the structural and ...
9
Probabilistic grammatical model for helix‐helix contact site classification
... the helix-helix pair acting as centroid (3D template) in the WDG dataset was selected as class ...processing helix pair sequences of varying lengths introduces an extra level of complexity, which may ...
26
MBAR enhanced lattice Monte Carlo simulation of the effect of helices on membrane protein aggregation
... We study the effect of helical structure on the aggregation of proteins using a simplified lattice protein model with an implicit membrane environment. A recently proposed Monte Carlo approach, which exploits the proven ...
34
Görner, Karin (2006): Strukturelle und funktionelle Untersuchungen des PARK7 Parkinsongenprodukts DJ-1. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Alle Mitglieder der Superfamilie sind in einer multimeren Struktur aktiv. Dabei weisen DJ- 1 und YajL beide eine dimere Quartärstruktur auf. Ein C-terminales Strukturelement, bestehend aus zwei Helices und einem Knick, ...
183
Phylogenetic analysis of the human basic helix loop helix proteins
... The fact that only three mouse genes lack human orthologs strongly argues that, although our analysis was made on a draft version of the human genome sequence, the set of bHLH we retriev[r] ...
18
Investigating helix helix interactions in the transmembrane domains of membrane proteins
... TM helix mediate stronger helix-helix interactions than those at the ends (Johnson, Rath et ...a helix to oligomerise, it has also been found in some cases to play no role in helix- ...
191
Autoimmunogenicity of the helix-loop-helix DNA-binding domain
... canonical helix-loop-helix ...the helix-loop-helix DNA-binding domain as one of the molecular triggers of autoimmunity to DNA and DNA-associated ...
39
The Quintuple Helix innovation model: global warming as a challenge and driver for innovation
... Quintuple Helix innovation model (Carayannis and Campbell 2010) bridges social ecology with knowledge production and ...Quintuple Helix innovation model, the natural- environments-of-society are being ...
12
Wide band RH Circular Polarized Antenna; Design and Analysis
... The data link, mobile satellite, base station, flight termination system and in signal monitoring applications helical antennas are popularly used. Present paper coaxial feed wide band circular polarized helical antenna ...
6
MyoD and the regulation of myogenesis by helix loop helix proteins
... Many members of the HLH protein family, including the MyoD family of myogenic regulatory genes, have a region rich in basic amino acids that is immediately amino-terminal to the HLH doma[r] ...
7
Statistical shape methodology for the analysis of helices
... statistical helix model (similar in spirit to Mardia et ...the helix axis to start the iterations, and there are a large number of methods in the literature such as Rotfit described by Christopher et ...
25
C-Terminal Region of Outer Surface Protein C Binds Borreliacidal Antibodies in Sera from Patients with Lyme Disease
... 5 helix and a small region of the ␣ 4 helix (12), and high concentrations of antibodies specific for regions ( ␣ 1 helix) near the N terminus have been observed in sera from patients with early Lyme ...
6