TRPV1 and Pain
Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis
... of pain reported by chronic pancreatitis patients ...if TRPV1 polymorphisms are associated with chronic pancreatitis, but we were actually interested in the question whether "TRPV1 polymor- phisms ...
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Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain
... OA pain 13 and can be activated by a wide range of endogenous bioactive ...endogenous TRPV1 ligand known to increase the fi ring of afferent fi bres via TRPV1 ...OA pain, providing a plausible ...
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No relevant modulation of TRPV1-mediated trigeminal pain by intranasal carbon dioxide in healthy humans
... whether TRPV1 receptor positive V1 neurons are indeed involved in migraine pathophysi- ology or not, they have been associated with other cra- niofacial pain syndromes such as dental pain where an ...
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Roles of Glia, Immune Cells and the Thermo-TRP Channels, TRPV1, TRPA1 and TRPM8, in Pathological Pain
... pathological pain has emerged during the last 2 ...channels TRPV1, TRPA1 and TRPM8 in the induction of pathological ...sensor TRPV1 has an overt role in noxious heat hyperalgesia or allodynia, ...
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Electroacupuncture Attenuates Visceral Pain and Reverses Upregulation of TRPV1 Expression in Adult Rats with Neonatal Maternal Deprivation
... visceral pain is a frequently used animal model for study mechanisms of visceral ...that TRPV1 expression was greatly upregulated in colon DRGs and that EA treatment reversed the up regulation of ...
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Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation
... of TRPV1 in regenerated neurons after inferior alveolar nerve (IAN) transection in ...on pain threshold at different time points after IAN transection by analyzing the escape thresholds to mechanical ...
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Peripheral mechanisms of inflammatory pain with particular reference to TRPV1, burn injury and the actions of certain gaseous general anaesthetics
... chronic pain states through activation of 5-HT7 and 5-HT3 receptors, respectively (Dogrul et ...that TRPV1, TRPA1, TRPV4, and ASIC ion channels are of special relevance in the context of ...
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Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons
... The TRPV1 transcript was present in prostate cancer-affected foci, both in the tumor tissue as well as in the adjacent untransformed part of the gland, traced by the cellular resolution of LCM ...a TRPV1 ...
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Original Article The mechanism of quercetin in regulating osteoclast activation and the PAR2/TRPV1 signaling pathway in the treatment of bone cancer pain
... inflammatory pain, neuropathic pain, and bone cancer ...activate TRPV1 and lead to Ca2+ influx, which induces DRG neurons via a calcium-dependent protein kinase II-cAMP reaction element binding pro- ...
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Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain
... sub-epidermal TRPV1-, TRPV4 or neurofilament – positive fibres were counted and the length and thickness of the epidermis was measured using a calibrated micro- scope, eyepiece ...
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Possible Implications of Endogenous Cannabinoid Receptors and Transient Receptor Potential Vannaloid-1 (trpv1) Receptors in Alcoholic Neuropathic Induced Pain in Wishtar Rat.
... neuropathic pain. Trpv1 is a ligand gated channel which gets activated in chronic ...of TRPV1 receptor in neuropathic pain during chronic alcoholism in wistar ...a TRPV1 receptor ...
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Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents
... the TRPV1-active sample was diverted into a mass spectrometer for electrospray (negative ion) ...assess TRPV1 biological activity using calcium imaging of CHO cells transfected with ...
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Pain control through selective chemo axotomy of centrally projecting TRPV1+ sensory neurons
... In our ongoing human clinical trial of RTX for intractable cancer pain, we were able to obtain DRG and spinal cord at autopsy from 1 male patient. The participant was monitored using cardiac electrodes throughout ...
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Secreted herpes simplex virus-2 glycoprotein G alters thermal pain sensitivity by modifying NGF effects on TRPV1
... SgG2 alters TrkA spatial distribution after injection Sensory neurons have very long projections. Signals acti- vated in a distal organ, like the skin, must reach the neur- onal cell body for their processing. When NGF ...
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Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression
... overexpressed TRPV1 with capsaicin in a lung cancer cell line both cause apoptosis [26, ...inducible TRPV1 over-expression. TRPV1 is a calcium permeable ion channel expressed in sensory neurons [29], ...
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Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: mechanosensitive TRPV1 as an “acupuncture responding channel”
... The TRPV1 agonist capsaicin (0.5%; Sigma-Aldrich, St. Louis, MO, USA) was dissolved in 5% ethanol, 5% Tween-20, and 90% saline. The concentration of capsa- icin was selected based on the report by Gear et al. : a ...
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Expression and functionality of TRPV1 in breast cancer cells
... is TRPV1. 10 TRPV1 agonist, capsaicin, is capable of inducing apoptosis 11,12 and inhibiting cancer cell growth by cell cycle arrest in many different types of cancer, for example, osteosarcoma, colon, and ...
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Quinoline as TRPV1 Antagonists: A New Approach against Inflammation
... The TRPV1 receptor, first cloned and characterized in 1997, is a non- selective cation channel expressed in primary sensory neurons, and is a key pain sensor and ...
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Ethanol Potentiates The TRPV1-Mediated Cough In The Guinea Pig
... burning pain sensation, that has proposed to be due to the sensitizing effect of ethanol on TRPV1 ...by TRPV1 activation in experimental animals and man is cough [14], and alcoholic drinks are ...
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Transient receptor potential Vanilloid 1 (TRPV1) in haematological malignancies
... Lymph node material is collected using a fine needle biopsy. A fine needle biopsy uses a thin, hollow needle to obtain fluid and tissue samples. This is performed under local anaesthesia. This procedure takes between ...
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