Trichostatin A
Trichostatin A enhances acetylation as well as protein stability of ERα through induction of p300 protein
... Figure 1 Trichostatin A enhances acetylation as well as stability of ERα protein. (a) T47D cells were treated with or without 1 μM trichostatin A (TSA) for 1 hour. Then 500 μg whole-cell lysate was ...
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The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and rapid upregulation of gadd45β in LS174T human colon cancer cells
... Histone deacetylase (HDAC) inhibitors are consid- ered as promising therapeutic agents against several malignant diseases because they inhibit cancer cell proliferation. The stress sensor genes of the growth arrest and ...
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Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury
... Trichostatin A is neuroprotective in females only after neonatal lipopolysaccharide-sensitised hypoxia-ischaemia Our data are in general agreement with those reported pre- viously that HDACis are neuroprotective ...
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Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy
... mg/kg trichostatin A (TSA) in nontransgenic and SMA model mice resulted in increased levels of acetylated H3 and H4 histones and modest increases in SMN gene ...
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The effect of trichostatin-A and tumor necrosis factor on expression of splice variants of the MaxiK and L-type channels in human myometrium
... The onset of human parturition is associated with up-regulation of pro-inflammatory cytokines including tumor necrosis factor (TNF) as well as changes in ion flux, principally Ca 2+ and K + , across the myometrial ...
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Original Article Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer
... of trichostatin A (TSA) on gastric cancer cell line BGC-823, and identify the differentially expressed genes induced by TSA, which might participate in the progression of gastric ...
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Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway
... Abstract: Histone acetylation enzyme inhibitor is a kind of high-efficiency and low toxicity drug for cancer. Therefore, as histone acetylation enzyme inhibitor, it is very important to explore the mechanism of ...
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Trichostatin A Up-Regulates Human Papillomavirus Type 11 Upstream Regulatory Region-E6 Promoter Activity in Undifferentiated Primary Human Keratinocytes
... that trichostatin A, a specific inhibitor of histone deacetylase, dramatically stimulated reporter gene activity from the wild-type HPV-11 URR or the C/EBP mutation in PHKs grown in undifferentiated submerged ...
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Combination of azacitidine and trichostatin A decreased the tumorigenic potential of lung cancer cells
... The cross-talk among different epigenetic activities provides the basis for using a combination of epigenetic agents. In this report, we determined the optimal dosages of DNMT- and HDAC-inhibitors, azacitidine (5-AZA) ...
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Effect of Curcumin and Trichostatin A on the Expression of DNA Methyltransfrase 1 in Hepatocellular Carcinoma Cell Line Hepa 1-6
... Background: Hepatocellular carcinoma (HCC), primary liver cancer, is a major health problem and the third most common cause of cancer-related deaths worldwide. Epigenetic modulations are essential for the maintenance of ...
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Reactivation of the Human Cytomegalovirus Major Immediate-Early Regulatory Region and Viral Replication in Embryonal NTera2 Cells: Role of Trichostatin A, Retinoic Acid, and Deletion of the 21-Base-Pair Repeats and Modulator
... Inactivity of the human cytomegalovirus (HCMV) major immediate-early regulatory region (MIERR), which is composed of promoter, enhancer, unique region, and modulator, is linked to lack of HCMV replication in latently ...
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Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells
... The aim of this study was to determine whether alterations in the localization of HP1 proteins induced by trichostatin A (TSA) modify Mis12 and Centromere Protein A (CENP-A) recruitment [r] ...
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Protective effect of leptin on induced apoptosis with trichostatin A on buffalo oocytes
... Leptin, the 16-kDa product of the obese (ob) gene, primarily secreted from adipose tissue, has been implicated to play an important role in the regulation of food intake and energy expenditure. This study investigated ...
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Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3)
... Conclusion: This study is the first to report that the combination of rGO-Ag and TSA can cause potential cytotoxicity and also induce significantly greater cell death compared to either rGO-Ag alone or TSA alone in SKOV3 ...
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Trichostatin A promotes GLI1 degradation and P21 expression in multiple myeloma cells
... Methods: In the present study, RPMI8226 and MM.1S cells treated with TSA were used for cell proliferation, cell cycle, and survival examinations, then the localization and post transcr[r] ...
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Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation
... Results: Nuclear HDAC activity and class I HDAC expression were significantly higher in MG63 cells than in hFOB 1.19 cells, and a similar trend was observed in the human osteosarcoma t[r] ...
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PubMedCentral-PMC5010799.pdf
... neurodevelopment. We investigated the effects of adolescent intermittent ethanol (AIE) exposure, as opposed to normal saline (AIS) exposure, on histone acetylation-mediated regulation of brain- derived neurotrophic ...
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The Silencing of RECK Gene is Associated with Promoter Hypermethylation and Poor Survival in Hepatocellular Carcinoma
... The molecular mechanisms behind RECK tran- scriptional regulation are clearly complex, and are still yet to be fully defined. So far the few studies con- ducted focused on RECK methylation and no data are available ...
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Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells
... HDACs enzymes remove acetyl groups from histones and suppress gene transcription. Recent studies have shown that HDAC inhibitors also have immune- modulatory properties, such as increasing expression of HLA-DR, ICAM-1 ...
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Comparative Analysis of the Effects of Valproic Acid and Tamoxifen on Proliferation, and Apoptosis of Human Hepatocellular Carcinoma WCH 17 CellLin
... cancer (36). One of the mechanism of apoptotic induction of TAM is caspase-3- like proteases activity induction and c-Jun NH2-terminal kinase (JNK) 1 activation which has been reported in MDA-MB-231 and BT-20 cell line ...
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