Trk receptors
Modulation of neurotrophic signaling pathways by polyphenols
... (Trk) receptors, the main receptors of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) explains the action of few polyphenols such as ...
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The Role of Brain-Derived Neurotrophic Factor in the Pathophysiology of Psychiatric and Neurological Disorders
... to Trk receptors was found increased in the post-mortem brain of suicide subjects ...decreased Trk signaling and increased p75NTR, may indicate a shift from cell survival that could be associated ...
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The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells
... Degenerate oligonucleotides corresponding to sequences GDFGMSR and WMPPESI were designed based on conserved regions within the tyrosine kinase domain of vertebrate Trk receptors. PCR reactions (50 µ l) were ...
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Evaluation of Tyrosine Kinase receptor (TrK) Expression in Follicular and Plexiform types of Ameloblastoma: An Immunohistochemical study
... of Trk-kinase receptors by their cognate ligands initiates a cascade of signaling events which leads to either mitogenic stimuli for malignant transformation or neuronal ...differentiation. Trk ...
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Trk Family Neurotrophin Receptors and p75 Receptor A Multiple Competing Hypothesis Case in the Nerve Growth Factor (NGF) History
... neurotrophin receptors set. The discovery that in cells expressing Trk receptors, neurotrophins promote cell survival changed everything previously knew about ...
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Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development
... (C-F) Trk receptor signaling is necessary for appropriate embryonic ...(G-I) Trk receptors collaborate to regulate precursor proliferation and ...
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Regulation and Kinase Activity of the Trk Family of Receptor Tyrosine Kinases
... the Trk tyrosine kinase domain (TKD). The Trk TKDs are members of the insulin receptor kinase (IRK) superfamily and recent data suggest that the IRK family displays a wide array of autoinhibitory ...the ...
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Developmental potential of defined neural progenitors derived from mouse embryonic stem cells
... of Trk receptors is detected in chick cells in the DRG (arrow), and in their axons (arrowhead) projecting to the spinal cord, but not in GFP+ donor ...
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Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma
... binding Trk subtypes A, B and C, or binding neurotrophin receptor p75NTR, a member of the tumor necrosis factor receptor superfamily ...[24]. Trk receptors have been identified as prognostic factors ...
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Insights into Current Tropomyosin Receptor Kinase (TRK) inhibitors: development and clinical application
... Cabozantinib (23, COMETRIQ®) is a pan-kinase inhibitor developed by Exelixis with FDA approval to treat metastatic medullary thyroid cancer (mMTC) and renal cell carcinoma (RCC). Cabozantinib was first approved to treat ...
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Expression of brain-derived neurotrophic factor in kidneys from normal and cyclosporine-treated rats
... and Trk receptors are expressed in a wide range of nonneuronal ...and Trk receptors in the ...and Trk receptors (TrkB and TrkC) are expressed in the proximal and dis- tal tubules ...
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Role of Nerve Growth Factor (NGF) and Its Receptor Tyrosine Kinase A (TrK A) in Egyptian Cirrhotic Patients with Pruritus
... and receptors are ...receptor TrK A has a role in pruritus in a group of Egyptian cirrhotic pa- ...between TrK A protein expression and severity of pruri- tus in cirrhotic patients with pruritus (r = ...
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The effect of 3,4- methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats
... could be due to the fact that in the current study, the exam- ination of MDMA neurotoxicity was performed at time points different from those of Hammerle et al. study. Moreover, the results of the present study showed ...
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More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells
... It was demonstrated BDNF/TrkB protected various tumor cells from apoptosis [24]. To investigate a positive role of BDNF/TrkB in HCC cell survival, apoptosis was examined after anti-BDNF or K252a treatment using Annexin ...
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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
... Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. Correlations ...
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Incomplete Penetrance and Variable Expressivity of a Growth Defect as a Consequence of Knocking Out Two K+ Transporters in the Euascomycete Fungus Podospora anserina
... Increasing the temperature resulted in the destabili- of transporters and exhibits several differences in its zation of the growth alteration. The normal form of transport properties when compared withTRK-1 (Haro et ...
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Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
... To identify novel ITRs which may enhance the clinical re- sponse to RA when given as combination therapies, we next collated ITRs which were strongly differentially regulated between the three conditions (Fig. 4d). One ...
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Expression of HIV receptors, alternate receptors and co receptors on tonsillar epithelium: implications for HIV binding and primary oral infection
... HIV receptors, co-receptors, surface adhesion molecules and alternate receptors in stratified squamous epithelium and cryptal reticulated epithelium that individually or collectively could support ...
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Importance of innate mucosal immunity and the promises it holds
... Abstract: The body defense mechanism has evolved to protect animals from invading pathogenic microorganisms and cancer. It is able to generate a diverse variety of cells and molecules capable of specifically recognizing ...
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Identification and Expression Analysis of Putative Chemosensory Receptor Genes in Microplitis mediator by Antennal Transcriptome Screening
... In the present study, we focused on three crucial families of chemosensory receptor (ORs, GRs and IRs) due to their significance as potential target genes for manipulating parasitoid wasps in order to improve biological ...
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