Transplantation tolerance
Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby
... of transplantation for the treatment of end-stage organ ...of transplantation tolerance, they share the propensity to provoke chronic, incomplete activation of T ...dominant tolerance to male ...
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Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice
... immunosuppression. Further, although dTregs were only slightly less effective than TCR- transduced Tregs at inducing long-term survival of fully MHC-mismatched heart grafts, histologic analysis of long-surviving hearts ...
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Tregs and transplantation tolerance
... create transplantation tolerance ...after transplantation). In the case of central tolerance, this alone appears to be sufficient, as newly developing T cells with potential anti-donor ...
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Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice
... organ transplantation is how to establish indefinite graft survival that is free from long-term treatment with immunosuppressive drugs and chronic rejection ...induce tolerance to transplanted hearts in ...
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Virus-Induced Abrogation of Transplantation Tolerance Induced by Donor-Specific Transfusion and Anti-CD154 Antibody
... disrupt tolerance to the ...after tolerance induction and transplantation had minimal effect on subsequent allograft ...during tolerance induction and transplantation killed graft ...
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The status of transplantation tolerance between chimeric twin calves
... xv 2.13 Changes in the proportion of Blast Cells in the Total Efferent Lymphocyte Population from the Prefemoral Lymph Node of 5 Chimeric Calves in receipt of Cotwin Skingrafts.. 122 3.1[r] ...
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Heterologous immunity provides a potent barrier to transplantation tolerance
... experiments, tolerance was induced in 37 of 45 LCMV- immune mice (82%), which is lower than the over 95% tol- erance induction rate in naive mice, as observed in well over 200 nonconcurrent control recipients, ...
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Harnessing FOXP3+ regulatory T cells for transplantation tolerance
... ensuring tolerance to self-antigens, while pTregs operate to moderate responses to certain “foreign” antigens that might be found in the gut microbiome or in the fetus during pregnancy ...for tolerance ...
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Challenges to achieving clinical transplantation tolerance
... in transplantation, as well as being found in many human diseases, in which their functions remain to be ...of tolerance will require extensive investigation, since their prime action may occur in ...
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CD28 ligation induces transplantation tolerance by IFN γ–dependent depletion of T cells that recognize alloantigens
... peripheral tolerance did not occur in CD28 KO pregnant mice in contrast to the partial clonal deletion and hyporesponsive- ness of remaining T cells observed in CD28 WT pregnant mice ...
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Do maternal cells trigger or perpetuate autoimmune diseases in children?
... How do MHC alleles affect MMc and autoimmunity? MMc is often found in healthy individuals. Therefore, if MMc has the potential to become pathogenic, additional environmental or genetic factors must be involved. The case ...
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The Need for Tolerance in Pediatric Organ Transplantation
... however, transplantation does not re- store patients to a normal life, because they are left on lifelong immunosuppression with its associated compli- ...of transplantation tolerance—the specific ...
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Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation
... Transplanted individuals in operational tolerance (OT) maintain long-term stable graft function after completely stopping im- munosuppression. Understanding the mechanisms involved in OT can provide valuable ...
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Comparing glycaemic benefits of Active Versus passive lifestyle Intervention in kidney Allograft Recipients (CAVIAR): study protocol for a randomised controlled trial
... kidney transplantation is dif- ferent from the general population due to immunosup- pressant side effects, weight gain and fatigue being more common post ...
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Original Article Bone marrow transplantation reverses new-onset immunoinflammatory diabetes in a mouse model
... blood glucose of diabetic mice irradiated at similar dose followed by low-dose BMCs infu- sion increased rapidly after a transient delay [10]. The hematopoiesis recovery time after moderate dose TBI (5Gy) followed by ...
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Original Article IL-35 induces immune tolerance in renal transplantation rats by modulating CD4+CD25+ regulatory T-cells
... immune tolerance in renal transplantation rats by modulating CD4+CD25+ regulatory ...renal transplantation rats, as well as expression of IL-6, IL-17, and ...immune tolerance by targeting ...
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Intra graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation
... The transcriptional profiles of liver tissue samples from operationally toler- ant and non-tolerant recipients differ from those observed before the initia- tion of drug minimization in PBMCs. Our group previously ...
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Original Article Adenovirus-mediated IL-10 transfection induces immune tolerance in corneal transplantation
... immune tolerance, mainly through promoting Th2 cell differentiation, inhibiting proliferation of Th1 cells, and reduc- ing Th1 cells to secrete IL-2 and IFN-γ [22, ...corneal transplantation in rabbits, ...
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Gut microbiota and allogeneic transplantation
... liver transplantation had remarkably reduced numbers of Bifidobacterium and Lactobacillus, whereas Enterococcus and Enterobac- teria were significantly increased ...
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Current role in facial allograft transplantation: what have we learned?
... From the first FT performed a decade ago, more than thirty FAT have been performed worldwide with promising immunological, functional, psychological and aesthetic results that have clearly demonstrated the feasibility of ...
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