tRNA synthetase
A MUTANT OF YEAST WITH A DEFECTIVE METHIONYL-tRNA SYNTHETASE
... In forty-five of the forty-seven tetrads from hybrid HI9 le- : le+ segregated 2 : 2 and the ts- 296 mutation (methionyl-tRNA synthetase) displayed a second division segr[r] ...
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A human leucyl-tRNA synthetase as an anticancer target
... Abstract: Several aminoacyl-tRNA synthetases have been reported to be overexpressed for charging essential aminoacyl-tRNAs in many cancer types. In this study, we aimed to explore the potential role of ...
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Valyl-tRNA synthetase modification-dependent restriction of bacteriophage T4.
... Under these modified conditions, valyl-tRNA synthetase from T4vs+-infected CP 790302 90.6 ,umol/min per ,ug of protein exhibited approximately a two-thirds reduction in specific activity[r] ...
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N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors
... of tRNA is a two-step process in which the enzymes initially form an aminoacyl adenylate intermediate from the amino acid and ...isoleucyl-tRNA synthetase (IleRS) inhibitor, mupirocin, 5-7 also known ...
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Incorporation of Lysyl-tRNA Synthetase into Human Immunodeficiency Virus Type 1
... LysRS in the cytoplasm and intermediate LysRS in the viruses (particularly in viruses produced from human cell lines) sug- gests that the intermediate and small LysRS species may be generated by proteolysis of the large ...
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Cysteine Activation in Cultured Cystinotic Cells THE SPECIFIC ACTIVITY OF CYSTEINYL tRNA SYNTHETASE AND tRNACys AND THE DETERMINATION OF THE MICHAELISMENTEN CONSTANTS FOR CYSTEINYL tRNA SYNTHETASE
... cysteinyl-tRNA synthetase might lead to the faulty regulation of cyst(e)ine levels in cystinotic ...cysteinyl- tRNA levels, cysteinyl-tRNA synthetase activity, and the K m of cysteine, ...
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Alanyl tRNA Synthetase Quality Control Prevents Global Dysregulation of the Escherichia coli Proteome
... Despite the importance for AlaRS proofreading and the presumed negative impact on proteome homeostasis of Ala mistranslation events, evidence for beneficial mis- translation has also recently been observed. During ...
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IN SILICO SCREENING OF FLAVONOLS AGAINST BRUGIA MALAYI ASPARAGINYL tRNA SYNTHETASE
... biological benefits to human health that include not only anti-inflammatory, antioxidant, antibacterial, antifungal and antiviral activities but also anti filarial activity 12 . Numerous studies have successfully shown ...
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Reaction of anti OJ autoantibodies with components of the multi enzyme complex of aminoacyl tRNA synthetases in addition to isoleucyl tRNA synthetase
... isoleucyl-tRNA synthetase (recognized by anti-OJ autoantibodies), is a component of the multi-enzyme complex containing at least seven ...isoleucyl-tRNA synthetase enzyme ...leucyl-tRNA ...
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Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination
... Regarding the selective vulnerability of nervous system tracts in LBSL, analysis of intron 2 splice site mutations showed that the correct inclusion of exon 3 in the normal aspartyl-tRNA synthetase ...
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Cytoplasmic leucyl-tRNA synthetase of Neurospora crassa is not specified by the leu-5 locus.
... We generated a Xgtl 1 Neurospora crassa cDNA library and screened the library for the cytoplasmic leucyl-tRNA synthetase (cyto LeuRS) clones using cyto LeuRS specific antib[r] ...
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Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes
... (A) Schematic representation of the KARS gene and the distribution of published mutations (black, above) and mutations found in our patient cohort (red, below). (B) Ribbon diagram of the complex structure model of human ...
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Human tryptophanyl tRNA synthetase is an IFN γ–inducible entry factor for Enterovirus
... which is an important global cause of hand, foot, and mouth disease and life-threatening encephalitis. We identified an IFN-γ–inducible EV-A71 cellular entry factor, human tryptophanyl-tRNA synthetase ...
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Temporal appearance of bacteriophage T4-modified valyl tRNA synthetase in Escherichia coli.
... Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Bacteriophage T4-induced modification of Escherichia coli valyl-tRNA synthetase EC 6.1.1.9 requires: synthesis of a phag[r] ...
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Viral Hijacking of Mitochondrial Lysyl-tRNA Synthetase
... multi-aminoacyl-tRNA synthetase complex iso- lated from rabbit liver could be revealed only with anti-cKRS antibodies ...multi-aminoacyl-tRNA synthetase complex purified from rabbit containing ...
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Plant perception of beta-aminobutyric acid is mediated by an aspartyl-tRNA synthetase
... This response is strongly augmented by R-BABA, which blocks the L-Asp binding site of the enzyme, thereby depriving the protein from AspRS activity and priming it for defence activity Fi[r] ...
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Association of DARS gene polymorphisms with the risk of isolated ventricular septal defects in the Chinese Han population
... DARS (MIM 603084, RefSeq accession number NM_001349.2) encodes an aspartyl-tRNA synthetase (AspRS) [20]. Mutations in this gene have been found in patients who exhibit hypomyelination with brainstem and ...
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Chemokine receptors on dendritic cells promote autoimmune reactions
... seryl tRNA synthetase (SerRS), lysyl tRNA syn- thetase (LysRS), and aspartyl tRNA synthetase (AspRS) were not chemotactic for ...the synthetase to have chemotactic effects on ...
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Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei
... valyl-tRNA synthetase (ValRS) (class Ia), tryptophanyl-tRNA synthetase (TrpRS-1) (class Ib), arginyl-tRNA synthetase (ArgRS) (class Ic), glutamyl-tRNA synthetase ...
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In-silico Designing, Synthesis, SAR and Microbiological Evaluation of Novel Amide Derivatives of 2-(3-methylbenzo[b]thiophen-6-yl)-1- (3-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylic Acid
... There has been a continual battle between humans and the multitude of microorganisms that cause infection and disease. Infectious diseases are responsible for great num- ber of deaths in the world population. The ...
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