TRPV1 and Disease
Transient receptor potential Vanilloid 1 (TRPV1) in haematological malignancies
... of TRPV1 by CAP, which may have a role in the up- or down- regulation of TRPV1 expression (Akbar et ...a TRPV1 monomer (~95kDa) was detected in four B-NHL and one MM ...a TRPV1 band at ~240kDa ...
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Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity
... skin disease and cancer can cause toxicity and produce sensory hypersensitivity associated with burning, pruritus, and inflammation in humans when applied topically or systemically (6–8, ...initiating TRPV1 ...
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TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis
... of TRPV1 had no detectable impact on disease-promoting autoimmune profiles, including numeric, functional and subset distributions of autoreactive lymphocyte ...lineages. TRPV1 may be expressed on ...
11
TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder
... The TRPV1 receptor may have two synergistic roles in mediating bladder mechano- ...and TRPV1 immunoreactive nerves increases in disease 28,33 and is significantly reduced following successful ...
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Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough
... Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, ...
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TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder
... The TRPV1 receptor may have two synergistic roles in mediating bladder mechano- ...and TRPV1 immunoreactive nerves increases in disease 28,33 and is significantly reduced following successful ...
11
Cannabinoid based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis
... Furthermore, the FAAH substrates OEA and PEA can support anti-inflammatory and neurogenic effects of central CB 1 activation via peroxisome-proliferator acti- vated receptors. In addition, CB 1 activation in the brain ...
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Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
... the TRPV1 receptor in cardiac pathologies, including coronary heart disease, myocardial infarction, heart failure, and ...neuronal TRPV1 activation seems to play a crucial role in reducing ...
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Pain control through selective chemo axotomy of centrally projecting TRPV1+ sensory neurons
... primary disease 5 weeks after RTX injection, at which time lumbar, thoracic, and cervical ganglia and spinal cord samples were removed and stored at –80°C until RNA extraction or immersion fixation in ...
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Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis
... to different levels of pain that patients experience, the use of analgetic drugs and different pain scales. Moreover, there are several confounding variables, such as depend- ence of analgetic drugs and the use of ...
7
Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression
... inducible TRPV1 overexpression and assessed the role of TRPV1 levels on cell death mediated by the TRPV1 activator capsaicin and the potential for submaximal activation to promote ...The TRPV1 ...
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Activation of TRPV1 by Capsaicin Regulates ENaC
... and TRPV1 activators capsaicin (CAP), resiniferatoxin (RTX), and elevated temperature (>38C) induced biphasic effect on the chorda tympani (CT) taste nerve responses ...that TRPV1 agonists modulated the ...
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Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: mechanosensitive TRPV1 as an “acupuncture responding channel”
... 8% SDS-Tris glycine gel electrophoresis and transferred to a PVDF membrane. The membrane was blocked with 5% nonfat milk in TBS-T buffer (10 mM Tris pH 7.5, 100 mM NaCl, and 0.1% Tween-20) and incubated with the ...
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Expression and functionality of TRPV1 in breast cancer cells
... of TRPV1, a nonselective cation channel that was found to be expressed in different carcinoma ...of TRPV1 in several native breast cancer tissues, which was subsequently validated via reverse ...
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Effect of SQW on the bladder function of mice lacking TRPV1
... a TRPV1 KO mice model ...lacking TRPV1 receptor inhibited increased frequency of urination and increased frequency of low-amplitude con- tractions in such animals ...of TRPV1 receptors in the mic- ...
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Quinoline as TRPV1 Antagonists: A New Approach against Inflammation
... The TRPV1 receptor, first cloned and characterized in 1997, is a non- selective cation channel expressed in primary sensory neurons, and is a key pain sensor and ...
7
Ethanol Potentiates The TRPV1-Mediated Cough In The Guinea Pig
... potentiates TRPV1-mediated cough by a PKC-dependent mechanism in a guinea pig ...affect TRPV1 seems to derive from its property to sensitize the channel to other ...for TRPV1 activation by 8°C ...for ...
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Transient receptor potential Vanilloid 1 (TRPV1) in haematological malignancies
... In Chapter 2, the effect of CAP on the metabolic activity of three malignant haematological cell lines, THP-1, U266B1 and U937, was investigated. Metabolic activity assays were performed using the alamarBlue ® method. ...
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TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity
... AA-3’; TRPV1 forward: 5’-AAG GCT CTA TGA TCG CAG GA-3’; TRPV1 reverse: 5’-CAG ATT GAG CAT GGC TTT GA-3’; GAPDH forward: 5’-AGG TCA TCC AGC TGA ACG-3’; GAPDH reverse: 5’-CAC CCT GTT GCT GTA GCC GTA ...
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The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating
... with the fast kinetics of temperature-induced gating, the lower threshold of activation, and the smaller Q 10 value of channel gating at depolarized potentials, as well as with the lack of voltage dependency of the T 0.5 ...
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