Trophoblast differentiation
Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation
... during trophoblast differentiation reflects selective expansion of accessible chromatin ...of trophoblast cell migration Ovol2 26 , Tfap2c known to govern trophoblast ...
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Original Article Upregulation of microRNA-155 inhibits trophoblast differentiation through the Wnt/β-catenin pathway
... on trophoblast differentiation, tro- phoblasts of patients with PE were used and results showed that miR-155 was significantly increased while its potential target CACNA2D1 was significantly ...human ...
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Function of caspase-14 in trophoblast differentiation
... Interestingly, the transcription of the genes examined in this study appears to be more sensitive to the suppression of caspase-14 than their subsequent proteins (Figs 3, 4). While this may be indicative of the natural ...
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BMP4 directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state
... the trophoblast, which is derived from extra-embryonic ...early trophoblast differentiation in the human embryo, owing to lack of a proper in vitro model ...functional trophoblast following ...
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Trophoblast Differentiation of Human Embryonic Stem Cells.
... human trophoblast tissues remain poorly characterized in terms of marker proteins, due to the restricted availability of these ...human trophoblast are known ...All trophoblast tissues also express ...
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SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion
... terminal differentiation of primary chorionic gonad- otropin (CG)-secreting ...equine trophoblast cells or placental tissues were isolated from day 27–34 equine ...girdle trophoblast showed increased ...
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Role of mammalian target of rapamycin (mTOR) signalling in BeWo trophoblast differentiation and fusion
... growth. Trophoblast differentiation into a multinucleate syncytium is a key biological ...of trophoblast fusion. The precise role of mTOR in the trophoblast differentiation mechanisms ...
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Trophoblast differentiation during embryo implantation and formation of the maternal fetal interface
... as trophoblast stem cells are derived by plating disaggregated extraembryonic cells on mouse embryonic fibro- blasts in the presence of FGF4, which binds Fgfr2 IIIc, ultimate- ly leading to MAPK signaling ...human ...
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Hypoxia inducible factor 1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3
... of trophoblast cells to increased oxygen ...prevent trophoblast differentiation toward an invasive ...triggered trophoblast proliferation, fibronectin synthesis, a 5 integrin expression, and ...
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Periconceptional alcohol exposure causes female specific perturbations to trophoblast differentiation and placental formation in the rat
... mouse trophoblast stem cells showed downregulation of the expression of mature trophoblast lineage markers at day 6 of differentiation (Kalisch-Smith et ...of differentiation and showed no ...
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Trophoblast differentiation, invasion and hormone secretion in a three-dimensional in vitro implantation model with rhesus monkey embryos
... A central feature to developing an in vitro model of em- bryo implantation is creating a microenvironment that supports development similar to that observed in vivo. Three-dimensional culture systems may create a better ...
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Original Article Expression of uPAR in human trophoblast and its role in trophoblast invasion
... Placental trophoblast cells differentiate into invasive trophoblasts or ...in trophoblast differentiation are ...for trophoblast migration and invasion in explants culture and HTR8/SVneo ...
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Human Cytomegalovirus Infection Interferes with the Maintenance and Differentiation of Trophoblast Progenitor Cells of the Human Placenta
... and differentiation capacity were rescued by anti-gB MAb treatment ...on trophoblast proliferation and early stage differentiation, which are required for continuous growth of the placenta throughout ...
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11ß HSD2 dependent and independent signalling pathways in trophoblast biology and glucocorticoid responsiveness
... of trophoblast apoptosis and disturbances of trophoblast differentiation found in pregnancy-related ...apoptosis, differentiation, endocrine capacity and the expression of molecules involved ...
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Impact of DNA methylation on trophoblast function
... lous trophoblast; since its presence is lacking in andro- genic hydatidiform moles, its expression is thought to be imprinted as well ...syncytio- trophoblast differentiation; its human analogue, ...
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Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation
... controlling trophoblast differentiation during placenta ...during differentiation of TSCs (− ...the differentiation in TSCs and the fusion in BeWo cells [15, ...
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Trisomy 21 affected placentas highlight prerequisite factors for human trophoblast fusion and differentiation
... human trophoblast differentia- tion pathway and is a multifactorial and dynamic process finely regulated and still poorly ...inhibiting trophoblast fusion and differentiation and emphasize the role ...
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Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high and low quality human embryos
... Methodology/Principal Findings: Monolayers of decidualized H-EnSCs were generated from endometrial biopsies of 6 women with RM and 6 fertile controls. Cell-free migration zones were created and the effect of the presence ...
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Aberrantly Up-regulated miR-20a in Pre-eclampsic Placenta Compromised the Proliferative and Invasive Behaviors of Trophoblast Cells by Targeting Forkhead Box Protein A1
... As microRNAs take effects by fine-tuning the expression of target proteins, we bioinformatically analyzed the potential targets of miR-20a to explore the mechanism underlying its effects on trophoblast cell ...
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Trophoblast-uterine interactions at implantation
... Endocrine mediators other than E and P also play a role. Endometrial cells express the androgen receptor AR [66]), the luteinising hormone receptor LHR[67], the gonado- trophin-releasing hormone receptor [68], the ...
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