Transmission disequilibrium
Candidate Gene Analysis for Quantitative Traits Using the Transmission Disequilibrium Test: The Example of the Melanocortin 4-Receptor in Pigs
... linkage disequilibrium can be used to map quantitative trait loci (QTL) with high ...The transmission-disequilibrium test (TDT) is a robust test for detecting ...linkage disequilibrium with ...
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Robust Transmission/Disequilibrium Test for Incomplete Family Genotypes
... Several solutions have been proposed to extend the transmission disequilibrium test (TDT) to include cases with missing parental genotype. However, completion of the missing parental genotype may bias the ...
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Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus
... linkage disequilibrium in this interval was also ...exhibit transmission disequilibrium, with the peak single marker multiallelic linkage disequilibrium noted at D1S490 (pedigree ...
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Comparison of a unified analysis approach for family and unrelated samples with the transmission disequilibrium test to study associations of hypertension in the Framingham Heart Study
... The transmission-disequilibrium test (TDT) makes use of family structure to match the cases and controls on their genetic background and thus avoids ...
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Multiphase analysis by linkage, quantitative transmission disequilibrium, and measured genotype: systolic blood pressure in complex Mexican American pedigrees
... We apply a multiphase strategy for pedigree-based genetic analysis of systolic blood pressure data collected in a longitudinal study of large Mexican American pedigrees. In the first phase, we conduct variance-components ...
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An ordered subset approach to including covariates in the transmission disequilibrium test
... Herein, we introduce two slightly different approaches, inspired by OSA and by Spielman's transmission-disequi- librium test (TDT) [4], for family-based linkage and asso- ciation testing. We apply these approaches ...
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Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway
... candidate genes was rather subjective, it turned out that some of the tested candidate genes are associated with both allergy and vitamin D metabolites. Statistical signif- icance, however, was weak, and varied even with ...
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The ITGAVrs3738919 C allele is associated with rheumatoid arthritis in the European Caucasian population: a family based study
... the transmission disequilibrium test (TDT) was used to detect linkage through preferential transmission of one allele to the affected subjects, and the genotype relative risk (GRR) test was used to ...
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Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family based case–control study
... Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability. JRA is likely to be a complex genetic trait, or a series ...
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Serotonergic System and Attention Deficit Hyperactivity Disorder (ADHD): a potential susceptibility locus at the 5 HT1B receptor gene in 270 Trios from a multi center sample
... mission of the same allele was also seen in the samples from Wales/Manchester and Birmingham but this did not reach statistical significance in either case. How- ever, in the sample from London, the allele 861G was less ...
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Variants of ST8SIA1 are associated with risk of developing multiple sclerosis
... Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system of unknown etiology with both genetic and environmental factors playing a role in susceptibility. To date, the HLA DR15/DQ6 ...
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Haplotype phasing after joint estimation of recombination and linkage disequilibrium in breeding populations
... frequencies for two alleles). In reality, SNP polymorphisms are arranged in aligned sequences forming haplotypes where the order of the alleles for consecutive SNPs within each homologue chromosome contains relevant ...
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Correct or incorrect application of CAPM? Correct or incorrect decisions with CAPM?
... It shows that i CAPM capital budgeting decision-making based on disequilibrium NPV is deductively inferred by the Capital Asset Pricing Model, ii the use of the disequilibrium NPV is wid[r] ...
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Modeling Extent and Distribution of Zygotic Disequilibrium: Implications for a Multigenerational Canine Pedigree
... Hardy–Weinberg disequilibrium (HWD), zygotic disequilibria that have power to characterize nonrandom associations at both gametic and zygotic levels (W eir 1996) may be more ...
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Homozygosity and Linkage Disequilibrium
... linkage disequilibrium and systematic data are collected (Kidd et ...of disequilibrium ceived a great deal of ...example, disequilibrium between markers was used to one needs to refer to a “map” of ...
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Region-based interaction detection in genome-wide case-control studies
... Current interaction detection methods are mainly based on the deviation from additive effect by assuming a linear or logistic regression model. Nevertheless, this approach is not necessarily the most powerful method due ...
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Theory and applications of disequilibrium econometrics
... subsequent disequilibrium econometric models have evolved, is that by Fair and Jaffee (1972), although the origins of many of the techniques they discuss may be traced back to Page (1955, 1957), Quandt (1958, ...
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A Genealogical Interpretation of Linkage Disequilibrium
... the result of a single mutation [single-nucleotide poly- pected probability that two alleles drawn with replace- morphisms (SNPs)]. When there are just two alleles at ment will be different at the x locus and another two ...
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Linkage Disequilibrium in the Domesticated Pig
... linkage disequilibrium to variation in linkage ...Gametic disequilibrium measures: proceed Testing for the presence of previously identified QTL for milk with ...Gametic disequilibrium and ...
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Cosmopolitan linkage disequilibrium maps
... linkage disequilibrium (LD) and maps of single nucleotide polymorphisms (SNPs), it is of interest to consider a standard LD map which is somewhat analogous to the corresponding map for ...
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