treat to target
Treat to target in PsA: methods and necessity
... a treat- to- target approach in ...a treat- to- target approach in PsA and have offered specific advice on how to do this using outcomes such as the minimal disease activity ...of ...
5
The rheumatoid arthritis treat to target trial: a cluster randomized trial within the Corrona rheumatology network
... There is a growing consensus that rheumatologists should measure patient disease activity using validated composite clinical measures and then accelerate treat- ment until the disease is in remission, an approach ...
7
Cost-effectiveness of different treat-to-target strategies in rheumatoid arthritis: results from the DREAM registry
... The approach currently recommended for RA treatment involves titrating medication dosages until pre-specified disease activity targets (either remission and low disease activity (LDA) or LDA) have been met and ...
9
Novel optical spectral transmission (OST) guided versus conventionally disease activity guided treatment: study protocol of a randomized clinical trial on guidance of a treat to target strategy for early rheumatoid arthritis
... and treat-to-target treatment strat- egies for the treatment of RA, typically frequent disease activity assessment is applied using the Disease Activity Score (DAS), a composite score of an acute phase ...
10
Characterising deviation from treat to target strategies for early rheumatoid arthritis: the first three years
... ACR: American college of rheumatology; anti-CCP: anti-cyclic citrullinated peptide; BMI: body mass index; CRP: C-reactive protein; DAS28: disease activity score in 28 joints; DMARDs: disease-modifying anti-rheumatic ...
14
Adherence to a treat to target strategy in early rheumatoid arthritis: results of the DREAM remission induction cohort
... ACR: American College of Rheumatology; Anti-CCP: anti-cyclic citrullinated peptide; Anti-TNF: anti-tumor necrosis factor; CRP: C-reactive protein; DAS28: Disease Activity Score in 28 joints; DMARDs: disease-modifying ...
9
Trajectory of intensive treat-to-target disease modifying drug regimen in an observational study of an early rheumatoid arthritis cohort
... a treat-to-target combin- ation DMARD algorithm is likely to be effective over the ensuing months in patients who make a moderate response by week ...
10
Management of chronic spontaneous urticaria (CSU): a treat to target approach using a patient reported outcome
... Chronic spontaneous urticaria is similar in many aspects to chronic diseases for which a T2T approach has been established. A validated clinical activity tool, the Urticaria Activity Score 7 (UAS7), allows clinicians to ...
7
Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: A sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients
... HbA1c, suggesting a general intra class difference in the potential for improving the metabolic abnormalities present in patients with the metabolic syndrome [15]. It was therefore the aim of the present analysis of the ...
11
Testing Treat-to-Target Outcomes With Initial Methotrexate Monotherapy Compared With Initial Tumor Necrosis Factor Inhibitor (Adalimumab) Plus Methotrexate in Early Rheumatoid Arthritis
... the treat-to-target strategy allows for a good outcome without the need for a bDMARD, despite negative prognostic factors, and prevents overtreatment of one in four patients with active ...
5
Efficacy and cost-effectiveness of nurse-led care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial
... between-group difer ences. Second, blinding of the intervention was not possible, which might have afected the behaviour of GPs and participants in the usual-care group (eg, GPs more actively managing the gout of ...
11
Use of a multidisciplinary tool to achieve target outcomes in Native American patients with diabetes: Treat-to-target
... one-page Treat-to-Target form to recommend opportunities for improvement in disease state of which the patient was not meeting evidence-based ...the Treat-to-Target tool would be circled, ...
6
Does Treat to Target strategy compared to usual care reduce long term structural joint damage in rheumatoid arthritis?
... An important gap in our knowledge concerns the effects of early interventions on long-term (>5 years) structural joint damage in patients with rheumatoid arthritis (RA) (1,2). The prognosis of RA has improved in the ...
35
Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat to target escalation of therapy in rheumatoid arthritis
... radioulnar joint; FS: Fat saturation; GdDTPA: Gadolinium diethylenetriamine pentaacetic acid; ICC (av): Intraclass correlation coefficient (average); MC: Metacarpal; MRI(i): Total MRI inflammation score at the wrist (sum ...
9
Treat-to-target strategies in pulmonary arterial hypertension: the importance of using multiple goals
... any treat-to-target ...early treat- ment that improves cardiac haemodynamics may protect the right heart during the progressive phase of vascular remodel- ling or even prevent malicious irreversible ...
7
Interferon-alpha-based immunotherapies in the treatment of B cell-derived hematologic neoplasms in today’s treat-to-target era
... The addition of IFN-α was reported to augment ADCC by therapeutic mAbs both in vitro and in vivo [49, 50]. Specifically, mAb-mediated ADCC can be enhanced by IFN-α in the 3 ways: (1) enhancement of total tar- ...
9
Impact of a magnetic resonance imaging guided treat to target strategy on disease activity and progression in patients with rheumatoid arthritis (the IMAGINE RA trial): study protocol for a randomized controlled trial
... The AMBRA study at King Christian 10th Hospital for Rheumatic Diseases, Graasten and Vejle Hospital, in- volved 300 patients with RA in accordance with the ACR 1987 classification criteria, DAS28 < 3.2, ≥1½ year’s ...
11
The role of anti citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat to target therapy
... intensive treat- ment strategies have altered the disease course of early RA, and consequently established predictors for treat- ment response and progression of radiographic damage should be re-evaluated ...
11
Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug free remission after initiating treat to target tocilizumab, methotrexate, or the combination: insights from systems biology
... the target of sustained remission, defined as disease activity score assessing 28 joints (DAS28) < ...the treat- ment target was achieved, medication was tapered step- wise and finally ...
11
Factors influencing use of biologic therapy and adoption of treat-to-target recommendations in current European rheumatology practice
... no target (patients treated without a T2T approach), pragmatic (T2T target set as LDA or something other than remission), or aspirational (T2T goal set as ...
8