Trypanosoma brucei gambiense
Detection of Group 1 Trypanosoma brucei gambiense by Loop Mediated Isothermal Amplification
... Trypanosoma brucei gambiense is the causative agent of the Gambian form of human African trypanosomiasis (HAT) in sub-Saharan Africa and is responsible for over 90% of all HAT cases ...b. ...
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Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria
... by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th ...T. brucei is frequently reported as the causative ...b. gambiense) and ...
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INVESTIGATION OF LIVESTOCK FOR PRESENCE OF TRYPANOSOMA BRUCEI GAMBIENSE IN TAFA LOCAL GOVERNMENT AREA OF NIGER STATE, NIGERIA
... of Trypanosoma brucei gambiense in livestock to ascertain their reservoir role and also screened for other pathogenic trypanosomes of animals in Tafa Local Government Area of Niger state, ...with ...
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Luminescent multiplex viability assay for Trypanosoma brucei gambiense
... T.b. gambiense strain are not different from the wild type ...T.b. gambiense sleeping sickness to investigate whether the pHD 309 RLuc integration would have altered the drug sensitivity profile compared to ...
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The elimination of Trypanosoma brucei gambiense? Challenges of reservoir hosts and transmission cycles: Expect the unexpected
... b. gambiense transmission also comes from the rainforest area of South- ern Cameroon (HAT focus of ...b. gambiense were identi fi ed in 8% (n = 164) of wild animals (24 species) examined by PCR using ...b. ...
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Blood brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
... of Trypanosoma brucei gambiense cross human brain micro- vascular endothelial cells (BMECs), a human blood-brain barrier (BBB) model system, at much greater effi- ciency than do ...b. brucei. ...
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Anti-trypanosomal evaluation of Ximenia americana root bark and chromatographic-mass spectrometric profile
... Le et al. [17]. The flavonol has been established to have high radical scavenging capacity, thus anti-trypanosomal activity of X. americana root bark may be attributed possibly to antioxidant activity. Moreover, Maria et ...
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A comparative evaluation of PCR based methods for species specific determination of African animal trypanosomes in Ugandan cattle
... (Trypanosoma brucei bru- cei, Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense, Trypanosoma evansi and Trypanosoma equi- perdum), the most common ...
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Domestic pigs as potential reservoirs of human and animal trypanosomiasis in Northern Tanzania
... of Trypanosoma brucei s. l.; Trypanosoma brucei gambiense, the causative agent of chronic HAT, and ...b. gambiense) led by the World Health Organization (WHO), in- volving many ...
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Evaluation of the TbgI2 and TbgI17 Tandem Repeat Antigens as Potential Antigens for the Diagnosis of Trypanosoma brucei rhodesiense
... genus Trypanosoma which is transmitted to hu- mans through the bite of a tsetse fly [1] ...by Trypanosoma brucei gambiense ( Tbg ), pre- dominantly found in the Central and West Africa and the ...
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Sugar Nucleotide Pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major
... The non-protein-linked GPI structures include the so-called glycoinositolphospholipids, or GIPLs, that are most abundant in the leishmania and T. cruzi species (58, 64, 90) but are also found in procyclic-form T. ...
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Blood Profil of Dogs Experimentally Infected with Single Trypanosoma brucei, Ancylostoma caninum and Conjunct Trypanosoma brucei and Ancylostoma caninum and Treatment with Diminazene Aceturate and Mebendazole
... Repeated treatment with diminazene and mebendazole resulted in total clearance of both parasitaemia and faecal Ancylostoma eggs from the dogs. Subsequent improvement in both the PCV and Hb could be attributed to efficacy ...
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Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling
... Another possible mechanism of action of salinomycin could be that the ionophore increases the intracellular cat- ion level followed by a quick entry of water which would lead to cell swelling and damage of intracellular ...
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The detection and treatment of human African trypanosomiasis
... Abstract: Human African trypanosomiasis (HAT) is caused by the injection of Trypanosoma brucei (T. b.) gambiense or T. b. rhodesiense by Glossina, the tsetse fly. Three historical eras followed the ...
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Multiple Triclosan Targets in Trypanosoma brucei
... T. brucei genome database ...T. brucei to thiolactomycin, a known type II inhibitor that targets the -ketoacyl-acyl carrier protein (-ketoacyl-ACP) synthase ...T. brucei FAS is unknown, but some of ...
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Molecular epidemiology of African sleeping sickness
... Keywords: African trypanosomiasis; Trypanosoma brucei; sleeping sickness; molecular.. epidemiology; epidemics; microsatellites; genetics; population structure..[r] ...
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Rab23 is a flagellar protein in Trypanosoma brucei
... Genomes were chosen for sampling based on three main criteria: i) proposed position in the evolutionary tree of eukaryotes [21] ensuring adequate representation of major supergroups, ii) completeness of the sequenced ...
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An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics
... In conjunction with our commercial partner, MGB Biopharma, we have had great success in developing our MGBs as antibacterials [18] and, crucially, structural features of these MGBs are quite distinct from the diamidines. ...
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Mitochondrial DNA Ligases of Trypanosoma brucei
... Trypanosoma brucei is a parasitic protozoan and the etiologic agent of severe diseases of humans and livestock in sub- Saharan Africa ...T. brucei has also proved to be a valuable model system for ...
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The Trypanosomal Transferrin Receptor of Trypanosoma Brucei—A Review
... Received: 9 September 2019; Accepted: 25 September 2019; Published: 1 October 2019 Abstract: Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with ...
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